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56 Cards in this Set

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Trail Making Test (TMT)

two parts:


1. ss connects numbers from 1-25 scattered on paper


2. involves task switching. there are 13 numbers, 13 letters. connect number and letter in alternation. ie. 1-a-2-b-3-c-...




used as a general measure of attention. can only tell if there is a deficit present but not what deficit it.

Paced Auditory Serial Addition Test (PASAT)

ss hear series of numbers and must add the two most recently presented ones together


ex. 4 7 = 11


4 7 3 = 10


4 7 3 9 = 12


used as a general measure of attention. can only tell if there is a deficit present but not what deficit it.

Test of Attentional Performance (TAP)

battery with a wide range of subtests intended to capture different and independent attentional processes. able to test for specific deficit.


subtests:


1.alertness


2.divided attn


3.express saccade (disengagement)


4.overt/ covert shifting of attn.


5.visual search


6.go-no-go (response suppression)


7.incompatibility (resistance to interference)


8.crossmodal integration


9.neglect


10. attentional flexibility







Tests of Everyday Attention (TEA)

Listen to lecture 3:06

Traumatic Brain Injury (TBI)

Any kind of trauma to the head, can range from mild to severe.


Common cause of attn deficits.


Suggested that mental slowing caused by these due to a reduction in availability of attn resources



concussion

Caused by brain rocking back + forth in skull




85% of head injuries are concussions




Problems include slowness, difficulty in concentrating, difficulty in doing two things at once, and increased distractibility



Examples of brain diseases causing attention deficits

Alzheimer's, Parkinson's, Huntington's, Pick's and Schizophrenia

How are frontal lobe and parietal lobe deficits different?

Frontal: tend to be more related to executive function. ex. mental flexibility, inhibition and concentration


Parietal: tend to be more related to spatial attention.

Common causes of concussions

Contrecoup Injury

both sides of brain, front + back, hit skull

Why don't woodpeckers get concussions?

1. cranium is smooth, no friction.


2. straight on head collision better than angle impact (angle puts strain on corpus collosum)

Why don't helmets prevent concussions?

Can prevent fractures of skull but can't prevent brain from moving in head.

How do we diagnose concussions?

Glasgow Coma scale is one way used. although its not a very good indicator.

Glasgow Coma scale is one way used. although its not a very good indicator.

Early signs of a concussion

Why don't people realize they have a concussion?

at the time of impact people feel fine because brain is traumatized (in shock)

Why is it important to rest after a suspected concussion?

A second impact right after the first can be fatal (second impact syndrome). Brain is very vulnerable and needs time to heal.

What happens in the brain when a concussions occurs?

When hit, leads to ion channelopathy.


Ion channels stop working and acetylcholine (toxic) cannot get taken back inside the cell, leading to damage to neighbouring cells.

Ion channels

Why does it seem like women are more suscpetible to concussions?

1. men lie?! under report concussions


2. different neck and trap. muscles (larger in men)?


3. genetic difference in brain shaking tolerability?

Why are brain scans a bad indicator of concussions?

scans won't show anything unless bleeding.


bad b/c Dr. might disregard because nothing looks abnormal

Why is DTI a good technique to diagnose concussions?

injury due to axons, way to small to show on MRI or CT.


DTI can show white matter (axon) differences

Effects of TBI on attention

1. poor concentration and lack of mental energy


2. increased interference by distractors


3. slower detection of targets during search


4. divided attn capacity impaired


5. increased stroop interference


6. higher frequency of action slips


7. reduced activation of executive attn areas


8. mental slowing (extreme fatigue)

Chronic traumatic encephalopathy (CTE)

"punch drunk"


Progressive degenerative disease found in people who have had a severe blow or repeated blows to the head.


Characterized by larger ventricles, degradation, similar to Alzheimer's

How is Alzheimer's like a type 3 diabetes?

according to study, if you cut off insulin to brain you see same effect as Alzheimer's

Brain diseases associated with frontal cortical impairment

Parkinson's: reduces activation in basal ganglia


Huntington's: effects frontal cortical areas


Schizophrenia: decreases frontal cortical activation


Depression

Attention Deficit Disorder (ADD)

Neurological disorder characterized by increased distractibility and inability to focus attn in consistent manner.

How to treat ADD?

Treated with stimulants (ex. adderall and ritalin)


Increases level of dopamine and NE in prefrontal cortex

What causes ADD?

suspected that it's caused by:


1. dysfunction of the thalamus because of its role in filtering


2.diminished function of the right hem.


3. deficit in the availability of attn resources


4. under-production of under-utilization of NT's



Brain activation during concussion recovery

How are spatial deficits brought about? (most commonly)

by stokes and effects the parietal cortex

Hemianopia

vision compromised, only 1 side of visual field



Blindsight

Sometimes can't see things in part of visual field


accurate at guessing when given options


Caused by problem with primary visual pathway (cones), but rods still work



Primary visual pathway

from cone cells


more direct root to brain (visual cortex)

Secondary visual pathway

from rod cells


a more primitive pathway leading to the brainstem


involved in reflexive behaviour


unaware of this secondary pathway

Graham Young

Blindsight patient


Able to detect motion and orientation but can not physically see characteristics


if he turns his head to see, he is aware


is aware of his disorder

Spatial Neglect

attentional deficit usually caused by stroke. Characterized by lack of awareness of objects in left visual hemifield.


May also be unaware of left half of objects, and can still perceive sensations.

How is blindsight different from neglect?

Blindsight patients are aware of their deficit and therefore can move head to compensate. Neglect patients are not aware of their problem.

Ischemic stroke

caused by blockage - plaque built up in arteries of brain, problems with clots.



Hemmorrhagic stroke

burst aneurysm - weak section of arterial wall burts



Signs of stroke



Somatoparaphrenia

unaware of own body

Visual Extinction

occurs with parieto-occiptical lesions


if two objects presented simultaneously, they do not "see" the object presented contralateral to lesion.


can identify object, if nothing is in other field.



Diagnosing Neglect (Tests)

Line bisection test


Line cancellation test


Line drawing test

Line bisection test

where is the middle?

where is the middle?

Line cancellation test

bisect white lines

bisect white lines

Line drawing test

copy line drawing

copy line drawing

Posner Task - Extinction Findings

1.when cue + target in right (good) side, can respond.


2.when cue + target in left (bad) side, slower response.


3.when cue is on right, target left, takes longest to respond



Can people recover from neglect?

yes!


ex. patient who drew self portrait started drawing more accurately as he recovered

How do we know that patients with neglect are processing stimuli unconsciously?

tests show stimuli in bad field can prime understanding of stimuli in good field

True or False: neglect extends to mental images as well.

True.


ex. Peggy Palmer would only draw half a daisy from memory

Why does neglect occur?

1. right hem. is attention center. ie. L parietal lesion does not lead to neglect


2. dynamic hem. imbalance - R hem damage results in dominant L hem and right side bias



Plaza study

method:


ss asked to describe an image of a famous plaza in italy from a specific position (ie. facing south)




findings:


would only report half of the plaza, but when "turned around" would report the other half



What does this study suggest? and why?

What does this study suggest? and why?

spatial neglect can be object-based.


When the object gets flipped, subjects reported correctly where dot was when presented in the initially good visual field, but slower to respond when initially presented in the bad field.

What happens if we lessen L hem dominance in patients with neglect?

caloric stimulation (ice cold water in left ear) = recovery of neglect temporarily by shocking the left hemisphere


TMS can also reduce neglect (lasts longer)



Simultagnosia

symptom of Balint's syndrome characterized by the inability to perceive different pieces of information in the visual field simultaneously because the person cannot direct attn to more than 1 small location at a time.


Disappears if objects are connected



Balint's Syndrome

attnetion deficit characterized by a collection of related symptoms that include optic ataxia, ocular apraxia, and simultagnosia.


Caused by bilateral dorsal parietal lesions.

Attentional Dyslexia

cause by left parietal damage.


could read well but impaired ability to report single letters.


errors due to mislocations (like illusory conjunctions)