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13 Cards in this Set
- Front
- Back
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Gaisbock polycythemia |
Polycythemia due to stress |
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What cell lineages are proliferated? |
Erythroid Myeloids Megakaryocytes (platelets) Granulocytes |
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Types of polycythemia |
Absolute-- primary and secondary Relative |
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5 causes of absolute polycythemia |
Primary polycythemia Hypoxia Carboxyhaemoglobim Cushing syndrome or steroids Erythropoietin secreting tumours |
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Epidemiology of polycythemia |
Diagnosis is at age 60yrs Occurs in 3 of 100,000 Rare below age 30yrs |
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Complications due to thrombosis in PCV |
Cardiovascular accident Transient Ischaemic Attack Myocardial infarction Deep vein thrombosis |
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Physical findings in pcv |
Splenomegaly Hepatomegaly Face plethora |
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Symptoms due to hyperviscosity |
Dizziness Weakness Headache Priapism Paraesthesia |
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Diagnostic criteria of pcv - minor |
Hypercellular of BM Low EPO Endogenous erythroid colony growth (EEC) |
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Diagnostic criteria- Major |
In men: Hb >18.5 HCT> 0.52 In women: Hb> 16.5 HCT> 0.48 Presence of JAK2-V617F mutation |
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Rx of PCV |
Phlebotomy Hydroxyurea Alpha interferons Busulphan Radioactive phosphorus |
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Causes of secondary thrombocytosis |
Malignancies Infections Post surgical status Connective tissue disorders Iron deficiency anaemia BM recovery due to alcohol and smoking Splenectomy |
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Prognosis |
Without therapy survival rate is 6-18monthe With therapy it is > 10yrs Up to 20% of pts develop AML or MDS haemorrhage and thrombosis are the major cause of DEATH |
