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11 Cards in this Set
- Front
- Back
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five main classes of tissue how do cells adhere to each other? how to cells adhere to matrix? |
epithelial, connective, muscular, neuronal, blood cell-cell junction occurs by cell-adhesion molecules (CAMs) to form specialized junctions cell-matrix junction occurs by adhesion receptors |
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adhesion of cells in the intestinal epithelium: what are the three animal-cell junctions in simple columnar epithelia? what are their functions? |
anchoring junction, tight junction, and gap junction anchoring + tight junction hold tissue together Tight junction controls solute flow Gap junction let's small molecules though |
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types of anchoring junctions? (3) |
adherens junction: connect adjacent epithelial cells with actin and myosin to act as tension cable desmosomes: "plaque"; uses IF to hold its structure, integrins inside and attach firmly hemidesmosomes: usually at basal surface, focal contacts (focal adhesions) anchor epithelium to components of underlying ECM |
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what are tight junctions? what proteins make up tight junctions? |
hold tissue together control solute flow - prevent diffusion of macromolecules, and sometimes small water-soluble molecules and ions composed of thin plasma-membrane proteins - occuludin, tricellulin, jam |
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what are gap junctions? what are vertebrate gap junctions composed of? |
help rapid diffusion of small, water-soluble molecules between cytoplasm and adjacent cells; does not play a key role in strengthening cell-cell or cell-matrix adhesions vertebrate gap junctions are composed of connexon (2 connexins) (transmembrane proteins) |
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what types of junctions are there? (3) adhesion type? principal cams or adhesion receptor? cytoskeletal attachment? function? |
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the four families of cell adhesion molecules (CAMs) types of interactions |
cadherins: can be calcium dependent immunoglobulin superfamily: CAMs, homo + heterophilic linkages integrins: heterodimeric, ex. fibronectin selectins: have CHO binding lectin domain adhesions can be homotypic (same cells) or heterotypic (diff types of cells) CAM can bind to same CAM homophilic or diff class heterophilic binding |
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properties of cadherin homotypic or heterotypic? three major cadherin classes? what does e-cad form? structure of cadherin? |
homotypic and requires calcium for adhesion can have cis (all in same cell) or trans (diff cells) interactions three major classes: E, N, P e-cad forms adherens junctions and desmosomes structure: transmembrane domain, short C-terminal cytosolic domain, and 5 cadherin domains (E1-E5) for calcium binding and cad-med cell-cell adhesion E1 and E2 domains for interactions |
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what do desmosomes contain? |
desmosomes contain two specialized cadherins; cytosolic domains are distinct from classical cadherins, bind to adaptor proteins to make plaque mediate plaque binding to IF |
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what is the ECM made of? two types of ECM? major components? function? |
secreted proteins, polysaccharides basal lamina, connective tissue proteoglycans, collagen fibers, multi-adhesive matrix proteins, elastin physical support for cells, intracellular signaling |
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what four ubiquitous protein components are in the ECM? |
type IV collagen: form 2d network, can bind to adhesion receptors, including integrins, triple helix laminins: main protein, form 2d network with collagen, bind to integrins and other adhesion receptors perlecan: proteoglycan binds to and cross-links ECM components and cell-surface molecules nidogen: cross links collagen, perlecan, laminin |
