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37 Cards in this Set
- Front
- Back
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What's the primary source of mucus?
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submucosal glands
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what type of cells are located on / in the surface of the epithelium?
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gobelt cells
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what cells protect the small airways?
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clara cells
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Indications for Mucoactive Agents
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decrease in Mucocilary Transport Rates from:
Parasympatholytics - M3 atropine Hypoxemia High FiO2: hyperoxia air pollution cigarette smoke narcotics dehyrdration - decreased humidity artificial airways - requires suction |
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Mucoactive Agents
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Affect Mucociliary Escalator
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Mucoactive Agents - Affect Mucociliary Escalator
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Hydration - Most important preventative agent
wetting agents - humidify & mobilize secretions Help loosen/thin secretions bland aerosols (H2O) - can cause bronchospams normal saline (0.9% - physiologic) Expectorants - cough medicine Hypertonic saline (> 0.9%) Bronchodilators are included in the category of mukokinetics |
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N-Acetylcysteine
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(NAC) - Mucomyst
Mucolytic - breaks disulfide bonds-reduced the accumulation of excessive airway secretions Usage: Refrigerate: label opening date/time, discard after 96 hours 3 to 5 mL 20% or 10% TID/QID Hazards / side effects Give with or just after B2 adrenergic bronchodilator ***** Bronchospasm hazard: NO ASTHMATICS Nursing: Oral antidote for acetaminophen (Tylenol) overdose |
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Dornase alfa
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Pulmozyme
approved for CF patients (only) patient mut be hydrated dissolves pus-related DNA in mucus decreases reoccurring infections decreases frequency of exacerbations usage: keep refrigerated, out of light separate specialized nebulizer dosage 2.5mg/UD SVN q-day must use its own SVN - accurage delivry $ drug NO MIXING with other drugs |
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What is the dose for Dornase Alfa?
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2.5mg
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Brand name for Dornase Alfa?
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Pulmozyme
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How is Dornase Alfa stored?
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refrigerated, out of light
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What is something you could use to mobilize secretions without mucolytics?
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wetting agents - bland aerosol - saline solution - 0.9% solution
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What are inspissated secretions?
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dehydrated / super thick / dry
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smells like sulfer
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acetylcysteine (mucomyst)
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Pulmozyme is indicated for
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CF patients - mucus is more purulent
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what diseases are typically associated with acetylcysteine?
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CB, emphysema
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what is the process of acetylcysteine
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breaks down disulfide bonds
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how are brochodilators categorized?
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mucokinetics
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what might cause mucokinetics to be hampered?
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cigarette smoke, hyperoxemia, M3, dehydration
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what makes mucus stick together?
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cohesiveness / adhesiveness
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describe adhesive in charting
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tenacious
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describe cohesive in charting
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thin / thick
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how long is acetylcysteine good for?
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4 days, 96 hours - must be given with a bronchodilator
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corticosteroid comes from
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the adrenal cortex
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Budesonide
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Pulmicort Flexhaler
Pulmicort Respules |
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Budesonide/formoterol
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Symbicort
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Ipratropium Bromide
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Atrovent
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Ipratropium bromide & albuterol
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Combivent - MDI
DuoNeb - SVN, DPI |
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Atrovent
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Ipratropium bromide
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Tiotropium bromide
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Spiriva
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What is the significant indication of Aformoterol?
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Approved for COPD only
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Brovana is for use by?
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Approved for COPD only
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Spiriva
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Triotropium Bromide
Long lasting inhaled Anticholinergic Bronchodilator DPI Duration 12 hours |
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What could you give for antidote for acetaminophen (Tylenol) overdose?
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N-Acetylcysteine (NAC) - Mucomyst
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If it smells like sulfer, it must be given with
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a bronchodilator.
Acetylcysteine / Mucomyst |
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What's unique about the delivery of Dornase alfa?
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specialized nebulizer
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Generic name for flovent?
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Fluticasone
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