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133 Cards in this Set

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acetaminophen

Tylenol


Tempra

Other names

acetaminophen CLASS

Non-opioid analgesic; Antipyretic

acetaminophen ACTIONS

1. Inhibits the synthesis of prostaglandins that may serve as meditators of pain and fever; does not have significant anti inflammatory properties


2. Inhibits prostaglandin synthesis in the CNS by blocking pain impulse generation


3. Acts on the hypothalamic heat regulating centre to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating, and heat loss

acetaminophen INDICATIONS

1. Treatment of mild pain


2. Reduction of fever

acetaminophen CONTRAINDICATIONS

1. Hypersensitivity to alcohol, aspartame, saccharin, sugar, or FDC yellow dye #5 (food colouring)


2. Active liver disease/hepatic impairment

acetaminophen DOSAGE

Adult: 975 mg PO- Do not repeat dose


Paediatric: 15mg/kg PO to max of 975mg

acetaminophen SIDE EFFECTS

Renal failure with high doses/chronic use

acetaminophen PHARMACOKINETICS

Onset of Action: 15-30 mins


Duration: 4-6 hours

acetaminophen CONSIDERATIONS

1. Don’t administer if patient has taken max dose within 4 hours


2. If patient has received less than max dose within 4 hours only administer to max dose


3. Document temperature before administration

acetaminophen TOXIC LEVELS

Adult >150mg/kg or dose of 7.5g


Paediatric >150 mg/kg

acetylsalicylic acid

ASA


Aspirin


Bufferin

acetylsalicylic acid CLASS

Antiplatelet


Analgesic


Antipyretic


Anti-inflammatory


Nonsteroidal Anti-inflammatory Drug (NSAID)

acetylsalicylic acid ACTIONS

1. Blocks formation of thromboxane A2, which is responsible for platelet aggregating and arteries constricting


2. Produces analgesia and has anti-inflammatory, and antipyretic effects by inhibiting the production of prostaglandins

acetylsalicylic acid INDICATIONS

Anti-platelet therapy in Acute Coronary Syndrome (ACS)

acetylsalicylic acid CONTRAINDICATIONS

1. Hypersensitivity to salicylates/ NSAIDS


2. Unconscious/ unable to follow commands


3. Patients with active ulcer disease (GI hemorrhage)


4. Bleeding disorders


5. Pregnancy (3rd trimester)


6. Children under 15


7. ASA induced asthma

acetylsalicylic acid DOSAGE

Adult: 160mg (162mg) PO chewed. That is the Max


Paediatric: N/A

acetylsalicylic acid SIDE EFFECTS

1. GI irritation


2. Nausea/ Vomiting


3. Tinnitus


4. Increased risk of bleeding

acetylsalicylic acid PHARMACOKINETICS

Onset: 1-2hours


Duration: 4-5 hours

acetylsalicylic acid CONSIDERATIONS

1. If confirmed patient took ASA properly prior


2. ASA still administered with daily dose or on blood thinners


3. Patients receiving anticoagulant therapy


4. Diabetics taking ASA and oral hypoglycaemic or insulin should be closely monitored for hypoglycaemia


5. Reye’s Syndrome is an acute, often fatal disease of childhood, characterized as acute edema of the brain, hypoglycaemia, fatty infiltration, and liver dysfunction

dextrose in water

D10W


D25W


D50W

dextrose in water CLASS

Caloric agent

dextrose in water ACTIONS

1. Increase blood sugar levels to normal cases in hypoglycemia


2. Hypertonic solutions producing a transient movement of water from interstitial spaces into the venous system (osmotic diuretic)

dextrose in water INDICATIONS

1. Severe, symptomatic hypoglycaemia from any cause


2. Head injury with symptomatic hypoglycemia (1/2 dose)


3. Stroke with symptomatic hypoglycemia (1/2 dose)

dextrose in water CONTRAINDICATIONS

1. Allergy to corn/corn products


2. Hyperglycemia


3. Hypersensitivity to dextrose solution


4. Relative contraindication- intracranial hemorrhage (1/2 the dose)

dextrose in water DOSAGES

Adult: 25g D50W SIVP/IO q5min prn


Titrate to BGL >/=4.0mmol/L or patient improvement to max 50g


Adult Sus Stroke: 12.5g D50W SIVP/IO q5min prn


Titrate to BGL >/=3.0mmol/L or patient improvement to max 50g


Adult Sus Head Ouch: 12.5g D50W SIVP/IO q5min prn


Titrate to BGL >/=4.0mmol/L or patient improvement to max 50g


Pediatric: (Less than 10kg) 0.5g/kg D10W SIVP/IO q5min prn


Titrate to BGL >=4.0mmol/L or patient improvement


(More than 10kg less thank 40kg) 0.5g/kg D25W SIVP/IO to a single max dose of 12.5g q5min


Titrate to BGL >=4.0mmol/L or patient improvement


(More than/equal to 40kg) 12.5g D50W SIVP/IO q5min prn, single max dose


Titrate to BGL >=4.0mmol/L or patient improvement

dextrose in water SIDE EFFECTS

1. Rebound hyperglycemia


2. May aggravate hypertension and CHF


3. May cause neurological symptoms in alcoholic patient


4. Wernicke’s encephalopathy/Korsakoff’s syndrome

dextrose in water PHARMACOKINETICS

Onset: <1 minute


Duration: Varies

dextrose in water CONSIDERATIONS

1. Tissue death if infiltration occurs


2. Utilize large bore catheter in a large vein


3. D50W has short duration of action- follow admin with eating carbohydrates


4. Serve neurological symptoms in alcoholics- give thiamine prior to D50W (ACP)


5. Increased intercellular glucose levels in the setting of cerebral ischemia and hypoxia- increased intercellular acidosis due to anaerobic metabolism of glucose & subsequent neuronal death

dimenhyDRINATE

Gravel

dimenhyDRINATE

Gravol

dimenhyDRINATE CLASS

Antiemetic

dimenhyDRINATE ACTIONS

1. Depress vestibular (equilibrium) function by inhibiting histamine H1 receptors


2. Sedative effects due to inhibition of histamine

dimenhyDRINATE INDICATIONS

Nausea and vomiting associated with motion sickness and vertigo

dimenhyDRINATE CONTRAINDICATION

1. Hypersensitivity to dimenhyDRINATE and diphenhydramine or propylene glycol (food additive)


2. Narrow angle glaucoma


3. Patient who have ingested large quantities of depressants including alcohol

dimenhyDRINATE DOSAGES

Adult: 50mg SIVP/IM q4 hours


25mg SIVP/IM for patients over 65 years old prn q15mins. MAX 50mg


Pediatric: N/A

dimenhyDRINATE SIDE EFFECTS

1. Drowsiness


2. Sedative effect

dimenhyDRINATE PHARMACOKINETICS

Onset: IV immediate; IM 20-30 min


Duration of Action: 3-6 hours

dimenhyDRINATE CONSIDERATIONS

1. Generally administered in 10mL syringe with NS for IV administration; lessens vein irritation


2. Preferred antiemetic for nausea & vomiting associated with vertigo, motion sickness or narcotic side effect

diphenhydrAMINE

Benadryl

diphenhydrAMINE CLASS

Antihistamine

diphenhydrAMINE ACTIONS

1. Competes with histamine for H1 receptor sites of effector cells. - prevent but do not reverse responses mediated by histamine alone


2. Does not inhibit histamine release


H1: increased bronchial & nasal secretions


Constriction of bronchioles


Stimulation of sensory nerve endings (itching)

diphenhydrAMINE INDICATIONS

1. Allergic reactions


2. Adjunct to epinephrine in anaphylaxis management


3. Management of drug induced extrapyramidal symptoms

diphenhydrAMINE CONTRAINDICATIONS

1. Hypersensitivity to diphenhydramine or dimenhyDRINATE


2. Relative: avoid antihistamine in musing mothers/neonates unless life threatening anaphylaxis

diphenhydrAMINE DOSAGES

Adult: (ELIXIR) 50mg PO- Do not repeat dose


1mg/kg IM/SIVP/IO, single max dose 50mg - Do not repeat dose (IM Vastus Lasteralis)


Pediatric: (ELIXIR) 1mg/kg PO, single max dose of 50mg -Do not repeat dose


1mg/kg SIVP/IM/IO, single max dose 50mg- Do not repeat dose (IM Vastus Lateralis)

diphenhydrAMINE SIDE EFFECTS

1.Dry mouth


2. Blurred vision


3. Hypotension


4. Thickening of bronchial secretions


5. Bronchospasm

diphenhydrAMINE PHARMACOKINETICS

Onset: PO 15min // IV&IM 5-10 min


Peak Effects: 1-4 hours

diphenhydrAMINE CONSIDERATIONS

Diphenhydramine not recommended in neonates due to increased susceptibility to anticholinergic effects however should be administered judiciously in setting of anaphylaxis

epinephrine 1mg/mL (1:1000 concentration)

Adrenalin

epinephrine CLASS

Sympathomimetic


Endogenous catecholamine

epinephrine ACTIONS

1. Inhibits the release of histamine associated with allergic & anaphylactic reactions


2. Alpha 1 agonist: Peripheral vasoconstriction improving coronary and cerebral perfusion


3. Beta 1 agonist: Positive chronotropic, inoptropic, and from Otto pic properties -increases automaticity in the heart


4. Beta 2 agonist: Bronchodilation- adrenergic receptors in the lungs to relax both bronchial smooth muscle

epinephrine INDICATIONS

Anaphylaxis

epinephrine CONTRAINDICATIONS

1. None in emergent situation


2. Hypersensitivity to epinephrine

epinephrine DOSAGES

Adult: 0.3mg (1mg/mL) IM q5min prn, max 0.9mg (Vastus Lateralis)


Pediatric: (Less than 30kg) 0.15mg IM q5min, MAX 0.45mg (Vastus Lateralis)


(More than/ equal to 30kg) 0.3mg IM q5min, MAX 0.9mg (Vastus Lateralis)

epinephrine SIDE EFFECTS

1. Palpations


2. Tremors


3. Nervousness


4. Dizziness


5. Anxiety


6. Headache


7. Hypertension


8. Tachycardia

epinephrine PHARMACOKINETICS

Onset of Action: 5-10 min (IM)


Peak Effects: 20 min

epinephrine CONSIDERATIONS

1. Must be cardiac monitored


2. Do not administer by IV


3. In pregnancy can cause fetal hypoxia


4. Ensure in recumbent position prior to administration


5. Concentration of 1mg/mL previously known as 1:1000

glucagon CLASS

Hormone

glucagon ACTIONS

Causes an increase in blood glucose by stimulating glycogen breakdown in the liver, converting glycogen to glucose

glucagon CONTRAINDICATIONS

1. Hypersensitivity to glucagon, beef, or pork proteins


2. Pheochromocytoma


3. Hyperglycemic

glucagon DOSAGES

Hypoglycemia


Adult: 1mg IM q15min prn, MAX 2mg


Pediatric: (less than 20kg) 0.5mg IM q15min prn, MAX 1mg


(More than/equal to 20kg) 1mg IM q15min prn, total max

glucagon SIDE EFFECTS

1. Dizziness


2. Headache


3. Hypertension


4. Tachycardia


5. Rebound hyperglycemia

glucagon PHARMACOKINETICS

Onset of Action: 5-15 min (IM)

glucagon CONSIDERATIONS

1. Use in patients with pheochromocytoma can cause the tumour to release catecholamines resulting in a hypertensive crisis


2. D50W is the drug of choice in hypoglycemia


3. Effective only if there are sufficient stores of glycogen within the liver


4. Eat carbohydrate after administration of meds to prevent relapse after hypoglycemia is corrected

ibuprofen

Motrin


Advil

ibuprofen CLASS

Non-steroidal anti-inflammatory drug (NSAID)


Non-Opioid analgesic

ibuprofen ACTIONS

Inhibits prostaglandin synthesis, decreasing pain and inflammatory through non-selective, reversible inhibition of the cyclooxygenase enzyme COX-1 and COX-2

ibuprofen INDICATIONS

1. Treatment of mild pain associated with arthritis or pain in muscle, joints, or bones


2. Reduction of fever for adults/children over 6 months old


3. Dysmenorrhea or headaches

ibuprofen CONTRAINDICATIONS

1. Hypersensitivity to NSAID’s/salicylates


2. Suspected intracranial bleeding


3. Sub-arachnoid hermitage (indicated by sudden onset/most severe ever headache)


4. Ibuprofen induced asthma (relative contraindications-which means that patient has had a bronchospasm reaction prior with the use)


5. History if significant renal disease, except rental colic


6. Diagnosis of crohns/ulcerative colitis/ IBD


7. Patient currently taking oral anticoagulants (Apixaban, Dabigatran, Edoxaban, Rivaroxaban, Warfarin)


8. Patient currently undergoing chemotherapy


9. Pregnancy

ibuprofen DOSAGES

Adult: 400mg PO- Do not repeat dose


Pediatric: 10mg/kg PO, Max 400mg

ibuprofen SIDE EFFECTS

1. Mild hypertension


2. GI irritation


3. Nausea/vomiting


4. Constipation


5. Tinnitus


6. Increased risk of bleeding

ibuprofen PHARMACOKINETICS

Onset: 30 mins


Duration of Action: 4-8 hours

ibuprofen CONSIDERATIONS

1. Don’t administer if Max dose reached within 6 hours


2. If stormy received less than max does in 6 hours admin up to only max dose


3. Works well for pain associated with renal colic, dental or musculoskeletal


4. Use caution with patients who have past medical history of


Recent trauma or suspected subarachnoid hemorrhage


Renal impairment


GI bleed


CHF


Elderly


Chronic alcoholics

ipratropium bromide

Striven

ipratropium bromide

Atrovent

ipratropium bromide CLASS

Anticholinergic bronchodilator

ipratropium bromide ACTIONS

1. Derivative of atropine


2. Exerts anticholinergic action in the bronchioles, inhibiting bronchoconstriction


3. Blocks increased mucus secretions

ipratropium bromide INDICATIONS

1. Bronchospasms (used with salbutamol)


2. Anaphylaxis with salbutamol

ipratropium bromide CONTRAINDICATIONS

1. Hypersensitivity


2. Hypersensitivity to atropine

ipratropium bromide DOSAGES

Adult: MDI with spacer 1 puff (20mcg/puff) q30-60 sec prn, MAX 15 puffs


500 mcg q5min via NEB, MAX 1500mcg


Pediatric: (Less than 20kg) 1 puff (20mcg/puff) MDI with spacer q30-60 sec, MAX 12 puffs


250mcg via neb prn, MAX 750mcg


(More than/equal to 20kg) 1 puff (20mcg/puff) MDI with spacer q30-60 sec, MAX 15 puffs


500mcg via neb prn, MAX 1500 mcg

ipratropium bromide SIDE EFFECTS

1. Dry mouth/throat


2. Headache


3. Cough


4. Palpitations


5. Tremors


6. Dizziness

ipratropium bromide PHARMOKINETICS

Onset of Action: 5-15 mins


Peak: 1-2 hours

ipratropium bromide CONSIDERATIONS

1. Invert canister 3x prior to administration


2. Depressed cannister once in prime prior to administration directed to the floor


3. Direct patient to inhale slowly while administering and hold their breath for 5-10 sec. Repeat 1-2x


4. MDI needs min 30 seconds recharge time between puffs


5. Alternate single puffs for salbutamol during recharge periods


6. Nebulizer administration-usually combined with salbutamol to create combivent


7. nebulizer administration- use non-humidified O2 source @ 6-8L/min


8. Enhanced by other anticholinergic drugs

isotonic solutions

Normal saline 0.9%


Ringers lactate -Contains potassium


Not used for fluid resuscitation—> D5W (starts as an isotonic, then becomes hypotonic)

isotonic solutions ACTIONS

1. Have similar osmolar concentrations as plasma


2. Osmotic pressure is equal between intracellular and extracellular spaces. Resulting in less shifting of fluids between compartments.


3. For expansion of extracellular fluid volume, without altering the electrolyte concentration of the plasma

isotonic solutions INDICATIONS

1. Used to run TKVO in patients with stable vitals but where hypotension and instability can occur


2. Fluid replacement

isotonic solutions CONSIDERATIONS

1. Careful administration is necessary or results in circulatory overload


2. Lung sounds and BP must be elevated every 250mL in medical patients


3. Lung sounds and BP must be elevated every 500 mL in trauma patients


4. Lab values needed to use RL with caution in patients with hyperkalemia -this solution contains potassium

naloxone

Marian

naloxone

Narcan

naloxone CLASS

Narcotic Antagonist

naloxone ACTIONS

1. Displaces previously administered opioid analgesics from all three opioid receptor sites and competitively inhibits their actions


2. Naloxone is metabolized more quickly than most narcotics

naloxone INDICATIONS

1. Respiratory and neurologic depression, induced by opioid intoxication unresponsive to oxygen and hyperventilation


2. Decreased LOC, or coma of unknown etiology believed to be induced by narcotics

naloxone CONTRAINDICATIONS

None significant


Use with caution in the setting of mixed opioid/stimulant

naloxone DOSAGES

Adult: 0.05mg IV/IO q2min, MAX 1mg


0.8mg IM q5min prn, MAX 3.2mg


2mg IN (1mg/nostril) q3-5min prn, MAX 4mg

naloxone DOSAGES

Adult: 0.05mg IV/IO q2min, MAX 1mg


0.8mg IM q5min prn, MAX 3.2mg


2mg IN (1mg/nostril) q3-5min prn, MAX 4mg


Pediatric: 0.1mg/kg IV/IO, single max of 2mg q2min to MAX of 10mg


0.1mg/kg IM, single max dose 2mg in divided doses (1/2 required dose in each of 2 sites) q2min MAX 10mg


0.1mg/kg IN, single max dose 2mg (divide evenly into each nostril) q5min prn, MAX 4mg

naloxone SIDE EFFECTS

1. Narcotic withdrawal


2. Restlessness


3. Combative


4. Seizures

naloxone PHARMACOKINETICS

Onset: within 2 mins (IV/IO)


Duration of Action: Dependent on route, dose, amount in patient already

naloxone CONSIDERATIONS

1. Draw up 1mg in 10mL syringe. Concentration 0.1mg/mL —> give 1/2mL (0.5mL) q2min IV/IO which is a dose of 0.05 mg


2. Be prepared for combative, aggressive, or seizing patient.


3. May induce acute withdrawal symptoms in narcotic dependent parties


4. Duration of Narcan is shorter in narcotic dependent patients


5. Auscultate lungs every 250 mL of normal saline to ensure no fluid overload


6. Consider opioid triad

nitroglycerin

Nitrostat


Nitro-Bid


Nitro-Dur

nitroglycerin CLASS

Antianginal


Vasodilator

nitroglycerin ACTIONS

1. Causes relaxation of vascular, smooth muscle; dilation of both arterial and venous blood vessels, decreasing both preload and after load


2. Myocardial perfusion is increased through coronary & collateral blood vessel dilation

nitroglycerin INDICATIONS

Suspected ACS

nitroglycerin CONTRAINDICATIONS

1. Systolic BP less than 100mmHg


2. Right ventricular infarction- 12 lead message


3. Patients taking phosphodiesterase inhibitors-mandatory OLMC

nitroglycerin DOSAGES

Adult: 0.4mg SL spray q5min prn or until systolic BP less than 100mmHg


0.8mg/hr patch


0.3mg SL tablet q5min prn or until systolic BP less than 100mmHg


Pediatric: N/A

nitroglycerin SIDE EFFECTS

1. Headache


2. Hypotension


3. Dizziness/Lightheadedness


4. Nausea/Vomiting

nitroglycerin PHARMACOKINETICS

Onset: 1-3 min (SL), Patch 40-60min


Duration of Action: SL:3-60min, Patch:8-24hours

nitroglycerin CONSIDERATIONS

1. Right ventricular MI


2. Effects of nitroglycerine can be potentiated, but other vasodilators and are severely potentiated when patient have taken phosphodiesterase inhibitors in previous 24-48 hours - Call OLMC


3. Put an IV in place


4. Apply patch on left upper chest & write date & time


5. Remove patients own patch


6. If chest pain is with Brady or tachydysrhythmia contact OLMC


7. BP drops below 100mmHg maybe stop 😾

nitrous oxide

Entonox


Nitronox

nitrous oxide CLASS

Gaseous Analgesic

nitrous oxide ACTIONS

1. Rapidly reversible CNS depression and analgesia


2. Inhaled anaesthetics act on the lipid matrix of neuronal membranes. Changes the membrane thickness, which , in turn, affects the gating properties of ion channels in neurons

nitrous oxide INDICATIONS

1. Fracture/dislocation management


2. Active labor


3. Burns


4. Kidney stones

nitrous oxide CONTRAINDICATIONS

1. Inability to follow verbal instructions


2. ALOC, and/or intoxication with drugs or alcohol


3. Head injury 🤕


4. Respiratory compromise were 100% 02 is needed


5. Thoracic trauma with potential or actual pneumothorax


6. Abdominal pain and distension suspicious of bowel obstruction


7. Abdominal trauma


8. Pregnant (not including active labour)

nitrous oxide DOSAGES

Self administered prn via specialized demand valve and mask run at 15 lpm


Note PSI before use & after for amount taken by patient

nitrous oxide SIDE EFFECTS

1. Dizziness/lightheaded


2. Drowsiness


3. Headache


4. Nausea/Vomiting

nitrous oxide PHARMACOKINETICS

Onset: within 1 minute


Duration of action: elimination half like is approx. 5 mins


Effect of gas is not noticeable after a few minutes

nitrous oxide CONSIDERATIONS

1. Store and administer with cylinder horizontal


2. Can’t be used a patient deemed to require greater than 50% 02


3. Use in ventilated areas


4. Invert canister 3x prior to administration


5. Administer early in pain management as necessary, while initiating vascular access to provide pain, relief with narcotics


6. Gases me separate at -6° Celsius, resulting in improper device operation

oral glucose

Insta-Glucose


Dex 4

oral glucose CLASS

Caloric Agent

oral glucose ACTION

A simple monosaccharide used to increase circulating blood glucose levels

oral glucose INDICATIONS

Conscious patient with suspected🤨 hypoglycemia

oral glucose CONTRAINDICATIONS

1. Unconscious


2. Hyperglycemic

oral glucose DOSAGES

Adult: 25g PO q5min prn, MAX 50g


Pediatric: 25g PO; do not repeat

oral glucose SIDE EFFECTS

Nausea/Vomiting

oral glucose PHARMACOKINETICS

Onset: 5-15 min


Duration of Action: Varies

oral glucose CONSIDERATIONS

1. Ensure patient can follow commands and maintain own airway


2. Must be swallowed


3. Must eat carbohydrates after, to prevent relapse of hypoglycemia

salbutamol

Ventolin

salbutamol CLASS

Bronchodilator (Sympathomimetic)

salbutamol ACTIONS

1. Selective beta2 stimulation


2. Bronchodilation, some peripheral vasodilation, slight tachycardia


3. Beta2 selectively lost with high doses

salbutamol INDICATIONS

Bronchospasms due to asthma, COPD, anaphylaxis, or are associated with airway burn injury

salbutamol CONTRAINDICATIONS

1. Hypersensitivity


2. Uncorrected tachydysrhythmias

salbutamol DOSAGES

Adult: 1 puff MDI (100mcg/puff) with spacer q30-60 sec prn


5mg nebulozed continuously


Pediatric: (Less than 20kg) 1 puff MDI with spacer q30-60 secs, MAX 15 puffs


2.5mg nebulized, MAX 7.5mg


(More/equal to 20kg) 1 puff (100mcg/puff) MDI with spaces q30-60 secs, MAX 30 puffs


5mg nebulized repeat, MAX 15mg

salbutamol SIDE EFFECTS

1. Tremors


2. Palpitations


3. Headache


4. Tachycardia


5. Dizziness


6. Nervousness

salbutamol PHARMACOKINETICS

Onset: Less than 15 mins


Duration of Action: 2-6 hours

salbutamol CONSIDERATIONS

1. Invert canister 3x prior to administration


2. Depress canister once to prime prior to administration, directed to the floor


3. Inhale slowly well, administering and hold their breath for 5 to 10 seconds, repeat. Repeat 3x more ish


4. MDI needs 30 seconds minimum recharge time between puffs


5. Alternate single puffs with ipratropium bromide during recharge period


6. Nebulizer administration- usually combined with ipratropium bomidel to create combivent


7. Nebulizer administration- use non-humidified 02 source at 6 to 8 L in a minute


8. Often patient self medicate