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13 Cards in this Set
- Front
- Back
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How is Huntington's disease contracted?
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dominantly inherited (genetic)
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What is the specific cause of Huntington's disease?
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abnormal polyglutamine expansion within protein Huntingtin
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What part of the brain degenerates in Huntington's?
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striatum
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What type of neurons are targeted in Huntington's therapy?
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dopamine neurons
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What are the two mechanisms of dopamine therapy for Huntington's?
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deplete central monoamines (dopamine)
block dopamine receptors |
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What are two (2) drugs that deplete central monoamines?
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reserpine
tetrabenzene |
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What are two (2) drugs that block dopamine receptors?
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perphenazine
haloperidol |
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Which drug is contraindicated in Huntington's?
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levodopa
(exacerbates it) |
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Antidepressants with which type of side effects should be avoided in Huntington's?
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antidepressants with significant cholinergic effects (fluoxetine, carbamazepine)
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What might be the cause of ALS?
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toxic gain of function mutation in superoxide dismutase
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What is the pathophysiology of ALS?
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degeneration of motor neurons of the spinal cord and the cortical neurons that provide input to them (muscle neurons)
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What is responsible for death in most ALS patients?
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respiratory compromise
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What is used to treat ALS?
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Baclofen - GABAb agonist helps with spasticity
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