Pharmacotherapeutics, Pharmacokinetics, & Pharmacodynamics

Front 1

What is the 6th right

Back 1

The indication (pharmacotherapeutics)
The reason

Front 2

The 4 steps of pharmacokinetics

Back 2

1. Absorption
2. Distribution
3. Metabolism
4. Excretion

Front 3

Blood flow
Protein binding
Blood-brain barrier
Are all components of what process?

Back 3

Distribution
(Under Pharmacokinetics)

Front 4

First pass effect
P-450 system
Are both components of what process?

Back 4

Metabolism
(Under Pharmacokinetics)

Front 5

Half life
Steady state
Clearance
Are all components of what process?

Back 5

Excretion
(Under Pharmacokinetics)

Front 6

The three components to Pharmacodynamics

Back 6

1. Potency & Efficiency
2. Maintenance & Loading doses
3. Therapeutic Index

Front 7

What type of drug preparations are the most common?

Back 7

enteral (oral)

Front 8

enteral

Back 8

Means: by way of intestine

Front 9

Most enteral drugs will be absorbed in the

Back 9

small intestines

Front 10

During drug administration, what is the most complicated pathway?

Back 10

PO

Front 11

Three steps a PO drug must go through to become available for the body to use?

Back 11

Tablet -->
disintegration-->
dissolution
(must be broken down into solution)

Front 12

rate limiting

Back 12

rate the PO drug takes to disintegrate and dissolve to become available for the body to use (liquid is faster than tablet)

Front 13

Parenteral

Back 13

besides the way of the intestine (IV, IM, or SubCut)

Front 14

The indication for giving a drug is also referred to as (2 things)

Back 14

6th right and pharmacotheraputics

Front 15

The effect of the body on the drug.

Back 15

PHARMACOKINETIC

Front 16

________ is the movement of the drug from the site of administration into the bloodstream.

Back 16

Absorption

Front 17

_________ is the movement of the drug into the cells.

Back 17

Distribution

Front 18

________ is the conversion of the drug into another substance or substances.

Back 18

Metabolism

Front 19

_________ is the removal of the drug.

Back 19

Excretion

Front 20

Several variables affect the rate of drug absorption. Depends on the ____ of administration, ____ _____, and __ of environment

Back 20

route of administration, blood flow, and pH of environemnt

Front 21

Drugs that are administered ____ generally take the longest to be absorbed.
____ or other ____ can interfere with absorption.

Back 21

orally

Food drugs

Front 22

Enteric-coated tablets are the ______ of the oral preparations

Back 22

slowest

Front 23

3 ways a drug moves into our cells

Back 23

1. Active transport
2. Passive transport
3. penocytosis (a form of active transport)

Front 24

Biotransformation is also called

Back 24

metabolism

Front 25

Onset, Peak, and Duration all fall under the _________ category

Back 25

Pharmacokinetic

Front 26

In low pH environments drugs are broken down ______

Back 26

faster

Front 27

Very young and old have low gastric acid so there is _____ absorption of drugs

Back 27

slow

Front 28

How does constipation affect drug absorption?

Back 28

Drug will stay in system longer so there is more chance for toxicity

Front 29

Why do we always assess GI motility status when giving meds?

Back 29

To assess speed of absorption and avoid toxicity. Esp in Geri patients who have slower gastric motility