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34 Cards in this Set
- Front
- Back
Formation of intravascular clot |
Thrombosis |
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Agents that promote coagulation |
Procoagulant |
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Process of dissolving formed clot of fibrinogen |
Fibrinolysis |
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<3mm skin hemorrhage |
Petechiae |
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1cm skin hemorrhage |
Purpura |
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>3mm skin hemorrhage |
Eccymosis |
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Chronic dilation of capillary walls |
Telangiectasia |
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Excessive menstrual bleeding |
Menorrhagia |
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Irregular uterine bleeding not related to menstruatiom |
Metrorrhagia |
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Sweating of blood: can be cause by severe anxiety |
Hematohidrosis |
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Nosebleed |
Epistaxis |
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Vomiting of blood |
Hematemesis |
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Expectoration of blood |
Hemoptysis |
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Leakage of blood into joint cavity |
Hemathrosis |
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Passage of fresh blood in stools |
Hematochezia |
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Passage of red blood in stools (black/tarry) |
Melena |
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Involves the tissue surrounding a vessel, which become involve in hemostasis when a blood vessel is injured |
Extravascular component |
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Involves the vessel through which blood flows; depends on their size, the amount of smooth muscle within their walls, and integrity of endothelial cell lining |
Vascular component |
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The platelets and plasma proteins that circulate within blood vessels; involve in coagulation or fibrinolysis |
Intravascular component |
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First coagulation disorder to be reconized |
Hemophilia |
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Refers to the role of blood vessels and platelet in the initial formation of a platelet plug in response to a vascular injury |
Primary hemostasis |
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Activation of a series of plasma proteins in the coagulation system to form a fibrin clot. Involves the coagulation factors |
Secondary hemostasis |
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Monolayer of metabolically active cells found in the innermost lining of blood vessel |
Endothelial cells |
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Exterior coat and contains glycoprotein receptor sites |
Glycocalyx |
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Contains phospholipid membrane, which serves as a surface for interaction of coagulation factors in secondary hemostasis |
Submembrane area |
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Contains microtubules, cytoskeleton, actin and myosin |
Sol-gel zone |
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Contains the granules, lysosomes, mitochondria, peroxisomes and glycogen |
Organelle zone |
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Regulator of intracellular calcium concentration |
Dense tubular system |
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Releases granular contents through channels leading to the surface of the platelet |
Open cannicular system |
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Depending on binding of von willebrand factor and GpIb/IX receptor site |
Platelet adhesion |
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Response to collagen exposure in subendothelium cause by vascular injury |
Platelet adhesion |
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Platelet undergo shape change and the alpha and dense granules release substances that contribute to platelet aggregation and activation of the coagulation |
Platelet release reaction |
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Requires GpIIb/IIIa and fibrinogen |
Platelet aggregation |
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Fibrinogen attaches at the gpIIb/IIIa receptor at adjoining platelets, forming the initial platelet plug |
Platelet aggregation |