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17 Cards in this Set

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What is Pharmacokinetics?
action or effect of body on drug(what the body does on the drugs as opposed to what the drug does on the body)
relates to absorption,distribution,metabolism and excretion in the body(ADME)
What is Pharmacodynamics?
action or effect of drug on body
-how drugs interact with their targets
Give definitions of a “drug”
Any substance that brings about a change in biologic function through its chemical actions


A molecule that interacts with specific molecular components (i.e. receptor) of an organism to cause biochemical and physiologic changes


Any substance received by a biological system that is not received for normal nutritive purposes
Drug target
Tissue element with which drugs interact to produce a change in a biological system
T or F.A drug may stabilize a receptor conformation that either augments or diminishes a cellular effect.
True.i.e.Drugs modulate intrinsic physiological functions
Agonist
Bind receptors to mimic stimulatory effects of endogenous signaling molecules
Antagonist
Bind receptors to prevent binding of (and activation by) agonists; exhibit no activity
Give examples of some drugs which do not interact with specific targets.
Antacids-binds to protons
Osmotic agent
List the types of drug targets.
1)Ion channels(Ligand-gated
Voltage-gated
2nd messenger-gated)
2)G protein-coupled receptors (GPCRs), or 7 transmembrane receptors (7TMRs)
3)Transmembrane receptors with enzymatic cytosolic domains

Kinases

Phosphatases

Guanylyl Cyclases)
4)Receptors with enzymatic activity (e.gHER2 Receptors)
factors affecting drug-receptor interaction
Receptor(e.g a.acid conformation)
Drug(structure-activity relationship)
Environment(e.g PH)
most rapid receptor system?
Ion channels
True or False.Almost all receptor sytems contain enzymatic activity.
True
Discuss chemical factors(Chemical force/bond) contributing to drug-receptor interaction
Hydrophobic
Van der Waals
Hydrogen bonding
Ionic bonding
Covalent bonding
Characterstics of Ion channel drug receptor systems
classified as ligand gated(depending on the ligand)
Voltage gated(depending on the voltage)
or Second messenger gated
-May undergo cycle of activation, open, closed, channel inactivation (refractory period in which channel cannot be activated)
Characterstics of GPCR drug receptor systems
2nd messenger generation to amplify signal
Can have various allosteric sites for ligand binding
drug target that would take the longest to produce an effect
Steroids
example of a non protein drug target
DNA's