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153 Cards in this Set
- Front
- Back
Diethylpropion HCl
|
Stimulant
Appetite Suppressant |
|
Fenfluramine
|
Appetite Suppressant
No longer used - HEART PROBLEMS |
|
Ephedra
|
Stimulant
Appetite Suppressant |
|
Synephrine
aka? |
Stimulant - Appetite Suppressant
Bitter Orange - current fad |
|
Cotazyme
|
Pancreatic supplement
Containes Pancreatic enzymes for those deficient in such |
|
Decholine
|
Bile salt to ^ Bile flow from GB
|
|
Name 3 non-food appetite stimulents?
Used to treat? |
1)Thyroid Hormone
2)Insulin 3)Alkaloids Anorexia Nervosa |
|
Chenodeoxycholate (Chendiol)
|
Used to treat GALLSTONES
1)Inhibits HMG-CoA reductase - inhibiting cholesterol synthesis 2) Inhibits cholesterol conversion to bile acid 3)Dissolves gallstones -Ultimately reduces cholesterol saturation of bile seen in gallstone patients |
|
Ursodeoxycholate
|
Gallstone Txmt
Alters structure of cholesterol bile complex solid stones -> liquid crystal stones Increases Bile flow "The bear changes forms!' Urso = bear |
|
Monooctanoin
|
Dissolves gallstones
pushed up tube |
|
Sodium Bicarbonate
|
Antacid
CONTRA: Heart Dz & Low Na diet; Renal failure |
|
Calcium Carbonate
|
Antacid
SE: Nighttime Acid Rebound - b/c buildup of Ca; CONSTIPATION |
|
Magnesium Hydroxide
|
Antacid
SE: DIARRHEA |
|
Aluminum Hydroxide
|
Antacid
SLOW ONSET; LONG DURATION SE: CONSTIPATION |
|
Sucralfate
|
Mucosal Protecting Agent
REQUIRES ACID for activation! Never give with H2 blocker!! |
|
Carbenoxyolone
|
Mucosal Protecting Agent
SE: Na/FLUID retention ALDOSTERONE-LIKE side effects |
|
Misoprostol
|
Mucosal Protecting Agent; PROSTAGLANDIN
"Me-so Muco-sal Prostaglandin" ^ Bicarb secretion in mucous cells v of HCl release |
|
Cimetidine
|
H2 Blocker
Prevents increase in cAMP and Ca levels needed for acdtivation of H/K pump SE: Antiadrogen effects - Gynecomastia & Low sperm count IMPAIRS HEPATIC MET of DRUGS - NUMEROUS DRUG INTERACTIONS |
|
Side effect for most H2 Blockers?
|
Antiadrogen effects - Gynecomastia & Low sperm count
|
|
Ranitidine
|
H2 Blocker
Prevents increase in cAMP and Ca levels needed for acdtivation of H/K pump -more potant than Cimetidine SE: Antiadrogen effects - Gynecomastia & Low sperm count |
|
Famotidine
|
H2 Blocker
Prevents increase in cAMP and Ca levels needed for acdtivation of H/K pump SE: Antiadrogen effects - Gynecomastia & Low sperm count |
|
Nizatidine
|
H2 Blocker
Prevents increase in cAMP and Ca levels needed for acdtivation of H/K pump SE: Antiadrogen effects - Gynecomastia & Low sperm count |
|
Pirenzapine
|
Anti-muscarinic used for Gastic Acid overproduation
Prevents Ca entry into cells, v Acid |
|
Eradiacation of H pylor may induce?
|
INTESTINAL Cancer
|
|
Omeprazole
|
PPI
NEEDS ACID FOR ACTIVATION - DONT GIVE WITH H2 BLOCKER (Cimetidine/Ranitidine) SE: Hypergastremia -> ^ chances for gastric cancer |
|
Dimenhydrinate
|
"Dimen & Diphen hydras"
Antiemetic: H1 Blocker Prevents N/V WITH MOTION SICKNESS SE: Antimuscarinic effects - drowsiness, dry mouth, v gut motility etc |
|
Diphenhydramine
|
"Dimen & Diphen hydras"
Antiemetic: H1 Blocker Prevents N/V WITH MOTION SICKNESS SE: Antimuscarinic effects - drowsiness, dry mouth, v gut motility etc |
|
Meclizine
|
Antiemetic: H1 Blocker
SLOWER ONSET "Who wants to (not) throw up?! ME METO(o)!!) ME = Meclize METO = Metoclopramide Prevents N/V WITH MOTION SICKNESS SE: Antimuscarinic effects - drowsiness, dry mouth, |
|
Metoclopramide
|
Antiemetic - D2 BLOCKER
does NOT control MOTION SICKNESS also used in migraine & anticancer therapy ^ esophageal sphincter pressue & v pyloric sphincter pressue SE: Parkinsoniamism *^ GI motility do to Ach sensitization |
|
Bismuth Subsalicylate
|
Anti- diarrhea: adsorbent
Soaks up water in GI Tract SE: TINNITIUS |
|
Ipecac
|
Emetic
Stimualtes CTZ SE: Cardiotoxicity |
|
Apomorphine
|
Emetic
IV ONLY EMERGENCY/HOSPITAL use only SE: RESPIRATORY DEPRESSION *antidote is Naloxone "Morphine only given in hospitals! now go throw up and be (resp) depressed!" |
|
Mehyl Cellulose
|
Laxative
Bulk-forming |
|
Paraffin
|
Laxative
Stool Softener SE: Pneumonia Also Silicones = laxative - stool softener |
|
Phenolpthalein
|
Laxitive
Sitmulant SE: mucosal irritant: CARCINOGEN w/ chronic use |
|
Docusate
|
Laxative
Stool Softener |
|
Loperamide
|
NON ADDDICTIVE OPIATE treatment of diarrhea
(doesnt cross BBB) |
|
Amphotericin B
|
Antifungal: Polyene
IV only M: binds fungal membrane & creates a PORE SE: Infusion toxitcity, NEPHROTOXICITY |
|
Nystatin
|
Antifungal: Polyene
PO, Topical only M: binds fungal membrane & creates a PORE SE: Infusion toxitcity, NEPHROTOXICITY |
|
Ketoconazole
|
Antifungal: Azole
*fungiSTATIC M: Inbitits converstion of lanosterol to ergosterol -> membrane instability SE: Rash |
|
Fluconazole
|
Antifungal: Azole
*fungiSTATIC LONG DURATION -> 1x per day M: Inbitits converstion of lanosterol to ergosterol -> membrane instability CNS PENTRATION! : MENINGITIS MOST POPULAR SYSTEMATIC FUNGUS SE: None! Dose Adjustment: Only Azole renally exreted |
|
Voriconazazole
|
Antifungal: Azole
*fungiSTATIC LONG DURATION -> 1x per day M: Inbitits converstion of lanosterol to ergosterol -> membrane instability CNS PENTRATION! : MENINGITIS SE: VISUAL Disturbances, rash Apergillus - 1st line |
|
Posaconazole
|
Antifungal: Azole
*fungiSTATIC LONG DURATION -> 1x per day M: Inbitits converstion of lanosterol to ergosterol -> membrane instability Broadest specturm oral agent SE: Rash Zygomycetes - only reliabel frug for |
|
Echinocandins are? Examples?
Kills what species? How? |
Antifungals: "-fungin"
Caspofungin Anidulafungin Micafungin Prevent syn of B-glucan -> Disupttion of CELL WALL syn fungiSTATIC to Aspergillus fungiCIDAL to Candida |
|
Mebendazole
|
Anti-Helminth: Benzimidazole
Ineffective against Strongyloides & Hydatid disease (Echinococcosis) M: Inhibition of glucose uptake |
|
Albendazole
|
Anti-Helminth: Benzimidazole
First line for cestodes (tapeworms/flatworms) M: Degeneration fo intestines & tegument of worms |
|
Thiabendazole
|
Anti-Helminth: Benzimidazole
First line against Stongyloides M: Inhibits parasite FUMARATE REDUCTASE (in TCA cycle |
|
Ivermectin
|
Anti-Helminth: Averimectin
First line for Nematodes ONLY (b/c only Nematodes have GABA receptors) M: Induces release and binding of GABA poststynaptically at NMJ -> Paralysis "i ver GABA" = "I see GABA" in spanish |
|
Niclosamide
|
Anti-Helminth
CESTODES ONLY "Tapeworm wrapped around a nickel" M; inhibits glucose & oxygen uptake SE: NONE |
|
Praziquantel
|
Anti-Helminth: Antischistosomal
M: SYNERGISM b/w immune system & drug to kill worm SE: NONE |
|
Metrifonate
|
Anti-Helminth: Antischistosomal
M: AChase Inhibitor SE: bronchospasm |
|
Niridazole
|
Anti-Helminth: Antischistosomal
M: Accelerates glycogen utilization/depletion SE: Muscle weakness, Immunosuppression, CNS disurbnaces "Negro (Niridazole) has 1)AIDS (immunosuppressed) 2)is DUMB (CNS disturbnaces) 3)is WEAK (muscle weakness)" |
|
Oxamniquine
|
Anti-Helminth: Antischistosomal
M: Unknown; potentially inhibits protein and nucleic acid syn |
|
Paromomycin
|
Aminoglcoside Antibacterial useful as Anti-Protozoal agent
|
|
Metronidazole
|
Nitroimidazole
Used for Anaerobbes, H pylori, Protozoa M: poisons intracellular metabolism, ^ intracellular reduction of free radical production Clinically: -C. DIFFICILE COLITITS -H Pylori Gastro-Duodenal Disease -Bacterial vaginosis -Trichomonas Vaginitis |
|
Mechlorethamine
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Chlorambucil
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
*Cyclophosphamide
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity, HEMORRHAGIC CYSTITIS, ^ risk of BLADDER CANCER |
|
Mephlalam
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Thiotoepa
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Busulfan
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Decarbazine
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Carmustine
|
Anti-cancer: Alkylating Agent
U: Brain M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity |
|
Lomustine
|
Anti-cancer: Alkylating Agent
U: Leukemia M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: Brain, lympohoma |
|
Streptozocin
|
Anti-cancer: Alkylating Agent
U: Islet Cell Carcinoma (Pancrease) M: Alkylates DNA -> cross-linking of baes -> abnormal base paring -> STRAND BREAKAGE SE: myelotoxicity "STrEPped on my pancreas!" |
|
Cisplatin
|
Anti-cancer: Non-alkylating Crosslinking
M: NO ALKYLATION, crosslinking DNA -> abnormal base paring -> STRAND BREAKAGE SE: NEPHROTOXICITY |
|
Carboplatin
|
Anti-cancer: Non-alkylating Crosslinking
M: NO ALKYLATION, crosslinking DNA -> abnormal base paring -> STRAND BREAKAGE SE: MYELOSUPPRESSION |
|
Methotrexate
|
Anti-cancer: Antimetabolite
M: FOLATE analog: inhibition of pyrimidine AND purine syn prodrug of Mercaptopurine |
|
Mercaptopurine
|
Anti-cancer: Antimetabolite
M: ADENINE analog: inhibits de novo syn of purines from prodrug Methotraxate |
|
5-Flurouracil
|
Anti-cancer: Antimetabolite
Also ANTIFUNGAL for CRYPTOCOCCUS & CANDIDA Solid Cancer Txmt Thymidine/Uracil analog CONTRA: *DPD deficiency -must be monitored for toxicity |
|
Cytarabine
|
Anti-cancer: Antimetabolite
M: Cytidine analog |
|
Fludarabine
|
Anti-cancer: Antimetabolite
PURINE analog -> inhibit DNA synthesis |
|
Gemcitabine
|
Anti-cancer: Antimetabolite
PYRIMIDINE analog |
|
Imantinib
|
aka Gleevec
Anticancer tyrosine kinase inhibitor CML Txmt (ABL gene) "IM GLEE for TK/CML!!" IM = Imantinib GLEE = Gleevab |
|
Trastuzumab
|
Breast Cancer txmt
Monoclonal Ab for erbB2 receptor |
|
Daunomycin
|
Anticancer: Antibiotic
Acts on TOPOISOMERASE II SE: CARDIOMYOPATHY |
|
Idarubicin
|
Anticancer: Antibiotic
Acts on TOPOISOMERASE II |
|
Doxorubicin
|
Anticancer: Antibiotic
M: Intercalates into DNA strand & Oxidized Fe & Cu to produce oxygen fee radicals that damage DNA SE: CARDIOMYOPATHY |
|
Bleomycin
|
Anticancer: Antibiotic
M: Intercalates into DNA strand & Oxidized Fe & Cu to produce oxygen fee radicals that damage DNA SE: PULMONARY TOXICITY |
|
Tamoxifen
|
Anticancer: Hormonal
Estrogen receptor antagonist Breast Cancer |
|
Dactinomycin
|
Anticancer: Antibiotic
PEDIATRIC solid tumors and choriocarcinomas M: inhibiits DNA trnascription -> blocks RNA polymerase -> DNA brekas |
|
Leuprolide
|
Gonadotropin-realeaseing hormone analog
Prostate cancer |
|
Mitocycin
|
Anticancer: Antibiotic
SE: THROMBOCYTOPENIA |
|
Vincristine
|
Anticancer: Antispindle, Vinca alkaloids
M: binds tubuline preventing polymerization of MT -> arrests cell at metaphase -> Cell death SE: NEUROTOXICITY (not myelosuppresion!) PLANT ALKALOID GROUP |
|
Vinblastine
|
Anticancer: Antispindle, Vinca alkaloids
M: binds tubuline preventing polymerization of MT -> arrests cell at metaphase -> Cell death SE: MYELOSuPPPRESSION PLANT ALKALOID GROUP |
|
Paclitaxel
|
Anticancer: Antispindle, Taxanes
M: binds tubuline & STABILIZES -> arrests cell at metaphase -> Cell death COLON CANCER is RESISANT b/c of efflux pumps PLANT ALKALOID GROUP |
|
Docetaxel
|
Anticancer: Antispindle, Taxanes
M: binds tubuline & STABILIZES -> arrests cell at metaphase -> Cell death COLON CANCER is RESISANT b/c of efflux pumps PLANT ALKALOID GROUP |
|
Irenotecan
|
Anticancer: Topomerase I inhibitor
M; Topomerase I inhibition -> single strand break -> cell death/apoptosis SE: myelosuppression & DIARRHEA PLANT ALKALOID GROUP |
|
Etoposide
|
Anticancer: Topomerase II inhibitor
M; Topomerase II inhibition -> single strand break -> cell death/apoptosis SE: myelosuppression & ALOPECIA PLANT ALKALOID GROUP |
|
Cyclosporine
|
Immunosuppressant: T Cell Blocker
Organ Trasplant, RA, Psoriasis M: Binds CYCLOPHILIN -> Complex inhibits calcineurin -> v IL-2 production -> T cells |
|
Tacrolimus (FK506)
|
Immunosuppressant: T Cell Blocker
Organ Transplant More potent & less SE than cyclosporine M: Binds FKBP -> Complex inhibits calcineurin -> v IL-2 production -> T cells Nephrotoxicity |
|
Sirolimus
|
Immunosuppressant: T Cell Blocker
Organ Transplant, ANTIFUNGAL agent USED IN ACUTE REJECTION M: Binds FKBP -> DOES NOT inhibit calcineurin -> v IL-2 production -> T cells & B CELLS! Less nephrotoxitcity than cyclosporine and Tacrolimus (possibly due to lack of calcineurin inhibition) |
|
Azathioprine
|
Immunosuppressant: cytotoxic Agent (Purine Syn Inhibitior)
M: ADENINE analog; ihibits de novo synthesis of PURINES SE: **ALLOPURINOL INTERACTION** Allopurinol inhibits XO, which inactivates 6-MP (azathioprine) -> PANCYTOPENIA |
|
Mycophenolate
|
Immunosuppressant: cytotoxic Agent (Purine Syn Inhibitior)
M: inhibits IMP dehydrogenase; ihibits de novo synthesis of PURINES |
|
Cyclophosphamide
|
Immunosuppressant: cytotoxic Agent
M: DNA crosslinks between and within DNA strands. This leads to cell death Better known of LIVER transplants SE: HEMORAGIC CYSTITIS, BLADDER NEOPLASMS "Im gonna go cyclo on my hemorage cystitis bladder!!" |
|
Leflunomide
|
Immunosuppressant: cytotoxic Agent (Pyrimidine Syn Inhibitior)
M: inhibits dihydroorotate dehydrogenase; inhibits de novo synthesis of PYRIMIDIES SE: Alopecia |
|
OKT3
|
Immunosuppressant: Antibody Reagents
M: Murine monoclonal Ab to T3 (CD3) ag of T Cells |
|
Basiliximab
|
Immunosuppressant: Antibody Reagents
"Li-mabs" M: Human monoclonal Ab that block IL2 receptor (CD25) on T lymphocytes |
|
Daclizumab
|
Immunosuppressant: Antibody Reagents
"Li-mabs" M: Human monoclonal Ab that block IL2 receptor (CD25) on T lymphocytes |
|
Etanercept
|
Immunosuppressant: Cytokine Inhibitor
U: Autoimmune disease (RA, Crohn Disease) M: Human monoclonal Ab that binds TNF-alpha SE: LUPUS-like syndrome "EI EI LUPUUUUUUS...TNF-alpha now" |
|
Infliximab
|
Immunosuppressant: Cytokine Inhibitor
U: Autoimmune disease (RA, Crohn Disease) M: Human monoclonal Ab that binds TNF-alpha SE: LUPUS-like syndrome "EI EI LUPUUUUUUS...TNF-alpha now" |
|
Side effect for Propothiouracil?
|
Agranulocytosis & Aplastic anemia
|
|
When do you use Liothyronine?
|
Myxedema coma
|
|
SE of alendronate?
|
Bisphosphonate - used to tx OSTEOPOROSIS; inhibits Osteoclasts
SE - esophageal erosion |
|
What drugs antagonizze thyroid hormone?
|
B Blockers (ie propanolol)
|
|
Inhibits HMG-CoA reductase and thus block cholesterol syn?
Main effect? SE? |
MOA for Fluvastatin
reduction in Total cholesterol and LDL SE = ^ liver fxn tests, MYOSISTIS & RHABDOMYOLYSIS |
|
Inhibits lipolysis in adipose tissue, reduing the availabe fatty acid in liver for VLDL and TG syn
Main effect? SE? |
MOA for Niacin
^ HDL SE = FLUSHING, PURITIES (itching), glucose intolerance, HYPERURICEMIA, & GOUT |
|
Activates lipoprotein lipase
Main effect? SE? |
MOA for Fibrate
v TG SE = Gi distress, anemia |
|
Bind blie acinds in intestin and inhibtis recycling in ileum
Main effect? SE? |
MOA for Cholestyramine (Sequesterin)
Usually used w/ STATIN to v LDL SE: Bloating, STEATTHOREA, difficult to take, can affect absorption of medicine |
|
Meloxicam
|
LONG duration NON-Cox selective NSAID
SE: gastritis |
|
Piroxicam
|
LONG duration NON-Cox selective NSAID
SE: gastritis |
|
Indomethacin
|
NON-Cox selective NSAID
SE: gastritis |
|
Celecoxib's SE?
|
Sulfa rxn
THROMBOSIS - b/c inhibits prostacycline & not TXA2 which is a procoagulant Same SE for all Cox-2 selective NSAIDs... |
|
COX-2 have bad interactions iwth what 2 drugs?
|
1) B-Blockers (propanolol)
2) SSRIs |
|
Can use penicillin for what 3 infections?
|
1) Group A strep
2) N. menigitis 3) Syphilis |
|
Clavulanate?
|
Penicillinase Inhibitor (use with amoxicillin)
|
|
DOC for Listeria?
|
Ampicillin
|
|
What 3 bacteria to NOT use cephalosporins against?
|
1)MRSA
2)Enterococci 3)Listeria monocytogenes |
|
SE for Sulfonamides?
MOA? Cool feature? |
1) STEVENS-JOHNSON SYN
2) Crystal-induced nephropathy 3) In patients WITH G6PD deficiency = Intravasuclar hemolysis and ANEMIA 4)FETUS = KERNICTERUS PABA analog inhibting dihydropteroate syn inhibiting PURINE syn CNS penetration |
|
Trimethoprim MOA?
|
FOLATE analong inhibting dihydropteroate syn inhibiting PURINE syn
Used with Solfonmaides |
|
SE of General Tetracyclines?
Additional for Demeclocyline? Minocycline? |
1) Phototoxic SKIN RXN
2) Fatty liver 3)Tooth discoloration Demenclocycline = Nephrogenic diabetes insipidus Minocycline = Vertigo, ataxia |
|
Erythromycin binds what causing GI motility (N/V)?
|
Motilin
|
|
Clindamycin treats?
|
Anaerobic bacteria & Bacteroides fragilis
No effect on aerobic G- Clindamycin = Closet (anaerobic) causes SE of C difficile colitis |
|
SE of Aminolycosides?
Only AG taken orally & therefore no need for renal adjustment AG used as aerosol for children? |
1) Nephrooxicity
2) Ototoxicity 3) Vestibulotoxicity = NM Blockade/Ataxia Neomycin Tobramycin |
|
Production of what enzyme inactivates AGs (confers bacterial reistance)
Concetration dependent killing? (y/n) Post-antiiotic effect? |
Transferase enzyme
Yes Yes |
|
Fluroquinolone SE
|
1) Arthropathy/Tendinitis
2) Hyper/Hypoglycemia (BOTH?@) 3) Photosensitivity Also is Concertration DEPENDENT killing and POST-antibiotic effect |
|
VanA resistance has terminal?
Vancomycin cidal exception? |
D-alanyl-D-LACTATE
Baericidal for all G+ except ENTEROCOCCI = BacterioSTATIC) Also Post antibiotic effect |
|
Last-ditch effert for Vanc resistant illness?
SE of drug? |
Linezolid
1) CYTOPENIAS (w/ > 2 weeks use) 2) SEROTONIN SYN |
|
SE of Daptomycin?
|
Skeletal MYOPATHY & Peripheral NEUROPATHY
|
|
Invermectin usd to treat?
|
Anti-Protozoal
Strongyloids (Nematodes) ONLY b/c only nematodes have GABA receptors |
|
Iodoquinol
|
Anti-Protozoal
Effective against AMOEBIASIS |
|
Sodium Antimoney Gluconate
|
Anti-Protozoal
Effective against LEISHMANIASIS by inhibiting PFK thereby depleting energy |
|
Black urine caused by?
|
Anti-Malarials: Chloroquine & Amodiaquine
Affective against RBC stage ONLY (ineffective against Tissue stages) |
|
Primaquine
CONTRA? |
Anti-Malarial
Effective against TISSUE stages (ineffective against rbc stages) Radical cure for P vivax & ovale CONTRA: patients with G6PD Deficiency -> intavascular hemolysis & ANEMIA |
|
Pyrimethamine
|
Anti-Malarial: DHFR Inhibitors (folate analogs)
"iMeths" |
|
Trimethoprim
|
Anti-Malarial: DHFR Inhibitors (folate analogs)
"iMeths" |
|
SE of Isonizazid?
|
1) PELLAGRA
2) Age-dependent HEPATITIS 3) v VITAMIN B6 (supplements needed) 4) Drug inteactions with anticonvulsants - Phenytoin, Carbamezepine |
|
Antidote for Cyanide poisoning?
|
Sodium Nitrate
Sodium Thiosulfate |
|
Antidote for Methanol poisoning?
|
Methypyrazole & Ethanol
Prevent toxicity by INHIBITING METABOLISM to formic acid |
|
Benzene poisoning causes?
|
Leukemia & aplastic anemia
|
|
Acetaminophen OD antidote?
|
Oral N-Acetylcystteine
Prevent toxicity by METABOLISM; brings v NAPQI (toxic intermediate; makes more GSH available) |
|
All toxic metals antidote?
|
Metal Chelators:
1) Succimer 2) EDTA = SE: may remove essential metals such as Zn |
|
Senna
|
Laxative: Stimulant
|
|
Cascara
|
Laxative: Stimulant
|
|
Sulfasalazine
|
Tx Inflammatory Bowel Disease
formed by Sulfapyridine + 5-ASA SE: sulfapyridine causes a lot of toxicities |
|
Olsalazine
|
Tx Inflammatory Bowel Disease
formed by 2 5-ASA no SE from sulfapyridine |
|
St Johns Wort
|
Tx Depression
contains HYPERICINE - bind FXR receptor and ^ drug (ie cyclosporin & theophyline) metabolism by CYP450 CONTRA = MAO inhibitors |
|
Echinacea
|
Tx common cold/flu
CONTRA: immunosuppressants (ie corticosteroids) |
|
Cranberry Exract
|
Tx UTI
|
|
Garlic
|
contains antioxidants: 1)Indole-3-cabinol & 2)Allicin
CONTRA: NSAIDs (ie aspirin, ibuprofen, acetominophen, etc) |
|
Ginseng
|
contains antioxidants: 1)Indole-3-cabinol & 2)Allicin
CONTRA: NSAIDs (ie aspirin, ibuprofen, acetominophen, etc) |
|
CAM's not used anymore
|
Yohimbe, coMfrey, Chaparral, ephedrA
"YMCA" |
|
Genistein
|
Binds esrogen B receptors selectively
has many antioxidant properties |