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34 Cards in this Set

  • Front
  • Back

Formation of intravascular clot

Thrombosis

Agents that promote coagulation

Procoagulant

Process of dissolving formed clot of fibrinogen

Fibrinolysis

<3mm skin hemorrhage

Petechiae

1cm skin hemorrhage

Purpura

>3mm skin hemorrhage

Eccymosis

Chronic dilation of capillary walls

Telangiectasia

Excessive menstrual bleeding

Menorrhagia

Irregular uterine bleeding not related to menstruatiom

Metrorrhagia

Sweating of blood: can be cause by severe anxiety

Hematohidrosis

Nosebleed

Epistaxis

Vomiting of blood

Hematemesis

Expectoration of blood

Hemoptysis

Leakage of blood into joint cavity

Hemathrosis

Passage of fresh blood in stools

Hematochezia

Passage of red blood in stools (black/tarry)

Melena

Involves the tissue surrounding a vessel, which become involve in hemostasis when a blood vessel is injured

Extravascular component

Involves the vessel through which blood flows; depends on their size, the amount of smooth muscle within their walls, and integrity of endothelial cell lining

Vascular component

The platelets and plasma proteins that circulate within blood vessels; involve in coagulation or fibrinolysis

Intravascular component

First coagulation disorder to be reconized

Hemophilia

Refers to the role of blood vessels and platelet in the initial formation of a platelet plug in response to a vascular injury

Primary hemostasis

Activation of a series of plasma proteins in the coagulation system to form a fibrin clot. Involves the coagulation factors

Secondary hemostasis

Monolayer of metabolically active cells found in the innermost lining of blood vessel

Endothelial cells

Exterior coat and contains glycoprotein receptor sites

Glycocalyx

Contains phospholipid membrane, which serves as a surface for interaction of coagulation factors in secondary hemostasis

Submembrane area

Contains microtubules, cytoskeleton, actin and myosin

Sol-gel zone

Contains the granules, lysosomes, mitochondria, peroxisomes and glycogen

Organelle zone

Regulator of intracellular calcium concentration

Dense tubular system

Releases granular contents through channels leading to the surface of the platelet

Open cannicular system

Depending on binding of von willebrand factor and GpIb/IX receptor site

Platelet adhesion

Response to collagen exposure in subendothelium cause by vascular injury

Platelet adhesion

Platelet undergo shape change and the alpha and dense granules release substances that contribute to platelet aggregation and activation of the coagulation

Platelet release reaction

Requires GpIIb/IIIa and fibrinogen

Platelet aggregation

Fibrinogen attaches at the gpIIb/IIIa receptor at adjoining platelets, forming the initial platelet plug

Platelet aggregation