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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Name 2 LHRH agonists
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Leuprolide & Goserelin
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Name on GnRH antagonist
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Degarelix
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Leuprolide
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LHRH agonist
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Goserelin
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LHRH agonist
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Degarelix
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GnRH antagonist
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Name some of the common SEs with LHRH agonists
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Impotence
Gynecomastia Hot flashes Decreases libido Coronary Heart Disease |
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Name some of the serious SEs of LHRH agonists?
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MI & sudden cardiac death
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Explain the "Tumor Flare Reaction" and which class of drugs it is seen with.
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Once the LHRH receptor is blocked, it causes an initial increase in the induction of LH & FSH. This can actually flare the tumor up, causing transient increased bone pain, & urinary sxs.
LHRH agonists. **What do you do tho prevent this? |
Give anti-androgens starting one week prior to the starting dose of Leuprolide or Goserelin, then for one month
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Leurolide & Goserelin: Name route of administration
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Leurolide= Two different brand names based on ROA:
SQ= Eligard IM= Lupron (Q 3-6 months) Zoldaex= implant injected into upper abdomen (monthly or Q 3 mos) |
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Name 3 anti-androgens
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Rem! BiNiFlu
Flutamide Nilutamide Bicalutamide |
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Name some adverse reactions of the anti-androgens
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Diarrhea (2-26%)
Hematuria Hot flashes Peripheral edema Nilutamide only= disulfiram-like reaction, decrease visual accomodation, interstial nephritis |
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Explain the place in therapy for hormonal therapy
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progression after medical or surgical castration & anti-androgens
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Second line hormone therapy for prostate cancer includes what class of drugs? Explain the MOA
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corticosteroids (prednisone or dexamethasone) & megestol acetate (Megace)
MOA: suppresses ACTH, which decreases the amount of adrenal androgens made (CS) Megace: inhibits LH release, blocks androgen receptor, & inhibits 5alpha-reductase activity |
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What are some side effects of Megace?
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fluid retention
appetite stimulation insomnia hyperglycemia osteoporsis weight gain |
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