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39 Cards in this Set
- Front
- Back
Which of the following routes bypasses the drug absorption phase?
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Intravenous
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Most drugs are absorbed in the intestine by which of the following processes?
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Passive non-ionic diffusion
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All of the following help determine the rate and extent of drug absorption EXCEPT
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Potency
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Bioavailability (Foral) is?
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The fraction of a drug's dose that is absorbed
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Which of the following organs is a drug perfused least rapidly?
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Adipose Tissue
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In the mythical 70 kg man, a drug that is distributed into total body water has an approximate Vd of ?
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40 L
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Probenicid blocks secretion of penicillin from kidney tubules into urine. If a px on penicillin is subsequently given probenicid, which changes would occur in penicillin?
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Decreased Cl
Probenicid is a substrate for Weak Organic Acid (WOA) Transporters. Its administration inhibits secretion of many drugs. |
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Phase I metabolism of drugs may involve all EXCEPT?
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Conjugation with a hydrophilic substance
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Metabolism of active drug may do any EXCEPT?
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Decrease the drug Vd
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Drugs which are very rapidly metabolized by the liver most likely exhibit?
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Poor bioavailability
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Which of the following is the least important property of drug?
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Potency
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The therapeutic index of a drug measures?
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Potency of therapeutic effect vs potency of toxic effect
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Induction of drug metabolism may result in all EXCEPT?
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Decreased Vd
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14. Compared to its density (# per cell) at the resting state, the density of a B-adrenergic receptor on vascular smooth muscle will likely?
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Decrease during chronic administration of agonist
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Log Dose-Response Curve for drug action obeys the Law of Mass Action. The following about this relationship are correct for graded log-dose-response curve EXCEPT
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“effect” may refer to the range of a physiological responses with a group of individuals to a given dose of drug
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T1/2 = ?
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Vd/Cl
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Which of the following is most important factor in determining the absorption of a drug?
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Concentration of uncharged form in the intestine
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Drug A has very short T ½. Of the following, which is most compatible with a short T ½?
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Extensive first pass metabolism
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Drug A inhibits the biotransformation of B. If B is active form, coadministration of A will have what effect on B?
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Shortens its duration of action
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Which of the following properties of a drug is most closely associated with its ability to cross blood-brain barrier?
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Lipid Solubility
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Drug that is highly charged and very water soluble is likely to display which of the following:?
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Low Foral
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A drug that can have all of the following properties with regard to receptors EXCEPT?
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Cause up-regulation of a receptor if it is an agonist of that receptor
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All of the following regarding kidney handling of drugs are correct EXCEPT
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Lipid soluble drugs are reabsorbed by specific active transport systems
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Drug X is metabolized in liver by P450 to an inactive compound. Drug Z is then added to px regime. Drug Z induces metabolism of Drug X by P450. 2 weeks after Z begins, which statement comparing to BEFORE Z begins is correct?
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Blood levels of X are decreased
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Hepatic first pass metabolism of drugs is most significant after which route?
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Oral
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All are true of P450 reactions EXCEPT?
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Utilize ATP as substrate
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Formation of acetaminophen glucuronide is described by each of the following EXCEPT
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Its necessary for further acetaminophen metabolism by P450
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step reaction Codeine --> Morphine --> Morphine-O-sulfate is characterized by which?
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BOTH Metabolic drug activation and formation of water soluble metabolite
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An agonist is a chemical substance that?
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Binds to a specific receptor and initiates a response
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Which of the following statements best describes the toxicity of most drugs?
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Toxicity is often an extension of desired effect
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Which statement concerning a drug's properties is Correct?
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The effects of a competitive antagonist are reversible
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Classification of hormone and neurotransmitter receptors into different groups is predominately done by measurement of?
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Rank order of potency of a series of agonists and antagonists
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Drug with Vd of 500 is likely?
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Primarily in muscle and fat
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Which is a correct statement about pharmacokinetic or pharmacodynamic parameters?
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Cl is the constant fraction of a drug cleared per unit time
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All statements are correct about drug distribution Except?
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The rate of movement of water soluble drugs across capillaries is directly proportional to the number of capillary transport systems for that drug
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A collection of drugs binds to receptor X. 99% of X is in the inactive state in absence of agonist. Which statement concerning properties of drugs is Correct?
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Partial agonists will activate the receptor more than inverse agonist
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Which would NOT delay the metabolic transformation of a drug?
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Receptor desensitization
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Thiopental is very lipid soluble. Which contributes to the short duration of anesthetic action of a single dose of thiopental?
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Rapid accumulation in fat
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Hepatic blood flow and intrinsic hepatic clearance (Metabolism) are important factors in clearance of drugs with which properties?
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Extensive reabsorption in kidney
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