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15 Cards in this Set
- Front
- Back
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What are the signs and symptoms of Parkinson's disease? (4)
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resting tremor
bradykinesia muscle rigidity postural instability |
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What is the pathophysiology of Parkinson's disease?
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degeneration of neuromelanin-containing dopaminergic neurons of the substantia nigra pars compacta (to corpus striatum)
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Draw the chart of the substantia nigra and corpus striatum
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Good job!
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Loss of what type of neurons results in Parkinson's disease?
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dopaminergic neurons
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In the absence of dopamine, what other neuron type becomes responsible for actions on GABAergic neurons in the corpus striatum?
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cholinergic (+) neurons
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What effect do dopaminergic neurons have on GABAergic neurons in the corpus striatum?
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inhibitory (-)
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Which drug is the first-line treatment for Parkinson's?
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levodopa (with carbidopa)
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What drug is a precursor to dopamine?
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levodopa
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What drug inhibits dopa decarboxylase?
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carbidopa
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Most effects of levodopa appear to be mediated by stimulation of what receptors in the striatum?
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D2 receptors
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Which class of drugs could lead to hypertensive crisis when given with levodopa?
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MAO-I's
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What are some other dopamine agonists for Parkinson's? (4)
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Bromocriptine - D2
Pergolide - D2, D1 Pramipexole - D3 Ropinirole - D2 |
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Which drug classes inhibit the breakdown of dopamine? (2)
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MAO-I's
COMT inhibitors |
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What are the two (2) MAO-I's?
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selegeline
rosagiline |
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What are the two (2) COMT inhibitors?
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entacapone
tolcapone |
