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15 Cards in this Set
- Front
- Back
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1/2 life?
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0.693xVd
/ Cl |
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Vd (volume of distribution)?
**often expressed as L/Kg (calculate w/ body weight) |
dose x F (bioavailability)
/ Initial concentration |
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Clearance?
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rate of elimination
/ Drug concentration |
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Cpss (steady state drug concentration)
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Dose x F
/ Interval x Cl |
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Initial concentration achieved
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Dose x F
/ Vd **derived from above equation solving volume distribution |
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What happens if FIRST PASS EFFECT impacted?
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F increases and clearance decreases
-->serum concentration (Cssp) increases x 4 |
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weak acids bind to ?
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albumin
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weak bases bind to?
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alpha-1-acid glycoproteins
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Phase I rxns
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dealkylation
hydroxylation oxidation reduction hydrolysis |
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phase II rxns
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addition of...
-glucuronic acid -sulfate -glutathione -aa -acetate |
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catalyze most oxidation, reduction, and hydrolysis reactions
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microsomal
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what kind of conjugation does microsomal do?
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glucuronide only
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enzyme induction w/ microsomal or non-microsomal?
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micrsomal
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Nonmicrocomal --> what kind of conjugations?
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all but GLUCORONIDE
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Proximal tubule or distal tubule --> specific transport systems?
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Proximal --> nonspecific
Distal-->specific |
