Phm 350 Exam Ii

Front 1

A drug which induces general anesthesia but for which flumazenil (ROMAZICON) is NOT a pharmacological antagonist:
A. Midazolam (VERSED)
B. Buspirone (BUSPAR)
C. Thiopental (PENTOTHAL)
D. Haloperidol (HALDOL)
E. A and C above.

Back 1

C. Thiopental (PENTOTHAL)

Front 2

Benzodiazepines:
A. Decrease reuptake of GABA into axon terminals
B. Reduce the response of neurons to GABA
C. Increase the affinity of GABA for its binding site on the GABAA receptor
D. Prevent GABA from interacting with GABA receptors
E. A and C

Back 2

C. Increase the affinity of GABA for its binding site on the GABAA receptor

Front 3

A facilitator of GABA mediated transmission used clinically in treatment of panic disorder:
A. Flumazenil (ROMAZICON)
B. Midazolam (VERSED)
C. Buspirone (BUSPAR)
D. Alprozalam (XANAX)
E. Triazolam (HALCION)

Back 3

D. Alprozalam (XANAX)

Front 4

A drug which has anti-inflammatory effects and immunosuppressant effects by inhibiting
lipoxygenase:
A. Prednisone
B. Imipramine
C. Zileuton
D. Montelukast
E. A and C above.

Back 4

C. Zileuton

Front 5

Naltrexone (TREXAN) is:
A. Causes miosis in overdose
B. Is an opiate receptor agonist
C. Used to treat alcohol dependence
D. Is used to treat depression
E. A and C, above.

Back 5

C. Used to treat alcohol dependence

Front 6

E6. A drug that binds to and activates brain dopaminergic receptors and that is used in the treatment
of Parkinson's disease
A. Bromocriptine (PARLODEL)
B. Selegiline (ELDEPRYL)
C. Pramipexole (MIRAPEX)
D. Levodopa (DOPA)
E. A and C, above.

Back 6

E. A and C, above.

PARLODEL & MIRAPEX

Front 7

Follicle stimulating hormone:
A. Is used in oral contraceptive preparations
B. Is secreted by cells of the anterior pituitary gland
C. Induces ovulation
D. Is secreted by the hypothalamus
E. A and C.

Back 7

B. Is secreted by cells of the anterior pituitary gland

Front 8

Cortisone:
A. Acts as an immune system stimulant
B. Reduces lipolytic activity in adipose tissue
C. Prevents hyperglycemia
D. Induces loss of bone mass
E. A and C, above.

Back 8

D. Induces loss of bone mass

Front 9

Morphine causes:
A. Cough suppression
B. Mydriasis
C. Hyperalgesia (i.e., increased pain sensitivity)
D. Diarrhea
E. A and C.

Back 9

A. Cough suppression

Front 10

Methadone (DOLOPHINE):
A. Is an analgesic
B. Is used to treat acute morphine overdose
C. Is used as a morphine/heroin substitute in morphine/heroin addicts because methadone
seems to produce a less intense (i.e. less severe) withdrawal (on removal of the drug) than
does morphine/heroin.
D. Is used as a morphine substitute in morphine/heroin addicts because tolerance to
methadone does not develop (in the same way that tolerance to morphine develops)
E. A and C above.

Back 10

E. A and C above.
A. Is an analgesic

C. Is used as a morphine/heroin substitute in morphine/heroin addicts because methadone seems to produce a less intense (i.e. less severe) withdrawal (on removal of the drug) than does morphine/heroin.

Front 11

Which of the following is not a steroid hormone:
A. Estradiol
B. ACTH
C. Cortisol
D. Progesterone
E. A and C.

Back 11

B. ACTH

Front 12

Clomiphene:
A. Is used to treat reproductive infertility in men
B. Is used as an daily oral contraceptive pill
C. Is used to induce a “medicinal abortion”
D. Is used to treat certain types of reproductive infertility in women
E. Is an antagonist at progesterone receptors

Back 12

D. Is used to treat certain types of reproductive infertility in women

Front 13

Lithium:
A. Is rapidly biotransformed (metabolized) in the liver
B. Is used to treat unipolar depression
C. Is used to treat manic phases of bipolar disorder (aka manic depression)
D. Is an organic ion
E. None of the above.

Back 13

C. Is used to treat manic phases of bipolar disorder (aka manic depression)

Front 14

Which of the following is used clinically for its significant antidiarrheal action?
A. Fluoxetine
B. Loperamide
C. Naloxone
D. Haloperidol
E. None of the above.

Back 14

B. Loperamide

Front 15

Prednisone will:
A. Increase production/presence/activity of the phospholipase inhibitor lipocortin
B. Increase production of prostaglandins at sites of inflammation
C. Decrease production of prostaglandins at sites of inflammation
D. Increase permeability of capillary blood vessels at the site of inflammation
E. A and C.

Back 15

E. A and C.

A. Increase production/presence/activity of the phospholipase inhibitor lipocortin

C. Decrease production of prostaglandins at sites of inflammation

Front 16

A drug used to treat depression which is a selective serotonin reuptake inhibitor:
A. Isocarboxazid (MARPLAN)
B. Levodopa (DOPAR)
C. Imipramine (TOFRANIL)
D. Amantadine (SYMMETREL)
E. Sertraline (ZOLOFT)

Back 16

E. Sertraline (ZOLOFT)

Front 17

A drug that increases the synthesis of dopamine from brain dopaminergic neurons in the brain and
which is used in the treatment of Parkinson's disease:
A. Isocarboxazid (MARPLAN)
B. Levodopa (DOPAR)
C. Imipramine (TOFRANIL)
D. Amantadine (SYMMETREL)
E. Sertraline (ZOLOFT)

Back 17

B. Levodopa (DOPAR)

Front 18

Imipramine (TOFRANIL):
A. Inhibits the activity of monoamine oxidase
B. Has side effects mediated by nicotinic cholinergic receptors
C. Is a selective serotonin reuptake inhibitor (SSRI)
D. Inhibits the re-uptake of norepinephrine
E. A and C

Back 18

D. Inhibits the re-uptake of norepinephrine

Front 19

Morphine:
A. Reduces intracranial pressure and is therefore useful in treatment of head injuries
B. Increases the motility of the gastrointestinal tract
C. Blocks neurotransmission in central pain pathways
D. Acts as an analgesic by blocking the formation of prostaglandins at the site of a wound
E. A and C, above.

Back 19

C. Blocks neurotransmission in central pain pathways

Front 20

A drug which has anti-inflammatory effects and is effective in treatment of asthma because it is an
antagonist at leukotriene receptors
A. Zileuton
B. Montelukast
C. Imipramine
D. Prednisone
E. A and C above.

Back 20

B. Montelukast

Front 21

A facilitator of GABA mediated neurotransmission which is used clinically to treat insomnia:
A. Flumazenil (ROMAZICON)
B. Triazolam (HALCION)
C. Midazolam (VERSED)
D. Buspirone (BUSPAR)
E. Alprozalam (XANAX)

Back 21

B. Triazolam (HALCION)

Front 22

Acetaminophen (TYLENOL):
A. Like aspirin is a useful anti-pyretic drug because it inhibits central cyclooxygenases
B. Blocks pain pathways in the central nervous system
C. Is a weak antiinflammatory drug because it is bound/inhibited by peroxide compounds
formed at sites of inflammation
D. Alters cellular respiration and upsets blood acid-base balance
E. A and C

Back 22

E. A and C
A. Like aspirin is a useful anti-pyretic drug because it inhibits central cyclooxygenases
C. Is a weak antiinflammatory drug because it is bound/inhibited by peroxide compounds

Front 23

Naloxone (NARCAN) is used:
A. As an analgesic
B. As a treatment for insomnia
C. As an opiate receptor agonist
D. To reverse the effects of morphine overdose
E. A and C.

Back 23

D. To reverse the effects of morphine overdose

Front 24

A facilitator of GABA mediated neurotransmission which is used clinically as an anesthetic:
A. Flumazenil (ROMAZICON)
B. Fluoxetine (PROZAC)
C. Alprozalam (XANAX)
D. Midazolam (VERSED)
E. Triazolam (HALCION)

Back 24

D. Midazolam (VERSED)

Front 25

Phenelzine (NARDIL):
A. Is an effective antidepressant through its action as monoamine oxidase inhibitor
B. Is an antidepressant through its actions to inhibit the uptake of norepinephrine by
norepinephrine secreting axon terminals
C. Has potential side effects mediated through effects on sympathetic norepinephrine secreting
neurons
D. Is useful to treat schizophrenia
E. A and C.

Back 25

E. A and C.
A. Is an effective antidepressant through its action as monoamine oxidase inhibitor
C. Has potential side effects mediated through effects on sympathetic norepinephrine secreting
neurons

Front 26

Haloperidol (HALDOL) acts therapeutically as an antipsychotic by:
A. Inhibiting uptake of serotonin in the brain
B. Inhibiting uptake of norepinephrine in the brain
C. Blocking dopamine receptors in limbic and cortical areas of the brain
D. Blocking cholinergic muscarinic receptors
E. A and C above.

Back 26

C. Blocking dopamine receptors in limbic and cortical areas of the brain

Front 27

Fluoxetine:
A. Is marketed and prescribed as PROZAC for treatment of depression
B. Is a monoamine oxidase inhibitor
C. Is marketed and prescribed as SARAFEM for premenstrual dsyphoric disorder (aka “PMS”)
D. Is used in the treatment of insomnia
E. A and C, above.

Back 27

E. A and C, above.
A. Is marketed and prescribed as PROZAC for treatment of depression
C. Is marketed and prescribed as SARAFEM for premenstrual dsyphoric disorder (aka “PMS”)

Front 28

E28. Glucocorticoids:
A. Are used to suppress the immune system after organ transplant
B. Are used to prevent osteoporosis
C. Are used to treat multiple sclerosis
D. Increase leukocyte migration into tissue at sites of inflammation
E. A and C.

Back 28

E. A and C.
A. Are used to suppress the immune system after organ transplant
C. Are used to treat multiple sclerosis

Front 29

Indomethacin (INDOCIN) is used to treat:
A. Depression
B. Overdose with morphine
C. Parkinson’s disease
D. Patent ductus arteriosus
E. A and C.

Back 29

D. Patent ductus arteriosus

Front 30

Tamoxifen:
A. Is used to treat depression
B. Is an antagonist at estrogen receptors in the heart and is used in treatment of breast cancer
C. Is used to treat manic phases of bipolar disorder
D. Is an agonist at progesterone receptors and is used as an oral contraceptive
E. A and C above.

Back 30

B. Is an antagonist at estrogen receptors in the heart and is used in treatment of breast cancer formed at sites of inflammation

Front 31

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Estrogen-and-progestin containing oral contraceptives:
1. Decrease secretion of follicle stimulating hormone and luteinizing hormone from the pituitary
gland
2. Interfere with follicle maturation
3. Inhibit ovulation
4. Promote changes in the endometrium which favor implantation of the fertilized ovum.

Back 31

A
1. Decrease secretion of follicle stimulating hormone and luteinizing hormone from the pituitary
gland
2. Interfere with follicle maturation
3. Inhibit ovulation

Front 32

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Acetaminophen:
1. Has a metabolite which produces hepatic toxicity
2. Toxicity is increased in individuals who drink sufficient ethanol to induce the liver enzyme
which metabolizes acetaminophen
3. Is a therapeutically useful, antipyretic agent
4. Prolongs bleeding time in a manner and amount similar to aspirin.

Back 32

A
1. Has a metabolite which produces hepatic toxicity
2. Toxicity is increased in individuals who drink sufficient ethanol to induce the liver enzyme
which metabolizes acetaminophen
3. Is a therapeutically useful, antipyretic agent

Front 33

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Cyclooxygenase 2 (COX-2) is:
1. A constitutive enzyme in many cell types including “inflammatory cells”
2. Inhibited by agents synthesized at sites of inflammation
3. Important in normal physiology of the mucosa of the gastrointestinal tract
4. Inhibited by aspirin.

Back 33

D. 4. Inhibited by aspirin.

Front 34

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Levonorgestrel:
1. Mimics progesterone
2. Has different side effects when used as a contraceptive pill than when used as a
contraceptive patch
3. Inhibits ovulation through actions in the anterior pituitary
4. Is an effective contraceptive drug through actions as an antagonist at progesterone
receptors.

Back 34

B.
1. Mimics progesterone
3. Inhibits ovulation through actions in the anterior pituitary

Front 35

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

The advantage of chronic use of celecoxib (CELEBREX) for treatment of arthritis pain (compared
to use of aspirin) is that:
1. Celecoxib inhibits COX-1 but not COX-2
2. Celecoxib is concentrated in the joints
3. Celecoxib is not a cycloxygenase inhibitor
4. Celecoxib inhibits COX-2 but not COX-1.

Back 35

D. 4. Celecoxib inhibits COX-2 but not COX-1.

Front 36

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

The following are signs of overdose with morphine:
1. Miosis
2. Decreased respiration
3. Coma
4. Hypothermia

Back 36

E.
1. Miosis
2. Decreased respiration
3. Coma
4. Hypothermia

Front 37

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Clozapine (CLOZARIL) is known as an atypical antipsychotic agent because:
1. It is an agonist at dopamine receptors in the brain
2. It is not an antagonist at dopamine receptors in the brain
3. It produces elevated body temperature in many patients
4. It produces few, so-called extrapyramidal side effects

Back 37

D. 4. It produces few, so-called extrapyramidal side effects

Front 38

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Side effects of the use of haloperidol (HALDOL):
1. Apparent inhibition of the parasympathetic nervous system (e.g., dry mouth)
2. Mania
3. Sedation
4. Apparent activation of parasympathetic nervous system (e.g., increased salivation)

Back 38

B
1. Apparent inhibition of the parasympathetic nervous system (e.g., dry mouth)
3. Sedation

Front 39

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Prednisone (DELTASONE) may be useful to treat:
1. Rheumatoid arthritis
2. Osteoporosis
3. Adrenocortical insufficiency
4. Hypertension.

Back 39

B
1. Rheumatoid arthritis
3. Adrenocortical insufficiency

Front 40

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Older so-called “typical” antipsychotic drugs differ from newer, “atypical” antipsychotic drugs in that
the older drugs:
1. Have greater effect on the positive signs than the negative signs of schizophrenia
2. Cause depression
3. Have more so-called extrapyramidal side effects exhibited as certain characteristic
movement abnormalities
4. Commonly produce movement disorders as a result of their action on muscarinic cholinergic receptors.

Back 40

B-
1. Have greater effect on the positive signs than the negative signs of schizophrenia
3. Have more so-called extrapyramidal side effects exhibited as certain characteristic
movement abnormalities

Front 41

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Codeine:
1. Blocks the formation of prostaglandins at the site of a wound or infection
2. Reduces sensitivity of nociceptors (“pain receptors”)
3. Blocks formation of prostaglandins in the central nervous system
4. Is used as an antitussive agent.

Back 41

D - 4. Is used as an antitussive agent.

Front 42

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

All of the following statements are correct except :
1. Selective COX-2 inhibitors have a lower tendency to cause intestinal ulcers than
nonselective COX inhibitors
2. Aspirin should not be used in children with chickenpox or other viral infections
3. Aspirin and indomethacin relieve fever by reducing prostaglandin synthesis in the
hypothalamus
4. Indomethacin causes enhanced bone marrow activity (as a side effect).

Back 42

D - 4. Indomethacin causes enhanced bone marrow activity (as a side effect).

Front 43

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Progesterone:
1. Inhibits uterine contractions
2. Is antagonized by mifepristone
3. Decreases FSH and LH secretion from the anterior pituitary gland
4. Induces ovulation.

Back 43

A
1. Inhibits uterine contractions
2. Is antagonized by mifepristone
3. Decreases FSH and LH secretion from the anterior pituitary gland

Front 44

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Forms of estradiol:
1. Is used in “hormone replacement therapy” in postmenopausal women
2. Is used (with a progestin) in “daily pill” oral contraceptives
3. Is used in “emergency, day after” oral contraceptives
4. Like any estrogen, induces bone loss and development of osteoporosis.

Back 44

A
1. Is used in “hormone replacement therapy” in postmenopausal women
2. Is used (with a progestin) in “daily pill” oral contraceptives
3. Is used in “emergency, day after” oral contraceptives

Front 45

For the following questions, select the most appropriate answer
Select (A) if 1, 2 and 3 are correct
Select (B) if 1 and 3 are correct
Select (C) if 2 and 4 are correct
Select (D) if only 4 is correct
Select (E) if 1, 2, 3 and 4 are correct

Parkinson's disease is:
1. A neurodegenerative disease in which the underlying problem is the death of cholinergic
(acetylcholine synthesizing and releasing) neurons in the brain
2. A neurodegenerative disease in which the underlying problem is the death of GABAergic
neurons in the brain
3. A neurodegenerative disease in which the underlying problem is the death of
norepinephrine neurons in the brain
4. A neurodegenerative disease in which the underlying problem is the death of (specific)
dopaminergic neurons in the brain.

Back 45

D - 4. A neurodegenerative disease in which the underlying problem is the death of (specific)
dopaminergic neurons in the brain.

Front 46

Imipramine (TOFRANIL) is used to treat:
A. Episodes of depression in bipolar disorder
B. Parkinson’s disease
C. Enuresis
D. Psychosis (schizophrenia)
E. A and C above.

Back 46

E. A and C above
A. Episodes of depression in bipolar disorder
C. Enuresis

Front 47

Buspirone (BUSPAR):
A. Is a dopamine receptor antagonist used in treatment of psychosis
B. Is a serotonin receptor antagonist used in treatment of depression
C. Is a muscarinic cholinergic receptor antagonist used in treatment of Parkinsons disease
D. Is a serotonin receptor agonist used in treatment of anxiety
E. A and C, above.

Back 47

D. Is a serotonin receptor agonist used in treatment of anxiety

Front 48

Parkinson's disease may be successfully treated with:
A. Selegiline (ELDEPRYL)
B. Haloperidol (HALDOL)
C. Fluoxetine (PROZAC)
D. Buspirone (BUSPAR)
E. A and C above.

Back 48

A. Selegiline (ELDEPRYL)

Front 49

Which of the following is a competitive pharmacological antagonist at the same binding site where
phenobarbital (LUMINAL) can be considered to be an agonist?
A. Propranolol (INDERAL)
B. Flumazenil (ROMAZICON)
C. Thiopental (PENTOTHAL)
D. Diazepam (VALIUM)
E. None of the above.

Back 49

E. None of the above.

Front 50

Isocarboxazid (MARPLAN) for treatment of depression:
A. Relies on the action of these drugs to increase degradation of norepinephrine
B. Results in reduced concentrations of norepinephrine in the periphery (i.e. in the sympathetic
nervous system)
C. May cause hypertensive crisis as a result of “drug interactions” when foods such as cheese
and chocolate are consumed
D. Relies on the action of these drugs as sedatives
E. A and C above

Back 50

C. May cause hypertensive crisis as a result of “drug interactions” when foods such as cheese and chocolate are consumed

Front 51

Carbidopa is used in conjunction with levodopa in treatment of Parkinson’s Disease because:
A. Carbidopa reduces the potential psychosis-inducing effects of levodopa
B. Carbidopa reduces the proportion of each dose of levodopa being converted to
norepinephrine in postganglionic sympathetic neurons
C. Carbidopa increases the proportion of each dose of levodopa being converted to
norepinephrine in postganglionic sympathetic neurons
D. Carbidopa reduces levodopa uptake into norepinephrine synthesizing and secreting
neurons in the central nervous system.

Back 51

B. Carbidopa reduces the proportion of each dose of levodopa being converted to
norepinephrine in postganglionic sympathetic neurons

Front 52

Steroid hormone receptors:
A. Are cytosolic (i.e., are located in the cytoplasm)
B. Are embedded in the plasma membrane
C. When activated, alter protein synthesis
D. Mediate responses which terminate rapidly when steroid agonist concentration is decreased
E. A and C above.

Back 52

E. A and C above.
A. Are cytosolic (i.e., are located in the cytoplasm)
C. When activated, alter protein synthesis

Front 53

Mifepristone :
A. Is an estrogen receptor antagonist
B. Prevents uterine contractions induced by progesterone
C. Inhibits ovulation
D Is a progesterone receptor antagonist
E. A and C above.

Back 53

D Is a progesterone receptor antagonist

Front 54

Cushingoid signs are:
A. Caused by excessive glucocorticoid concentration in the plasma
B. Characterized by a lack of development of the secondary sex organs at puberty
C. A sign of hormone imbalance the opposite to that of Addison’s disease
D. Can be the result of the inability of certain cells in the anterior pituitary gland to secrete
adrenocorticotrophic hormone (ACTH)
E. A and C, above.

Back 54

E. A and C, above
A. Caused by excessive glucocorticoid concentration in the plasma
C. A sign of hormone imbalance the opposite to that of Addison’s disease
.

Front 55

A drug that inhibits degradation of dopamine released from dopaminergic neurons (without affecting
dopamine synthesis or release) and that is used in the treatment of Parkinson's disease:
A. Selegiline (ELDEPRYL)
B. Bromocriptine (PARLODEL)
C. Amantadine (SYMMETREL)
D. Levodopa (DOPA)
E. A and C, above.

Back 55

A. Selegiline (ELDEPRYL)

Front 56

Which of the following statements about benzodiazepines (BZs) is incorrect?
A. BZ effects are reversed by flumazenil (ROMAZICON)
B. BZs have sufficiently rapid effects to be useful to treat acute, ongoing episodes of anxiety
C. BZs can produce muscle relaxation by effects at the neuromuscular junction
D. BZs are used as anti-epileptic drugs
E. A and C above.

Back 56

C. BZs can produce muscle relaxation by effects at the neuromuscular junction

Front 57

Zolpidem (AMBIEN):
A. Is a hypnotic (sleep-inducing) drug that will compete with alprazolam to bind to the
benzodiazepine binding site of the GABAA receptor
B. Is a hypnotic (sleep-inducing) drug that will compete with phenobarbital to bind to the
barbiturate binding site of the GABAA receptor
C. Is an “atypical” antipsychotic drug
D. Is an antidepressant drug with the same mechanism of action as imipramine

Back 57

E. A and C.

A. Is a hypnotic (sleep-inducing) drug that will compete with alprazolam to bind to the
benzodiazepine binding site of the GABAA receptor

C. Is an “atypical” antipsychotic drug

Front 58

Buproprion:
A. Is marketed and prescribed as WELLBUTRIN for treatment of depression
B. Is a benzodiazepine used to treat insomnia and anxiety
C. Is marketed and prescribed as ZYBAN for use in helping people quit tobacco smoking
D. Is a dopamine receptor agonist used to treat schizophrenia
E. A and C, above.

Back 58

E. A and C, above.
A. Is marketed and prescribed as WELLBUTRIN for treatment of depression

C. Is marketed and prescribed as ZYBAN for use in helping people quit tobacco smoking

Front 59

Ibuprofen (MOTRIN, ADVIL, NUPRIN):
A. Is useful an analgesic because it activates opiate receptors
B. Inhibits lipoxygenase
C. Is used to treat pain associated with arthritis
D. Is a steroidal antiinflammatory agent
E. A and C

Back 59

C. Is used to treat pain associated with arthritis

Front 60

Clonazepam:
A. Is an excellent drug for treatment of insomnia because it has a short duration of action
B. Is a barbiturate used to treat epilepsy
C. Is used to treat unipolar depression
D. Has along duration of action although it has no active metabolites
E. A and C above

Back 60

D. Has along duration of action although it has no active metabolites