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11 Cards in this Set
- Front
- Back
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cardio drug that causes hemolytic anemia
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quinidine
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tx for GERD in a diabetic
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prochlorperazine
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tx for anxiety
with minimal sedation effect |
buspirone
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antineoplastic drug that causes blood in urine
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cyclophosphamide;
hemorrhagic cystitis |
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bleomycin SE
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pulmonary toxicity
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bleomycin is tx for
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lymphoma and testicular tumors
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cisplatin SE
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nephrotoxicity
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cisplatin is tx for
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testicular and lung cancers
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doxorubicin SE
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cardiotoxicity
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mechanism of doxorubicin cardiotoxicity
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decline in mitochondrial oxidative phosphorylation. Reactive oxygen species, generated by the interaction of doxorubicin with iron, can then damage the myocytes (heart cells), causing myofibrillar loss and cytoplasmic vacuolization
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equation:
how do you determine half life from: clearance and volume of distribution |
Clearance = k x Vd
Half life = 0.7/k |
