Pharmacology- Adrenergic Agonists And Antagonists

Front 1

Epinephrine

Back 1

DC: Catecholamine
Route: IV
MOA: Acts on all ALPHA and BETA receptors (B>A), Short duration of action, Rapid onset
Uses: Cardiac resuscitation (B1), Hypersensitivity Rxns, Relieve bronchospasms, Reduce IOP in Glaucoma (A), Local anesthetic prolongation,
CI:
SE: Hypertension, Tachycardia, Reflex Bradycardia, Ventricular arrythmias, Tremor, Hyperglycemia
Note:

Front 2

Oxymetazoline

Back 2

DC: Non Selective ALPHA Agonist
Route:
MOA: Acts of ALPHA receptors to constrict small arterioles
Uses: Nasal Decongestant
CI:
SE: Rebound hyperemia and worsening of symptoms
Note: Loss of efficacy with chronic use

Front 3

Phenylephrine

Back 3

DC: ALPHA 1 selective agonist
Route:
MOA: Activates ALPHA 1 receptors in target area
Uses: Nasal Decongestion, Mydriatic agent, Short term hypotensive emergencies
CI:
SE:
Note:

Front 4

Apraclonodine (Iopidine)

Back 4

DC: ALPHA 2 selective agonist
Route: Topical
MOA: ALPHA 2 receptor mediated reduction in aqueous humor production
Uses: Glaucoma
CI:
SE:
Note: Does not cross the blood brain barrier

Front 5

Dopamine

Back 5

DC: BETA 1 selective agonist
Route:
MOA: Vascular D1 receptors for vasodilation, Renal D1 receptors to inhibit Na+ pump and Na+/H+ exchanger, B1 receptor for positive inotropy
Uses: Improve cardiac and renal function in critically ill patients
CI:
SE:
Note:

Front 6

Dobutamine

Back 6

DC: BETA 1 selective agonist
Route:
MOA:Works on B1 receptors to help increase inotropic effect
Uses: Short term management of cardiac decompensation (increases CO and SV w/o increases in HR or BP)
CI:
SE: Increased HR, Tremor, Decreased plasma potassium concentration, Increased plasma glucose concentration
Note:

Front 7

Albuterol (Ventolin)

Back 7

DC: BETA 2 selective agonist
Route: Inhalation
MOA: Acts on the B2 receptors in the bronchioles
Uses: Symptomatic relief of bronchospasm
CI:
SE: Increased HR, Tremor, Decreased plasma potassium concentration, Increased plasma glucose concentration
Note:

Front 8

Salmeterol (Serevent)

Back 8

DC: BETA 2 selective agonist
Route: Inhalation
MOA: Acts on B2 receptors on the bronchioles and has some anti-inflammatory properties, Prolonged duration of action, Slow onset
Uses: Symptomatic relief of bronchospasm, Nocturnal asthma
CI:
SE: Increased HR, Tremor, Decreased plasma potassium concentration, Increased plasma glucose concentration
Note:

Front 9

Ritodrine

Back 9

DC: BETA 2 selective agonist
Route: IV
MOA: Acts on B2 agonist developed specifically for use as a uterine relaxant
Uses: Stop premature labor
CI:
SE: Increased HR, Tremor, Decreased plasma potassium concentration, Increased plasma glucose concentration
Note:

Front 10

Phenoxybenzamine (DIbenzylene)

Back 10

DC: Non selective ALPHA antagonist
Route:
MOA: Irreversible antagonist at ALPHA receptors (decreased preload)
Uses: Treatment of Pheochromocytoma
CI:
SE: Postural Hypotension, Reflex tachycardia,
Note:

Front 11

Tamsulosin (Flomax)

Back 11

DC: ALPHA 1 selective antagonist
Route:
MOA: Blocks A1 receptors on the trigone, internal sphincter and prostate smooth muscle
Uses: Symptomatic relief of urethral obstruction in BPH
CI:
SE:
Note:

Front 12

Timolol (Betaoptic)

Back 12

DC: Non-selective BETA antagonist
Route:
MOA: Reduces IOP by decreasing aqueous humor production by ciliary body
Uses: Glaucoma
CI: Asthma
SE:
Note:

Front 13

Amphetamine
Methamphetamine (Desoxyn)
Dextroamphetamine (Dexedrine)
Methylphenidate (Ritalin)

Back 13

DC: Amphetamines (Indirect Acting Sympathomimetics)
Route: Oral
MOA: Inhibits dopamine vesicular transporters, Inhibits uptake 1, Inhibits Monoamine oxidase
Uses: Narcolepsy, ADHD, ADD, Appetite suppressant
CI:
SE:
Note: Can cross BBB

Front 14

Ephedrine

Back 14

DC: Mixed Acting Sympathomimetics
Route: Oral
MOA: Agonist at all adrenergic receptors, Increases release of DA and NE
Uses:
CI:
SE: Arrythmias, Headache, Insomnia, Nausea, Tremors
Note:

Front 15

A-Methyl-P-Tyrosine

Back 15

DC: Indirect Acting Sympatholytics
Route:
MOA: Inhibits tyrosine hydroxylase
Uses: Occasionally used in Pheochromocytoma
CI:
SE: Hypotension, Sedation
Note: