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10 Cards in this Set
- Front
- Back
What aggravates porphyria?
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Pregnancy
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What provokes porphyria?
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BaKED BuMPS: Barbiturates, Ketamine, Ethanol, Dilantin, Benzos, Meprobamate, Pentazocine, Sepsis (+dehydration and hypoglycemia)
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What is a safe anesthetic for known porphyria?
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Inhalation agents, narcotics, droperidol, chloropromazine, anticholinergics, anticholinesterases, depolarizing/nondepolarizing muscle relaxants.
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What causes atypical pseduocholinesterase?
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inheritated change of gene responsible for liver enzyme production
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What is the effect of atypical pseudocholinesterase?
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Slowed hydrolysis of Sux, miva, ester-type LA
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How is atypical pseduocholinesterase dx'd?
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Abnormal dibucaine/fluride #
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What #s are associated w/ a prolonged response to sux?
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Dibucaine: 50-60 (nml 78-86); Fluride: 25-35 (nml 55-65)
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What drugs decrease serum cholinesterase?
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B-blockers, steroids, P450 induction
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What pathological states decrease serum cholinesterase?
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TaBeL UP MOM: TB, burns, liver dys, malignancy, uremia, organophosphates, malnutrition, pregnancy
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What are the four major pathologies to check for in an interview?
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MH, Adrenal suppression, Porphyria, Atypical pseduocholinesterase
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