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42 Cards in this Set

  • Front
  • Back
action of carbachol, pilocarpine
glaucoma drugs - activates ciliary muscle of eye (open angle), pupillary sphincter (narrow angle); resistant to AChE
neostigmine, pyridostigmine, edrophonium, physostigmine, and echothiophate all do what?
increase endogenous ACh
this extremely short acting anticholinesterase is used for hte diagnos of myasthenia gravis
this anticholinesterase is used for post-op and neurogenc ileus and urinary retention, MG, and postop reversal of NM blockade
this anticholinesterase is used for glaucoma and atropine OD
symptoms of cholinesterase inhibitor poisoning
diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, and salivation
antidote for parathion/cholinesterase inhibitor poisoning?
atropine (muscarinic antagonist) plus pralidoxime (chemical antagonist used to regenerate active cholinesterase)
how do atropine, homatropine, and tropicamide affect the eye?
produce mydriasis and cycloplegia (cholinoreceptor blockers)
actions of atropine?
muscarinic antagonist - blocks SLUD
toxicity of atropine?
inccreased body temp, rapid pulse, dry mouth, dry, flushed skin, cycloplegia, constipation, disorientation
mechanism/selectivity of epinephrine?
direct general agonist (alpha 1/2, beta 1/2)
mechanism/selectivity of NE?
alpha 1/2, beta 1
mechanism/selectivity of isoproterenol?
beta 1 = beta 2
mechanism/selectivity of dopamine?
D1=D2 > B > a
mechanism/selectivity of dobutamine?
B1 > B2
mechanism of amphetamines?
indirect general agonist, rerleases stored catecholamines
mechanism of ephedrine?
indirect general agonist, rerleases stored catecholamines
mechanism/selectivity of phelylephrine?
a1 > a2
mechanism/selectivity of albuterol?
B2 > B1
mechanism of cocaine?
indirect general agonist, uptake inhibitor
mechanism of clonidine, alpha-methyldopa?
centrally acting alpha agonist, decreases central adrenergic outflow
name three a1 selective blockers
prazosin, terazosin, doxazosin
what kind of drug is mirtazapine?
alpha 2 selective blocker, used for depression
what are alpha 1 blockers used for?
hypertension, urinary retention in BPH
which is reversible: phenoxybenzamine or phentolamine?
wwhat are phenoxybenzamine and phentolamine used for?
nonselective alpha blockers used for pheochromocytoma
what are the B1 selective blockers?
acebutolol (partial agonist), betaxolol, esmolol, atenolol, metoprolol
what is a short-acting B1 blocker?
what two nonselective beta blockers are partial agonists?
pindolol, labetalol
how does timolol work in glaucoma?
decreases secretion of aqueous humor
what is the only irreversible alpha blocker?
P450 inducers?
queen barb takes phen-phen and refuses greasy carbs:
quinidine, barbiturates, phenytoin, rifampin, griseofulvin, carbamazepine
P450 inhibitors?
inhibitors stop cyber kinds from eating grapefruits:
isoniazid, sulfonamides, cimetidine, ketoconazole, erythromycin, grapefruit juice, st. john's wort
what is inhibited by disulfiram?
acetaldehyde dehydrogenase
antibiotic causing ototoxicity in pregnancy?
antibiotic that can cause acute cholestatic hepatitis in mom?
antibiotic that can cause mutagenesis?
loading dose?
Cp x Vd/F
(Cp = target plasma concentration)
maintenance dose?
Cp x CL/F
half life?
(0.7 x Vd)/CL
volume of distribution?
amount of drug in body/plasma drug concentration
rate of elimination of drug/plasma concentration of drug