Pharmacokinetics (Movement Of Drug)

Front 1

Absorption (affected by 3 things)

Back 1

- Route
- The absorbing surface
- Solubility (the ability of the drug to be absorbed)

Front 2

Routes of drug administration (enteral)

Back 2

Enteral; "swallowed;" absorbed in the gut/stomach and intestines
- Intestines
- Oral
- Nasogastric
- Rectal

Front 3

Routes of drug administration (parenteral)

Back 3

Parenteral; injected by a needle
- IV
- SQ
- IM
- ID
- Intrapleural
- Intrathecal; introduced into or occurring in the space under the arachnoid membrane of the brain or spinal cord

Front 4

Routes of administration (percutaneous)

Back 4

Percutaneous; topical (coating an area)
- TD
- Ocular (eyes)
- Intrarespiratory
- Intravaginal
- Intrauterine
- Intranasal
- Otic (ear)

Front 5

The absorbing surface (blood flow)

Back 5

- Blood flow
- If decrease blood flow to the area, decreased drug absorption

Front 6

The absorbing surface (size)

Back 6

- Size
- The larger the size of the surface, the faster absorption of drug
- For example: large intestines absorb drugs fast because the large intestines cover a large area

Front 7

The absorbing surface (motility)

Back 7

- Motility
- The motility of the absorbing surface affects the amount of drug being absorbed
- For example: the GI tract

Front 8

Solubility of the drug (water soluble)

Back 8

- Water soluble
- hydrophilic= polarized; ionized (Ionization (or ionisation, see American and British English spelling differences) is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons. Ionization, often, results from the interaction of an atom or a molecule with an ionizing particle, including charged particles with sufficient energies and energetic photons.

Front 9

Affecting solubility (the ability of the drug to be absorbed)
- pH
- weak acid drug in acid media

Back 9

- Weak acid drug in an acid media
- Non-ionized (fat soluble)= better absorption

Front 10

Affecting solubility (the ability of the drug to be absorbed)
- pH
- weak acid drug in a basic media

Back 10

- Weak acid drug in a basic media
- Ionized (water soluble)= harder to absorb

Front 11

Affecting solubility (the ability of the drug to be absorbed)
- pH
- weak basic drug in an acid media

Back 11

- Weak basic drug in an acid media
- Ionized

Front 12

Affecting solubility (the ability of the drug to be absorbed)
- pH
- weak basic drug in a basic media

Back 12

- Weak basic drug in a basic media
- non-ionized

Front 13

Drug preparation (ointment)

Back 13

- Ointment; greasy; # 1

Front 14

Drug preparation (cream)

Back 14

- Cream; 1/2 way in between an ointment and a lotion; #2

Front 15

Drug preparation (lotion)

Back 15

- Lotion; non-greasy; water-based; # 3