Pros And Cons Of Antibiotic Classes

Front 1

What are the pros/indications of aminoglycosides?

Back 1

Excellent gram-negative activity (inc. P. aeruginosa)

Rapidly bactericidal

Synergistic activity with penicillin

Front 2

What are the cons of aminoglycosides?

Back 2

Poor lipid solubility (low CNS penetration)

Activity pH dependent

No oral formulation

Front 3

What are the pros/indications of glycopeptides?

Back 3

Excellent gram-positive activity (inc. MRSA and coag -ve staph)

Used for line infections, CAPD peritonitis, CNS shunt infections

PO formulation used to treat C. difficile diarrhoea/colitis

Front 4

Cons of glycopeptides?

Back 4

Oral formulation is not absorbed so cannot be used for systemic infections

Front 5

Pros/indications of quinolones?

Back 5

Oral and IV formulations, v. good bioavailability

Good tissue penetration

Excellent gram neg activity (inc P aeruginosa)

Front 6

Cons of quinolones?

Back 6

Drug interactions; theophylline, amiodarone

Front 7

Pros/indications of tetracyclines?

Back 7

Excellent activity against intracellular organisms

Covers atypicals

Front 8

Cons of tetracyclines

Back 8

Most only have oral formulations

Front 9

Pros/indications of lincosamides?

Back 9

Anti-toxin

Excellent oral bioavailability

Good tissue penetration

Anaerobic activity

Front 10

Pros/indications of sulphonamids/Co-trimoxazole?

Back 10

Broad antimicrobial spectrum

Sulphonamides have good CSF penetration (oral and IV)

Front 11

Cons of co-trimoxazole?

Back 11

generally reserved for treatment/prevention of PCP and toxoplasmosis due to serious ADR

Front 12

Pros of chloramphenicol

Back 12

Broad spectrum

Resistance is uncommon

Excellent CSF penetration

Front 13

Cons of chloramphenicol

Back 13

Bacteriostatic (cidal to H. influenzae)