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16 Cards in this Set
- Front
- Back
First Generation Antipsychotics (typical):
MOA? Major SE? |
MOA: block central DA rec
SE: EPS (Parkinsonian syndrome, acute dystonias, akathisia), Tardive Dyskinesias, Sedation, NMS, Anticholinergic Sx, CV effects(alpha-adrenergic blockade, cardiac rhythm disturbances), Endocrine effects( decreased DA leads to increased prolactin), Weight Gain |
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Second Generation Antipsychotics (atypical):
MOA? Major SE? |
MOA: serotonin-dopamine antagonist
SE: less likely to produce EPS, tardive dyskinesia, and NMS, but many have SE of their own that limit their use **new concern that atypicals can increase risk of DMII (esp olanzapine and clozapine |
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chlorpromazine:
Class? t 1/2? Potency? |
First Generation Antipsychotic: (Thorazine)
t 1/2: 24hrs Potency: Low **Sedation and orthostatic hypotension are very common |
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haloperidol:
Class? t 1/2? Potency? |
First Generation Antipsychotic: (Haldol)
t 1/2: 24hrs Potency: High **EPS very common; available in IM Depot |
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thoridazine:
Class? t 1/2? Potency? |
First Generation Antipsychotic:
t 1/2: 24hrs Potency: Low **Higher incidence of cardiac disturbances,retinitis pigmentosa |
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mesoridazone:
Class? t 1/2? Potency? |
First Generation Antipsychotic:
t 1/2: 30hrs Potency: Low **Cardiac arrhythmias (torsades de pointes) |
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fluphenazine:
Class? t 1/2? Potency? |
First Generation Antipsychotic:
t 1/2: 18hrs Potency: High **Available in a long-acting intramuscular depot |
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molindone and loxapine are medium potency __________
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First Generation Antipsychotics
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trifluoperazine, thiothixene, perphenazine, and pimozide are high potency ___________
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First Generation Antipsychotics
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clozapine :
class? t 1/2? SE? |
Atypical Antipsychotic:
t 1/2: 5-15hrs SE: AGRANULOCYTOSIS, anticholinergic Sx, weight gain, sedation, NMS **CBC req weekly for 1st 6 mo and biweekly thereafter |
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risperidone:
class? t 1/2? SE? |
Atypical Antipsychotic: (Risperdal)
t1/2: 3 in fast metabloizers, 120 in poor metabolizers SE: Extrapyrimidal W/D syndrome in higher doses, postural hypotension, increased prolactin, weight gain, sedation, decreased concentration **present in breast milk |
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olanzapine:
class? t 1/2? SE? |
Atypical Antipsychotic: (Zyprexa)
t 1/2: 31hrs SE: increased prolactin, orthostatic hypotension, anticholinergic SE, weight gain, somnolence **alanine transferase levels as drug affects the liver |
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quetiapine:
class? t 1/2? SE? |
Atypical Antipsychotic: (Seroquel)
t 1/2: 7hrs SE: orthostatic hypotension, somnolence, transient increase in weight **slit lamp exam at baseline and every 6mo for those at risk of developing cataracts |
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ziprasidone:
class? t 1/2? SE? |
Atypical Antipsychotic: (Geodon, Zeldox)
t 1/2: 7hrs SE: dose-related QT interval prolongation, postural hypotension, sedation **present in breast milk, baseline K+ and Mg measurements |
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ariprazole:
class? t 1/2? SE? |
Atypical Antipsychotic: (Abilify)
t 1/2: 75hrs SE: HA, nausea, anxiety,insomnia, somnolence **nonsedating, no increased risk of weight gain or diabetes |
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In what way is aripiprazole different from other atypical antipsychotics?
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it is a partial agonist at DA and serotonin-1A receptors and antagonistic at postsynaptic serotonin-2A receptors allowing for less side effects
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