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38 Cards in this Set
- Front
- Back
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AChE Inhibitors
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Organophosphates (irreversible)
Carbamate (reversible) |
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Modify Na+ Channels (open) -> Neuroexcitement
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Pyrethroids
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MAO inhibitor/
Octopamine Agonist/ Alpha 2 Antagonist |
Amidines
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Growth Regulation Disruptors
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Cyromazine
Benzayl Urea Derivatives |
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Blocks GABA gates Cl- Channels
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Fipronil
Pyriprole |
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Binds to CNS nicotinic receptors
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Imidacloprid
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Interfere with ion transport across cell membranes
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Ionophores
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Coccidiostat that competes with PABA in folic acid cascade
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Sulphonamides
Ethopabate |
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Inhibits Dihydrofolate reductase in folic acid cascade
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Diaminopyrimidines
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Disrupts electron transport
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Quinolones
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Binds to nematode tubulin
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Benzimidazoles
Pro-benzimidazoles |
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Hyperpolarization @ Neuromuscular Junction
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Piperazine
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Latrophilin receptor (new family) G-Protein Receptor ->flaccid paralysis
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Emodepside (Cyclo-depsipeptides)
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Ca+ influx ->tetanic contraction (Cestode)
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Praziquantel
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Inhibits glycolytic pathways (Flukacide)
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Sulphonomide-Clorsuian(Antibiotic)
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Uncouples Oxidative Phosphorylation
(Anti-coccidial) |
Dinitolmide
Nicarbazin Robenidine |
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Uncouples Oxidative Phosphorylation
(Flukacide) |
Salicylanilides
Nitroxynil |
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Act @ Ach/Nicotinic receptors in parasite ganglia
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Imidazothiazoles
Tetrahydropyrimidines |
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Potentiates GABA @ receptor site (Cl- Channels)
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Milbemycin
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Acts on glutamate gated Cl- Channels
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Avermectin (also an Endectocides)
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Inhibits transpeptidase enzyme in cell wall
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Beta Lactams
* Penicillin * Cephlosporins (Beta lactamase resistant) Bacitracin |
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Inhibits bacterial protein synthesis
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* Thiostrepton
* 50S Subunit Macrolides Lincosamides Chloramphenicols * 30S Subunit Tetracyclines Aminoglycosides Fusidic Acid |
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Competes with PABA in folic acid cascade
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Sulphonamides
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Inhibits dihydrofolate reductase (DHFR) in folic acid cascade
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Diaminopyrimidines
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Inhibits bacterial DNA gyrase (break DNA for transcription)
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Fluoroquinones
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Inhibits bacterial nucleic acid function
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Nitroimidazoles
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Inhibits RNA polymerase
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Rifampin
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Disrupts microbial cell membrane phospholipids (detergent like)
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Polymyxins
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Inhibits nucleic acid synthesis
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Novobiocin
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Disrupts mitotic spindle of fungal cells
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Griseofulvin
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Disrupts fungal RNA or DNA
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Flucytosine
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Anti fungal - Mechanism unclear
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Iodides
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Inhibits squalene epoxidase by reducing ergosterol production
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Terbinafine
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Binds to ergosterol in fungal cell membrane causing disruption
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Amphotericin B
Azoles Nystatin Natamycin |
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Inhibits viral DNA polymerase
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Acyclovir
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Antiviral - Mechanism of action unclear
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Amantadine
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Interefers with translation (protein production) disrupting viral mRNA
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Omega interferons
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Inhibits viral RNA dependent DNA polymerase
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Zidovudine (AZT)
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