Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
Highly protien bound drugs |
Warfarin Frusemide Diazepam Indomethacin Tolbutamide Clofibrate Salicylates Phenytoin Sulfonamides Phenylbutazone |
|
|
Drugs that bind to tissue |
Thiopentone sodium, benzodiazepines |
|
|
Drug that binds to muscles |
Emetine |
|
|
Drug that binds to bone |
Tetracyclines, lead. |
|
|
Drugs that bind to retina |
Chloroquine |
|
|
Drugs that bind to Thyroid |
Iodine |
|
|
Drugs with small volume of distribution |
Aspirin Aminoglyosides Phenylbutazone |
|
|
Drugs with large volume of distribution |
Pethidine Chloroquine |
|
|
Active drug to inactive metabolite |
Phenobarbitone to hydroxy phenobarbitone Phenytoin to hydroxy phenytoin |
|
|
Active drug to active metabolite |
Primidone to phenobarbitone Digitoxin to Digoxin Diazepam to Oxazepam Allopurinol to Alloxanthine |
|
|
Inactive drug to active metabolite |
Levodopa to Dopamine Prednisone to prednisolone Enalapril to Enalaprilat Bacampicillin to Ampicillin |
|
|
Microsomal enzymes important for oxidation reduction |
NADPH cytochrome P450 reductase Hemoprotein - Cytochrome P450 (CYP/P450) |
|
|
Drugs that undergo oxidation |
Phenytoin, Diazepam, Ibuprofen, Amphetamine, Chlorpromazine, Dapsone |
|
|
Drugs that undergo Hydroxylation |
Salicylic acid to gentisic acid Phenytoin to hydroxy phenytoin |
|
|
Drugs that undergo Dealkylation |
Imipramine to desmethylimipramine Codeine to morphine |
|
|
Drugs that undergo sulfoxide formation |
Cimetidine to cimetidine sulfoxide |
|
|
Drugs that undergo Deamination |
Amphetamine to Benzylmethyketone |
|
|
Drugs that undergo reduction |
Chloramphenicol to arylamine - nitro reduction Cortisone to hydrocortisone - keto reduction Halothane Disulfiram and nitrates are reduced by non microsomal enzymes |
|
|
Drugs that undergo hydrolysis |
Procaine, Atropine, Pethidine, Neostigmine, Enalapril |
|
|
Drugs that undergo Glucuronide conjugation |
Chloramphenicol, Morphine, Diazepam, Aspirin |
|
|
Drugs that undergo acetylation |
Sulfonamides, Isoniazid |
|
|
Drugs that undergo methylation |
Adrenaline, noradrenaline, dopamine, histamine |
|
|
Drugs that undergo Glutathione conjugation |
Paracetamol |
|
|
Drugs that undergo Sulphate conjunction |
Paracetamol, Steroids |
|
|
Drugs that undergo Amino acid conjunction |
Salicylic acid, Benzoic acid |
|
|
Glycine conjunction |
Salicylates |
|
|
Enzyme inducers |
Phenobarbitone, Rifampicin, Alcohol, Cigarette smoke, DDT, Griseofulvin, Carbamazepine, Phenytoin |
|
|
Enzyme inhibitors |
Chloramphenicol, Erythromycin, Ketoconazole, Cimetidine, Ciprofloxacin Verapamil |
|
|
Suicide inhibitors |
Selegiline, Ticlopidine, Clopidogrel Prophylthiouracil |
|
|
Nonmicrosomal enzyme inhibitors |
Allopurinol inhibits xanthine oxidase NSAIDs inhibt cyclo-oxygenase Theophylline inhibits phosphodiesterase Disulfiram inhibits aldehyde dehydrogenase Selegiline inhibits MAO-B |
