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15 Cards in this Set
- Front
- Back
structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artificial ventilation; full doses lead to respiratory paralysis and require ventilation
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neuromuscular blocking drugs
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these drugs strongly potentiate and prolong the effect of neuromuscular blockade
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inhaled anesthetics esp. isoflurane aminoglycasides
antiarrythmics |
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these prevent the action of Ach at the skeletal muscle endplate to produce a "surmountable blockade"
effect is reversed by cholinesterase inhibitors- pyridostigmine and neostigmine |
nondepolarizing type antagonists
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agent with long duration of action and is most likely to cause histamine release
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tubocurarine
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non-depolarizing skeletal muscle antagonist that has short action
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mivacurium
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agent can block muscarinic receptors
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pancuronium
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agent undergoing Hofmann elimination (breaking down spontaneously)
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atracurium
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one depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis,
causes muscle pain and mygolobinuria may occur |
succinylcholine
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during phase I these agents worsen the paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine
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cholinesterase inhibitors
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agents acting in CNS or in skeletal muscle, used to reduce abnormally elevated tone caused by neurologic or muscle endplate disease
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spasmolytic drugs
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facilitates GABA presynaptic inhibition
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diazepam
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GABA agonist in spinal cord
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baclofen
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similar to clonidine and may cause hypotension
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tizanidine
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DOC for malignant hyperthermia by acting on the sarcoplastmic reticulum or skeletal muscle
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Dantrolene
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agent used for acute muscle spasm
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cyclobenzaprine
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