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480 Cards in this Set
- Front
- Back
|
morphine
|
Mu receptor agonist
|
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codeine
|
Mu receptor agonist
|
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meperidine (Demerol)
|
Mu receptor agonist
|
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hydrocodone
– w/ APAP = Vicodin – w/ homatropine = Hycodan |
Mu receptor agonist
|
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tramadol (Ultram)
|
Mu receptor agonist
|
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tapentadol (Nucynta)
|
Mu receptor agonist
|
|
|
oxycodone
– Controlled release = Oxycontin – w/ APAP = Percocet – w/ ASA = Percodan |
Mu receptor agonist
|
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methadone
|
Mu receptor agonist
|
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hydromorphone (Dilaudid)
|
Mu receptor agonist
|
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oxymorphone
|
Mu receptor agonist
|
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levorphanol
|
Mu receptor agonist
|
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fentanyl (Duragesic, Actiq)
|
Mu receptor agonist
|
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diphenoxylate
– w/ atropine = Lomotil |
Mu receptor agonist
|
|
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loperamide (Imodium)
|
Mu receptor agonist
|
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|
paregoric
|
Mu receptor agonist
|
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DTO (deodorized tincture of opium)
|
Mu receptor agonist
|
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|
naloxone (Narcan)
|
Mu receptor antagonist
|
|
|
naltrexone
|
Mu receptor antagonist
|
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|
nalbuphine
|
Mixed agonist/antagonists
• Kappa agonists/mu antagonist |
|
|
butorphanol
|
Mixed agonist/antagonists
• Kappa agonists/mu antagonist |
|
|
pentazocine (Talwin)
– Talwin NX (pentazocine + naloxone) |
Mixed agonist/antagonists
• Kappa agonists/mu antagonist |
|
|
buprenorphine
– sublingual (Subutex) • w/ naloxone = Suboxone |
Mixed agonist/antagonist
Mu partial agonist/kappa antagonis |
|
|
Prialt (ziconotide)
|
conotoxin
T-type Ca channel blocker |
|
|
Midazolam (Versed)
|
SA BDZ
pre-op sedation, fast onset |
|
|
Triazolam (Halcion)
|
SA BDZ
Insomnia, fast onset |
|
|
Alprazolam (Xanax)
|
Intermediate acting BDZ
Anxiety, phobias Active metabolites (CYP450) |
|
|
Estazolam (Prosom)
|
Intermediate acting BDZ
Insomnia |
|
|
Lorazepam (Ativan)
|
Intermediate acting BDZ
Anxiety, status epilepticus (Glucuronidation)* |
|
|
Oxazepam (Serax)
|
Intermediate acting BDZ
Anxiety (Glucuronidation)* |
|
|
Temazepam (Restoril)
|
Intermediate acting BDZ
Insomnia Glucuronidation* |
|
|
Chlordiazepoxide (Librium)
|
LA BDZ
Anxiety, alcohol withdrawal Active metabolite CYP 450 |
|
|
Clonazepam (Klonopin)
|
LA BDZ
Seizures, acute mania |
|
|
Clorazepate (Tranxene)
|
LA BDZ
Axiety, seizures Active metabolites (CYP450) |
|
|
Diazepam (Valium)
|
LA BDZ
Anxiety, alcohol withdrawal, muscle relaxant, status epilepticus Active metabolites (CYP450) |
|
|
Flurazepam (Dalmane)
|
LA BDZ
Insomnia Active metabolites (CYP450) |
|
|
Quazepam (Doral)
|
LA BDZ
Insomnia Active metabolites (CYP450) |
|
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Flunitrazepam (Rohypnol)
|
BDZ
date rape |
|
|
Zolpidem (Ambien)
|
BDZ related drug
Selective to alpha1 GABAa insomnia |
|
|
Zaleplon (Sonata)
|
BDZ related drug
Slective to alpha1 GABAa insomnia |
|
|
Flumazenil (Romazicon)
|
BDZ antagonist, very SA
Antidote to BDZ overdose, reverse procedural sedation |
|
|
Thiopental (Pentothal)
|
Barbiturate
Ultra short acting Anesthesia, emergency seizure, ICP |
|
|
Methohexital (Brevital)
|
Barbiturate
Ultra short acting Anesthesia |
|
|
Pentobarbital (Nembutal)
|
Barbiturate
Ultra short acting Pre-op sedation |
|
|
Amobarbital (Amytal)
|
SA Barbiturate
Hypnotic, sedative |
|
|
Butabrabital (Butisol)
|
SA Barbiturate
Anxiety, insomnia |
|
|
Butalbital (Fioricet)
|
SA Barbiturate
combo w/ ASA, APAP, or caffeine Tension/muscle contraction headaches |
|
|
Mephobarbital (Mebaral)
|
SA Barbiturate
Epilepsy, sedation |
|
|
Secobarbital (Seconal)
|
SA Barbiturate
Sedation |
|
|
Phenobarbital (Luminal)
|
LA Barbiturate
Anticonvulsant, pre-op sedation |
|
|
Ramelton (Rozerem)
|
MT1, MT2 receptor agonist
Melatonin receptor doesnt work well, used for jet lag |
|
|
Buspirone (Buspar)
|
Partial 5-HT1a receptor agonist
SSRI |
|
|
Dantrolene
|
Direct acting muscle relaxant
|
|
|
Botulinium Toxin type A (BTXA)
|
Neuromuscular blocker
|
|
|
Tizanidine (Zanaflex)
|
Selective a2 receptor agonist
Short acting |
|
|
Cyclobenzaprine (Flexeril)
|
5-HT2 receptor antagonist
BLOCKS serotonin receptor SNRI Blocks NE reuptake (Anticholineric) |
|
|
Methocarbamol (Robaxin)
|
Misc central muscle relaxant
|
|
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Carisoprodol (Soma)
|
Misc central muscle relaxant
|
|
|
Orphenadrine (Norflex)
|
Misc central muscle relaxant
Atropine like effects |
|
|
Phenytoin (Dilantin)
|
Hydantoin Na channel blocker
induces CYP 2C9 and 3A4 |
|
|
Fosphenytoin (Cerebyx)
|
Hydantoin Na channel blocker
Prodrug --> Phenytoin |
|
|
Carbamazepine (Tegretol)
|
Hydantoin Na channel blocker
Induces CYP2C9 and CYP3A Metabolized by CYP 3A |
|
|
Oxcarbazepine (Trileptal)
|
Hydantoin Na channel blocker
Prodrug, decreased CYP induction |
|
|
Lamotrigine (Lamictal)
|
Na channel blocker
|
|
|
Ethosuximide (Zarontin)
|
T-type Ca channel blocker
|
|
|
Zonisamide (Zonegran)
|
T-type Ca channel blocker
|
|
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Gabapentin (Neurontin)
|
Bind specific α2 δ subunit of voltage-gated calcium channel,
reduces Ca influx mediated neurotransmitter release |
|
|
Pregabalin (Lyrica)
|
Bind specific α2 δ subunit of voltage-gated calcium channel,
reduces Ca influx mediated neurotransmitter release |
|
|
Tiagabine (Gabitril)
|
Inhibits GAT-1 transporter
|
|
|
Vigabatrin (Sabril)
|
Irreversible inhibitor of GABA-T
|
|
|
Valproic Acid
(Divalproex, Depakote) |
Na channel blocker
T-type Ca channel blocker Enhancing GABA transmission |
|
|
Levetiracetam (Keppra)
|
High-voltage gated (N-type) Ca channel blocker
|
|
|
Topiramate
|
AMPA Receptor blocker (Na channel) Glu
|
|
|
Felbamate
|
NMDA Receptor blocker (Ca channel) Glu
|
|
|
Isoflurane
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists |
|
|
Enflurane
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists |
|
|
Desflurane
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists |
|
|
Sevoflurane
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists |
|
|
Halothane
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists |
|
|
Nitrous Oxide
|
Inhalational Anesthetic
GABAA stimulation and K+ channel agonists NMDA receptor antagonist |
|
|
Thiopental
|
Intravenous Anesthetic
|
|
|
Propofol (Diprivan)
|
Intravenous Anesthetic
Voltage-gated Na+ channel blocker GABAa agonist |
|
|
Etomidate (Amidate)
|
Intravenous Anesthetic
GABAa receptor agonist |
|
|
Ketamine (Ketalar)
|
Intravenous Anesthetic
NMDA Noncompetitive Receptor blocker α1 and β1 receptor agonist Prevents re-uptake of catecholamines |
|
|
Dantrolene
|
Direct acting muscle relaxant
Inhibits release of Ca2+ release from sarcoplasmic reticulum (preventing malignany hyperthermia) |
|
|
sumatriptan (Imitrex)
|
Triptan
Migraine abortive |
|
|
almotriptan (Axert)
|
Triptan
Migraine abortive |
|
|
zolmitriptan (Zomig)
|
Triptan
Migraine abortive |
|
|
naratriptan (Amerge
|
Triptan
Migraine abortive |
|
|
rizatriptan (Maxalt)
|
Triptan
Migraine abortive |
|
|
frovatriptan (Frova)
|
Triptan
Migraine abortive |
|
|
eletriptan (Relpax)
|
Triptan
Migraine abortive |
|
|
Ergotamine
|
Ergot
Migraine abortive |
|
|
Dihydroergotamine
|
Ergot
Migraine abortive |
|
|
Methergine (methylergonovine)
|
Ergot
Migraine abortive |
|
|
bromocriptine
|
Ergot
Migraine abortive |
|
|
LSD
|
Ergot
|
|
|
Fiorinal/Fioricet
|
Aspirin or acetaminophen, plus butalbital plus caffeine
Migraine abortive |
|
|
Treximet
|
sumatriptan + naproxen
Migraine abortive |
|
|
Propranolol
|
Nonselective Beta blocker
Migraine Prevention |
|
|
Verapamil
|
Ca Channel Blocker
Migraine Prevention |
|
|
Divalproex
|
GABA potentiation?
Migraine Prevention |
|
|
Topiramate
|
Migraine prevention
|
|
|
Adderall
|
Indirect-acting sympathomimetic
Amphetamine |
|
|
Dexedrine (dextroamphetamine)
|
Indirect-acting sympathomimetic
Amphetamine |
|
|
Desoxyn (methamphetamine)
|
Indirect-acting sympathomimetic
Amphetamine |
|
|
Vyvanse (lisdexamfetamine)
|
Indirect-acting sympathomimetic
Amphetamine |
|
|
Ritalin
|
Indirect-acting sympathomimetic
Methylphenidate |
|
|
Concerta
|
Indirect-acting sympathomimetic
Methylphenidate |
|
|
Focalin (dexmethylphenidate)
|
Indirect-acting sympathomimetic
Methylphenidate |
|
|
benzphetamine (Didrex)
|
Miscellaneous indirect-acting drug
|
|
|
diethylpropion
|
Miscellaneous indirect-acting drug
|
|
|
phendimetrazine
|
Miscellaneous indirect-acting drug
|
|
|
“Fen-phen”:
– fenfluramine (or dexfenfluramine) plus phentermine |
Miscellaneous indirect-acting drug
|
|
|
(Meridia (sibutramine))
|
Miscellaneous indirect-acting drug
|
|
|
Provigil (modafinil)
|
Miscellaneous indirect-acting drug
|
|
|
Nuvigil (armodafinil)
|
Miscellaneous indirect-acting drug
|
|
|
Ephedrine
|
Miscellaneous indirect-acting drug
|
|
|
Strattera (atomoxitene)
|
Miscellaneous indirect-acting drug
|
|
|
imipramine
– desipramine – clomipramin |
Tricyclic antidepressant
|
|
|
amitriptyline (Elavil)
– nortriptyline |
Tricyclic antidepressant
|
|
|
doxepin
|
Tricyclic antidepressant
|
|
|
protriptyline
|
Tricyclic antidepressant
|
|
|
trimipramine
|
Tricyclic antidepressant
|
|
|
maprotiline
|
Tricyclic antidepressant
|
|
|
amoxapine
|
Tricyclic antidepressant
|
|
|
fluvoxamine
|
Selective serotonin reuptake inhibitor
|
|
|
sertraline (Zoloft)
|
Selective serotonin reuptake inhibitor
|
|
|
citalopram (Celexa)
|
Selective serotonin reuptake inhibitor
|
|
|
paroxetine (Paxil)
|
Selective serotonin reuptake inhibitors
|
|
|
escitalopram (Lexapro)
|
Selective serotonin reuptake inhibitors
|
|
|
fluoxetine (Prozac)
|
Selective serotonin reuptake inhibitors
|
|
|
venlafaxine (Effexor)
|
Serotonin-Norepinephrine Reuptake Inhibitors
|
|
|
desvenlafaxine (Pristiq)
|
Serotonin-Norepinephrine Reuptake Inhibitors
|
|
|
duloxetine (Cymbalta)
|
Serotonin-Norepinephrine Reuptake Inhibitors
|
|
|
milnacipran (Savella)
|
Serotonin-Norepinephrine Reuptake Inhibitors
|
|
|
phenelzine (Nardil)
|
Monoamine oxidase inhibitors
|
|
|
tranylcypromine
|
Monoamine oxidase inhibitors
|
|
|
Bupropion (Wellbutrin)
|
Atypical antidepressant
|
|
|
Mirtazapine
|
Atypical antidepressant
|
|
|
Nefazodone
|
Atypical antidepressant
|
|
|
Trazodone
|
Atypical antidepressant
|
|
|
Lithium
|
Treatment of Mania
Blocks DA release |
|
|
chlorpromazine (Thorazine)
|
Traditional Antipsychotic
|
|
|
thioridazine (Mellaril)
|
Traditional Antipsychotic
|
|
|
fluphenazine (Prolixin)
|
Traditional Antipsychotic
|
|
|
perphenazine (Trilafon)
|
Traditional Antipsychotic
|
|
|
trifluoperazine
|
Traditional Antipsychotic
|
|
|
thiothixene (Navane)
|
Traditional Antipsychotic
|
|
|
haloperidol
|
Traditional Antipsychotic
|
|
|
molindone
|
Traditional Antipsychotic
|
|
|
loxapine
|
Traditional Antipsychotic
|
|
|
pimozide (Orap)
|
Traditional Antipsychotic
|
|
|
aripiprazole (Abilify)
|
“Atypical” Antipsychotics
|
|
|
clozapine (Clozaril)
|
“Atypical” Antipsychotics
|
|
|
olanzapine (Zyprexa)
|
“Atypical” Antipsychotics
|
|
|
quetiapine (Seroquel)
|
“Atypical” Antipsychotics
|
|
|
risperidone (Risperdal)
|
“Atypical” Antipsychotics
|
|
|
ziprasidone (Geodon)
|
“Atypical” Antipsychotics
|
|
|
paliperidone (Invega)
|
“Atypical” Antipsychotics
|
|
|
lurasidone (Latuda)
|
“Atypical” Antipsychotics
|
|
|
olanzapine + fluoxetine (Symbyax)
|
“Atypical” Antipsychotics
|
|
|
Levodopa
|
prodrug of DA
antiparkinsons |
|
|
Carbidopa
|
AAAD inhibitor
antiparkinsons |
|
|
Sinemet
|
carbidopa + levodopa
antiparkinsons |
|
|
Tolcapone
|
COMT inhibitor
antiparkinsons |
|
|
Entacapone
|
COMT inhibitor
antiparkinsons |
|
|
Bromocriptine
|
D2 receptor agonists (ergots)
antiparkinsons |
|
|
Pergolide
|
D2 receptor agonists (ergots)
antiparkinsons |
|
|
Ropinirole
|
D2 receptor agonists (ergots)
antiparkinsons |
|
|
Pramipexole
|
D2 receptor agonists (ergots)
antiparkinsons |
|
|
Apomorphine
|
D2 receptor agonists (ergots)
antiparkinsons |
|
|
Selegiline (eldepryl)
|
MAO-B inhibitor
antiparkinsons |
|
|
Rasagiline (azilect)
|
MAO-B inhibitor
antiparkinsons |
|
|
Benztropine
|
anticholinergic
antiparkinsons |
|
|
Trihexyphenidyl
|
anticholinergic
antiparkinsons |
|
|
Amatadine
|
Antiviral/ sympathomimetic like
antiparkinsons |
|
|
Tacrine (Cognex
|
Cholinesterase inhibitors
Anti ALZ |
|
|
Donepezil (Aricept)
|
Cholinesterase inhibitors
Anti ALZ |
|
|
Rivastigmine (Exelon)
|
Cholinesterase inhibitors
Anti ALZ |
|
|
Galantamine (Razadyne)
|
Cholinesterase inhibitors
Anti ALZ |
|
|
Memantine (namenda)
|
NMDA receptor blocker
Anti ALZ |
|
|
Riluzole (Rilutek)
|
NMDA receptor blocker
Anti ALZ |
|
|
Ceftriaxone
|
Cephalosporin
Anti ALZ |
|
|
Fludrocortisone (flurinef)
|
Mineralocorticoid receptor agonists
|
|
|
Cortisol/hydrocortisone
|
Glucocorticoid receptor agonists
|
|
|
Prednisone
|
Glucocorticoid receptor agonists
|
|
|
Prednisolone
|
Glucocorticoid receptor agonists
|
|
|
Cortisone
|
Glucocorticoid receptor agonists
|
|
|
Methylprednisolone
|
Glucocorticoid receptor agonists
|
|
|
Triamcinolone
|
Glucocorticoid receptor agonists
|
|
|
Betamethasone
|
Glucocorticoid receptor agonists
|
|
|
Dexmethasone
|
Glucocorticoid receptor agonists
|
|
|
CRF (Acthrel)
|
synthetic CRF to determine adrenal insufficiency
|
|
|
ACTH
|
synthetic ACTH to determine adrenal insufficiency
|
|
|
trilostane
|
Cortisol synthesis inhibitors (cushings disease)
|
|
|
aminoglutethimide
|
Cortisol synthesis inhibitors (cushings disease)
|
|
|
metyrapone
|
Cortisol synthesis inhibitors (cushings disease)
|
|
|
ketoconazole
|
Cortisol synthesis inhibitors (cushings disease)
|
|
|
Interferon-beta (Avonex, Rebif, Betaseron)
|
Disease Modifying Immunosuppressant
Multiple Sclerosis |
|
|
glatiramer acetate (Copaxone)
|
Disease Modifying Immunosuppressant
Multiple Sclerosis |
|
|
natalizumab (Tysabri)
|
Disease Modifying Immunosuppressant
Multiple Sclerosis |
|
|
dalfampridine (Ampyra)
|
Blocks K+ efflux from demyelinated segments to improve conduction
Multiple Sclerosis |
|
|
fingolimod (Gilenya)
|
Disease Modifying Immunosuppressant
Sphingosine phosphate (S1P1) receptor agonist (downregulation) Multiple Sclerosis |
|
|
mitoxantrone (novantrone)
|
Antineoplastic Agent
Secondary Progressive MS |
|
|
cyclosporine (sandimmune, restasis)
|
Immunosuppressant
|
|
|
tacrolimus (Prograf, Protopic)
|
Immunosuppressant
|
|
|
pimecrolimus (Elidel)
|
Immunosuppressant
calcineurin inhibitor |
|
|
sirolimus (Rapamune)
|
Immunosuppressant
mTOR inhibitor |
|
|
azothioprine (Imuran)
|
Immunosuppressant/ traditional DMARD/ IBD
purine synthesis inhibitor |
|
|
mycophenolate mofetil (Cellcept, Myfortic)
|
Immunosuppressant
|
|
|
daclizumab
|
Immunosuppressant
IL-2 receptor |
|
|
basiliximab
|
Immunosuppressant
IL-2 receptor |
|
|
muromonab-CD3
|
Immunosuppressant
|
|
|
methotrexate
|
Traditional DMARD
Dihydrofolate reductase inhibitor (inhibits purine synthesis) |
|
|
leflunomide (Arava)
|
Traditional DMARD
Pyrimidine synthesis inhibitor |
|
|
sulfasalazine
|
Traditional DMARD
+IBD |
|
|
hydroxyqloroquine (Plaquenil)
|
Traditional DMARD
IL-1 release inhibitor |
|
|
gold (auranofin, solganol)
|
Traditional DMARD
|
|
|
penicillamine
|
Traditional DMARD
|
|
|
azothioprine (Imuran)
|
Immunosuppressant, Traditional DMARD
|
|
|
cyclosporine
|
Immunosuppressant, Traditional DMARD
|
|
|
enbrel (etanercept)
|
TNFα Antagonist
Biological DMARD |
|
|
remicade (infliximab)
|
TNFα Antagonist
Biological DMARD |
|
|
Humira (adalmumab)
|
TNFα Antagonist
Biological DMARD |
|
|
cimzia (certolizumab)
|
TNFα Antagonist
Biological DMARD |
|
|
simponi (golimumab)
|
TNFα Antagonist
Biological DMARD |
|
|
kineret (Anakinra)
|
IL-1 Receptor Antagonist
biological DMARD |
|
|
actemra (tocilizumab)
|
Biological DMARD
IL-6 Receptor Antagonist |
|
|
orencia (abatacept)
|
Biological DMARD :Fusion Protein
Binds CD80 + CD86 on B-Cell (Block antigen presenting) |
|
|
clomiphene (clomid)
|
Estrogen/androgen Receptor Antagonist
prevents feedback inhibition Infertility |
|
|
menotropins
|
Exogenous Gonadotropins
(FSH + LH) Infertility |
|
|
gonadorelin
|
Synthetic GnRH
Infertility |
|
|
ganirelix
|
GnRH Antagonist
Given with exogenous FSH to ensure maturation of follicles before premature LH surge Infertility, cancer |
|
|
cetrorelix
|
GnRH Antagonist
Given with exogenous FSH to ensure maturation of follicles before premature LH surge Infertility, cancer |
|
|
Minipill
|
Progestin only
|
|
|
ethinyl estradiol
|
estrogen
|
|
|
mestranol
|
estrogen
|
|
|
norgestimate
|
progestin
|
|
|
medroxyprogesterone
|
progestin
|
|
|
norgestrel
|
progestin
|
|
|
levonorgestrel
– Plan B |
progestin
|
|
|
norethindrone
|
progestin
|
|
|
ethynodiol
|
progestin
|
|
|
desogestrel
|
progestin
|
|
|
drosperinone
|
progestin
|
|
|
testosterone (depo-testosterone, androderm, androgel)
|
androgen
hypogonadism, post menopause, male senescence |
|
|
danocrine (Danazol)
|
weak androgen receptor agonist
endometriosis |
|
|
fluoxymestrone (Halotestin)
|
Anabolic steroid
|
|
|
oxandrolone
|
Anabolic steroid
|
|
|
oxymetholone
|
Anabolic steroid
|
|
|
stanozolol (Winstrol)
|
Anabolic steroid
|
|
|
nandrolone (Deca Durabolin)
|
Anabolic steroid
|
|
|
Abarelix
|
GnRH receptor antagonist
prostate cancer |
|
|
leuprolide (Lupron)
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
nafarelin
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
goserelin
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
buserelin
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
histrelin
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
triptorelin
|
GnRH Receptor Agonist
prostate / breast cancer endometriosis precocious puberty |
|
|
finasteride (Propecia)
|
5-alpha reductase inhibitor
II > I anti-baldness |
|
|
finasteride (Proscar)
|
5-alpha reductase inhibitor
II > I BPH |
|
|
duasteride
|
5-alpha reductase inhibitor
nonselective anti-baldness, BPH |
|
|
flutamide (Eulexin)
|
Androgen Receptor Antagonist
prostate cancer |
|
|
bicalutamide (Lasodex)
|
Androgen Receptor Antagonist
prostate cancer |
|
|
nilutamide (Nilandron)
|
Androgen Receptor Antagonist
prostate cancer |
|
|
somatropin
|
Recombinant GH
|
|
|
somatrem
|
Recombinant GH
|
|
|
sermorelin
|
Synthetic GHRH
allows negative feedback when taking gonadotropins pituitary testing |
|
|
octreotide (Sandostatin)
|
Somatostatin-5 Agonist (SST-5 Agonist)
decreases the release of GH from pituitary acromegaly, GI bleeds (constriction) |
|
|
pegvisomant (Somavert)
|
Recombinant GH Antagonist
|
|
|
raloxifene
|
Anti-resorptive Drug
osteoporosis |
|
|
Alendronate (Fosamax)
|
Bisphosphonate
osteoporosis |
|
|
Risedronate (Actonel)
|
Bisphosphonate
osteoporosis |
|
|
Ibandronate (Boniva)
|
Bisphosphonate
osteoporosis |
|
|
miacalcitonin
|
Salmon Calcitonin
osteoporosis |
|
|
Teriparatide (Forteo)
|
Recombinant fragment of parathyroid hormone
Paradoxical effect: Increase osteoblast activity 2 year use only - cancer risk |
|
|
lispro (Humalog)
|
Rapid Acting Insulin
|
|
|
aspart (Novolog)
|
Rapid Acting Insulin
|
|
|
glulisine (Apidra)
|
Rapid Acting Insulin
|
|
|
Humulin R, Novolin R
|
Short Acting Regular Insulin
|
|
|
Humulin N, Novolin N
|
Protamine complexed intermediate acting insulin
|
|
|
glargine (Lantus)
|
Long Acting Insulin
|
|
|
detemir (Levemir)
|
Long Acting Insulin
|
|
|
pramlintide (Symlin)
|
Synthetic Amylin
Slows gastric emptying rate and absorption of glucose Decreases release of glucagon from pancreas |
|
|
pioglitazone (Actos)
|
Thiazolidinedione
PPAR Agonist Increase insulin sensitivity |
|
|
rosiglitazone (Avandia)
|
Thiazolidinedione
PPAR Agonist Increase insulin sensitivity |
|
|
acarbose (Precose)
|
α Glucosidase Inhibitor
Slows breakdown of starches to glucose in intestine to balance absorption |
|
|
miglitol (Glyset)
|
α Glucosidase Inhibitor
Slows breakdown of starches to glucose in intestine to balance absorption |
|
|
chlorpropamide
|
Secretagogue: Sulfonylurea
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
glyburide (Micronase)
|
Secretagogue: Sulfonylurea
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
glipizide (Glucotrol)
|
Secretagogue: Sulfonylurea
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
glimepiride (Amaryl)
|
Secretagogue: Sulfonylurea
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
repaglinide (Prandin)
|
Secretagogue: Meglitinide
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
natelinide (Starlix)
|
Secretagogue: Meglitinide
Block K+ channel mimicking ATP in beta cell to increase insulin secretion May block glucagon + glucose release from liver |
|
|
exenatide (Byetta)
|
GLP-1 Agonist
type 2 DM |
|
|
liraglutide (Victoza)
|
GLP-1 Agonist
type 2 DM |
|
|
sitagliptin (Januvia)
|
DPP-IV Inhibitor
prevents GLP-1 breakdown |
|
|
saxagliptin (Onglyza)
|
DPP-IV Inhibitor
prevents GLP-1 breakdown |
|
|
Sulfasalazine
|
aminosalicylate
IBD |
|
|
olsalazine (Dipentum)
|
2nd gen aminosalicylate
IBD |
|
|
balsalazide (Colazal)
|
2nd gen aminosalicylate
IBD |
|
|
Mesalamine
(Asacol, Pentasa, Rowasa, Canasa) |
5-aminosalicylate
IBD |
|
|
Budesonide (Entocort EC)
|
corticosteroid
IBD |
|
|
Remicade
|
immunosupressant for IBD
can also use cyclosporine, azathioprine, methotrexate |
|
|
metronidazole
|
antibiotic for IBD
|
|
|
ciprofloxacin
|
antibiotic for IBD
|
|
|
estradiol
(Estrace, Climara, Vivelle) |
Estrogen Receptor Agonists
|
|
|
estrone or estropipate (Ogen)
|
Estrogen Receptor Agonists
|
|
|
conjugated estrogens (Premarin)
|
Estrogen Receptor Agonists
|
|
|
esterified estrogens (Menest)
|
Estrogen Receptor Agonists
|
|
|
synthetic conjugated estrogens (Cenestin, Enjuvia)
|
Estrogen Receptor Agonists
|
|
|
estrogen
• Vagifem • Estring, Femring |
Estrogen Receptor Agonists
|
|
|
raloxifene (Evista)
|
Selective Estrogen Receptor Modulators SERM
|
|
|
tamoxifen (Nolvadex)
|
Selective Estrogen Receptor Modulators SERM
|
|
|
toremifene (Fareston)
|
Selective Estrogen Receptor Modulators SERM
|
|
|
Fulvestrant (Faslodex)
|
SERD: (down regulates estrogen receptor) (treatment of breast cancer post menopause)
|
|
|
Medroxyprogesterone acetate (Provera)
|
Progestin Receptor Agonists
HRT |
|
|
Norethindrone (Aygestin)
|
Progestin Receptor Agonists
HRT |
|
|
Prometrium
Crinone |
Progesterone
Progestin Receptor Agonists HRT |
|
|
• Prempro
• FemHRT • Climara Pro • Combipatch |
estrogen + progestin combos
HRT |
|
|
mifepristone (RU-486)
|
Progesterone receptor antagonist
Abortion |
|
|
HCG
|
(LH receptor agonist)
gonadotropin infertility |
|
|
calcium
|
(↓ parathyroid hormone: which ↑ osteoclasts)
antiresorptive |
|
|
Cholecalciferol D3
Ergocalciferol D2 |
vitamin D (↑ absorption of Ca from GIT: ↓ parathyroid hormone)
antiresortptive |
|
|
Calcitrol
|
vitamin D (↑ absorption of Ca from GIT: ↓ parathyroid hormone)
antiresorptive |
|
|
Levothyroxine
|
T4
Synthroid, Levoxyl, Levothroid, Unithroid |
|
|
Liothyronine
|
T3
Cytomel |
|
|
liotrix
|
T4+T3
Thyrolar |
|
|
armour thyroid
|
dessicated thyroid
|
|
|
propylthiouracil
|
Peroxidase inhibitor (antithyroid)
PTU |
|
|
Methimazole
|
Peroxidase inhibitor (antithyroid)
|
|
|
Thiocyanate
|
ionic symport inhibitor
antithyroid |
|
|
Perchlorate
|
ionic symport inhibitor
antithyroid |
|
|
Lugol's solution
|
Iodide (paradoxical ↓ expression of symporter) Goiter
|
|
|
SSKI
|
Iodide (paradoxical ↓ expression of symporter) Goiter
|
|
|
131I
|
kills thyroid cells DOC for hyperthyroid/ graves
|
|
|
Prochlorperazine
|
D2 receptor antagonists- antiemetic
(Compazine) |
|
|
trimethobenzamide
|
D2 receptor antagonists-antiemetic
(Tigan) |
|
|
promethazine
|
D2 receptor antagonists- antiemetic
(Phenergan) |
|
|
ondansetron
|
5‐HT3 receptor blockers- antiemetic
(Zofran) |
|
|
granisetron
|
5‐HT3 receptor blockers- antiemetic
(Kytril) |
|
|
dolasetron
|
5‐HT3 receptor blockers- antiemetic
(Anzemet) |
|
|
palonosetron
|
5‐HT3 receptor blockers- antiemetic
(Aloxi) |
|
|
metoclopramide
|
D2 blocker + 5-HT3 blocker- antiemetic
(Reglan) |
|
|
Cisapride
|
D2 blocker + 5-HT3 blocker- antiemetic
|
|
|
aprepitant/fosaprepitant
|
NK‐1 receptor antagonist- antiemetic
(Emend) |
|
|
dronabinol
|
CB‐1 receptor agonists- antiemetic
(Marinol) |
|
|
Nabilone
|
CB‐1 receptor agonists- antiemetic
(Cesamet) |
|
|
alosetron
|
d-IBS
(Lotronex) |
|
|
Dicyclomine
|
anti Ach for d-IBS
|
|
|
Amitriptyline
|
TCA for d-IBS
|
|
|
Immodium
|
peripheral Mu agonist for d-IBS
|
|
|
Lomotil
|
peripheral Mu agonist for d-IBS
|
|
|
lubiprostone
|
c-IBS
(Amitiza) |
|
|
misoprostol
|
PGE2 agonist
antiulcer (Cytotec) |
|
|
Sucralfate
|
Artificial mucus
antiulcer |
|
|
cimetidine
|
H2 receptor antagonists
antiulcer (Tagamet) |
|
|
ranitidine
|
H2 receptor antagonists
antiulcer (Zantac) |
|
|
nizatidine
|
H2 receptor antagonists
antiulcer (Axid) |
|
|
famotidine
|
H2 receptor antagonists
antiulcer (Pepcid) |
|
|
omeprazole
|
Proton pump inhibitors
(Prilosec/Zegerid) |
|
|
esomeprazole
|
Proton pump inhibitors
(Nexium) |
|
|
lansoprazole
|
Proton pump inhibitors
(Prevacid) |
|
|
dexlansoprazole
|
Proton pump inhibitors
(Kapidex) |
|
|
rabeprazole
|
Proton pump inhibitors
(Aciphex) |
|
|
pantoprazole
|
Proton pump inhibitors
(Protonix) |
|
|
Xolair
|
anti- IgE
(omalizumab) |
|
|
Cromolyn
|
Mast cell stabilizer
|
|
|
Nedocromil
|
Mast cell stabilizer
|
|
|
diphenhydramine
|
1st gen H1 blocker
(Benadryl) |
|
|
clemastine
|
1st gen H1 blocker
(Tavist) |
|
|
dimenhydrinate
|
1st gen H1 blocker
(Dramamine) |
|
|
chlorpheniramine
|
1st gen H1 blocker
(ChlorTrimeton) |
|
|
brompheniramine
|
1st gen H1 blocker
|
|
|
hydroxyzine
|
1st gen H1 blocker
(Atarax/Vistaril) |
|
|
cyclizine
|
1st gen H1 blocker
|
|
|
meclizine
|
1st gen H1 blocker
(Antivert) |
|
|
promethazine
|
1st gen H1 blocker
(Phenergan) |
|
|
cyproheptadine
|
1st gen H1 blocker
(Periactin) |
|
|
doxepin
|
1st gen H1 blocker
|
|
|
loratadine
|
2nd gen H1 blocker
(Claritin) |
|
|
desloratadine
|
2nd gen H1 blocker
(Clarinex) |
|
|
cetirizine
|
2nd gen H1 blocker
(Zyrtec) |
|
|
azelastine
|
2nd gen H1 blocker
(Astelin) |
|
|
fexofenadine
|
2nd gen H1 blocker
(Allegra) |
|
|
Epinephrine
|
for emergency histamine rxns
Epi pen |
|
|
Mechlorethamine
|
(Antineoplastic)
Alkylating agents Nitrogen mustards (Mustargen) |
|
|
Chlorambucil
|
(Antineoplastic)
Alkylating agents Nitrogen mustards (Leukeran) |
|
|
Melphalan
|
(Antineoplastic)
Alkylating agents Nitrogen mustards (Alkeran) |
|
|
Cyclophosphamide
|
(Antineoplastic)
Alkylating agents Nitrogen mustards (Cytoxan) |
|
|
Ifosfamide
|
(Antineoplastic)
Alkylating agents Nitrogen mustards (Ifex) |
|
|
Carmustine
|
(Antineoplastic)
Alkylating agents Nitrosoureas (BCNU) |
|
|
Lomustine
|
(Antineoplastic)
Alkylating agents Nitrosoureas (CCNU) |
|
|
Dacarbazine
|
(Antineoplastic)
Alkylating agents Triazines (DTIC) |
|
|
Procarbazine
|
(Antineoplastic)
Alkylating agents Triazines |
|
|
Temozolomide
|
(Antineoplastic)
Alkylating agents Triazines |
|
|
Cisplatin
|
Antineoplastic
Platium coordination complex |
|
|
Carboplatin
|
Antineoplastic
Platium coordination complex |
|
|
Oxaliplatin
|
Antineoplastic
Platium coordination complex |
|
|
Methotrexate
|
Antineoplastic
Antimetabolites Antifolate (MTX) |
|
|
Permetrexed
|
Antineoplastic
Antimetabolites Antifolate |
|
|
sodium 2-mercaptoethane sulfonate
|
(Mesna)
inactivate toxic metabolite Acrolein that is formed by alkylating agents (reverse bladder toxicity) |
|
|
Gliadel
|
Implantable wafer of Carmustine (BCNU)
|
|
|
Amifostine
|
(prodrug antidote to inactivate acrolein)
for nephrotox with platinum complex |
|
|
folinic acid
|
(Leucovorin)
Reversal of high dose methotrexate toxicity |
|
|
Filgrastim/Pegfilgrastim
|
promotes bone marrow growth
|
|
|
Colonly stimulating factor
|
Promotes bone marrow growth
|
|
|
6-mercaptopurine
|
antineoplastic
purine metabolism inhibitor 6-MP |
|
|
Thioguanine
|
antineoplastic
purine metabolism inhibitor (TG) |
|
|
Fludarabine
|
antineoplastic
Purine analogs that incorporate into DNA |
|
|
Cladribine
|
antineoplastic
Purine analogs that incorporate into DNA |
|
|
5-Fluorouracil
|
antineoplastic
Inhibitors of Thymidylate Synthase (TS) (5-FU) IV drug |
|
|
Capecitabine
|
antineoplastic
Inhibitors of Thymidylate Synthase (TS) (Prodrug of 5-FU) PO drug |
|
|
Cytarabine
|
antineoplastic
Inhibitors of Thymidylate Synthase (TS) (Ara-C)(arabinose-C) |
|
|
Gemcitabine
|
antineoplastic
Inhibitors of Thymidylate Synthase (TS) |
|
|
Azacitidine
|
antineoplastic
methyltransferase inhibitors |
|
|
Decitabine
|
antineoplastic
methyltransferase inhibitors |
|
|
Hydroxyurea
|
antineoplastic
|
|
|
Vincristine
|
antineoplastic
Antimitotic: vinca alkaloids |
|
|
Vinblastine
|
antineoplastic
Antimitotic: vinca alkaloids |
|
|
Vinorelbine
|
antineoplastic
Antimitotic: vinca alkaloids |
|
|
Paclitaxel
|
antineoplastic
Antimitotic: Taxanes |
|
|
Docetaxel
|
antineoplastic
Antimitotic: Taxanes |
|
|
Nab-Paclitaxel
|
antineoplastic
Antimitotic: Taxanes (Abraxane) |
|
|
Cabazitaxel
|
antineoplastic
Antimitotic: Taxanes |
|
|
Ixabepilone
|
antineoplastic
Antimitotic: Epothilones |
|
|
Irinotecan
|
antineoplastic
Topoisomerase I inhibitor Camptothecans (CPT-11) |
|
|
Topotecan
|
antineoplastic
Topoisomerase I inhibitor Camptothecans |
|
|
Daunorubicin
|
antineoplastic
Topoisomerase II inhibitors anthracyclines |
|
|
Doxorubicin
|
antineoplastic
Topoisomerase II inhibitors anthracyclines |
|
|
Epirubicin
|
antineoplastic
Topoisomerase II inhibitors anthracyclines |
|
|
Idarubicin
|
antineoplastic
Topoisomerase II inhibitors anthracyclines |
|
|
Mitoxantrone
|
antineoplastic
Topoisomerase II inhibitors anthracyclines |
|
|
Etoposide
|
antineoplastic
Topoisomerase II inhibitors epipodophyllotoxins (VP-16) |
|
|
Teniposide
|
antineoplastic
Topoisomerase II inhibitors epipodophyllotoxins (VN-26) |
|
|
Bleomycin
|
antineoplastic
DNA binding and strand breaking admin with anthracyclines |
|
|
Aminoglutethimide
|
antineoplastic
Aromatase inhibitors 1st generation |
|
|
Anastrozole
|
antineoplastic
Aromatase inhibitors 3rd generation |
|
|
Letrozole
|
antineoplastic
Aromatase inhibitors 3rd generation |
|
|
Exemestane
|
antineoplastic
Aromatase inhibitors 3rd generation |
|
|
Bortezomib
|
antineoplastic
Protease inhibitor |
|
|
Thalidomide
|
antineoplastic
TNF-α inhibitors |
|
|
Lenalidomide
|
antineoplastic
TNF-α inhibitors |
|
|
L-Asparaginase
|
antineoplastic
|
|
|
Ipilimumab
|
antineoplastic
immunotherapy CTLA4 inhibitor |
|
|
Sipuleucel-T
|
antineoplastic
immunotherapy Therapeutic vaccine |
|
|
Rituximab
|
Tumor specific MABs
CD20 |
|
|
I131 Tositumomab
|
Tumor specific MABs
CD20 |
|
|
Y90 Ibritumomab
|
Tumor specific MABs
CD20 |
|
|
Alemtuzumab
|
Tumor specific MABs
CD52 |
|
|
Erlotinib
|
Growth factor antagonists
Small Molecule Inhibitors of EGFR |
|
|
Gefitinib
|
Growth factor antagonists
Small Molecule Inhibitors of EGFR |
|
|
Lapatinib (EGFR and HER2)
|
Growth factor antagonists
Small Molecule Inhibitors of EGFR and HER2 |
|
|
Bevacizumab (Avastin)
|
Anti angiogenesis
MAB against VEGF |
|
|
Sorafenib
|
Anti angiogenesis
TKI (SM inhibitors of VEGF TKs) |
|
|
Sunitinib
|
Anti angiogenesis
TKI (SM inhibitors of VEGF TKs) Pazopanib |
|
|
Pazopanib
|
Anti angiogenesis
TKI (SM inhibitors of VEGF TKs) |
|
|
Imatinib
|
TKI specific for BCR-ABL
|
|
|
Dasatinib
|
TKI specific for BCR-ABL
2nd gen |
|
|
Nilotinib
|
TKI specific for BCR-ABL
2nd gen |
|
|
Cetuximab
|
Human epidermal receptor Antibodies
EGFR |
|
|
Panitumumab
|
Human epidermal receptor Antibodies
EGFR |
|
|
Trastuzumab
|
Human epidermal receptor Antibodies
HER-2 |
|
|
Bevacizumab
|
Human epidermal receptor Antibodies
VEGF |
|
|
Temsiorlimus
|
mTOR inhibitors
|
|
|
Everolimus
|
mTOR inhibitors
|
|
|
Benzocaine
|
Local Anesthetics
Ester linked |
|
|
Procaine (Novocain)
|
Local Anesthetics
Ester linked |
|
|
Tetracaine
|
Local Anesthetics
Ester linked |
|
|
Topical Cocaine
|
Local Anesthetics
Ester linked |
|
|
Chloroprocaine
|
Local Anesthetics
Ester linked |
|
|
Lidocaine
|
Local Anesthetics
Amide linked |
|
|
Dibucaine
|
Local Anesthetics
Amide linked |
|
|
Mepivacaine
|
Local Anesthetics
Amide linked |
|
|
Bupivacaine
|
Local Anesthetics
Amide linked |
|
|
Prilocaine
|
Local Anesthetics
Amide linked |
|
|
Ropivacaine
|
Local Anesthetics
Amide linked |
|
|
Articaine
|
Local Anesthetics
Amide linked |
|
|
EMLA
|
(Lidocaine + procaine)
Eutectic mixture of local anesthetics |
|
|
Epinephrine use in local anesthetics?
|
Vasoconstriction
increase duration |
