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4 Cards in this Set
- Front
- Back
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(P) SERTALINE
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SSRI (Selective Serotonin Reuptake Inhibitor)
4: Depression OCD Anxiety - Panic dis PTSD MECH: Inhibits Serotonin reuptake (leaves more available) - partially limits NE & Dop reuptake CONTRAS: low Liver func. ADVERSES: HeadA, Fatigue / insomnia SUICIDE (in kids) GI probs, Sex dysfunc ** Max effect not reached for several weeks** **NOT given with other highly protien bound drugs** ***DO NOT ABRUPTLY STOP** **give with food** |
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(P) NORTRIPTYLINE
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TRICYCLIC ANTIDEPRESSANT
4: Depression Chronic Pain MECH: blocks reuptake of NE = more at postsynaptic effector sites CONTRAS: CV dis ADVERSES: drowsiness / xerostomia Bone marrow depression hypOtension ARRHYTHMIAS (changes atrioventricular conduction) constipation **not 4 kids / lower dose in elderly** **Need therapeutic plasma level - go for at least 3 months** **give at BEDTIME (or 2x/day)** **takes a few weeks 4 full effect** |
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(P) PHENELZINE
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MOAI (Monoamine oxidase inhibitor)
4: Depression (unresponsive to other Txs) MECH: up DOP, NE & Serotonin in snyapses CONTRAS: heart failure bad liver/kidney ADVERSES: anti-cholinergic effects (anti-"fight or flight") blurred vision / restlessness orthostatic hypOtens Hypertensive Crisis AGRANULOCYTOSIS ** keep platelet MAO enzyme activity btwn 85-95%** **Avoid: tyramine foods & OTC w/ dextromethorphan** ** med effects may take several weeks - DON'T STOP ABRUPTLY** **Give less to elderly - NOT 4 KIDS** |
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(P) LITHIUM CARBONATE
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MOOD STABILIZER
4: bipolar dis (especially manic episodes) MECH: competes w/ Ca, K, Na - alters Na Xport in nerves & muscles CONTRAS: severe renal or CV dis ADVERSES: blurred vis / drowsy / confusion polydipsia L.I. TOXICITY tremor GI upset **monitor serum LI levels** **preg cat D** **limit caffeine & alcohol (limits responsiveness to drug)** ** Japanese & elderly need lower doses** ** watch for dehydration (toxicity more likely)** |
