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13 Cards in this Set
- Front
- Back
6 classes of oral type 2 drugs
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sulonylurea
biguanides alph glucosidase TZD dipep-pep-IV-inhib incretin mimetic |
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3 ways that sulfonylureas work?
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increase release of insulin from beta cells
increase insulin release in glucose presence increase insulin effect (more glucose uptake by muscle/fat cells) |
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what is the difference between 1st and 2nd generation sulfonylureas?
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2nd is 10-100x more potenet
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metformin is of the ____class, and it is unique in that it is the )______
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biguanide
most prevalent type 2 oral drug |
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4 mechanisms of metformin?
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inhibits glucose absorb
decrease hepatic glu output improve insulin sensitivity increases periph glu uptake/use |
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alpha glucosidase inhibitor action?
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inhbiting the enzyme that breaks down carbs in the gut
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target of TZDs?
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PPAR-y
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how does TZD work?
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decrease insulin conc?
decfrease glu conc increase insulin sensitivity |
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TZD effect on fat?
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TZD keeps fat in fat tissues thereby increaseing insulin sensitivity of liver/msucle
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How do pioglitazone (actos) and rosiglitazone (avandia) work?
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decrease blood sugar by increasing sensitivity to insulin,
DOES NOT increae insulin release decreases hepatic glucose output |
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What does the enzyjme DPPIV do?
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breaks down incretin
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How does Januvia work?
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inhibits DPPIV, thereby prolonging effect of incretin, which helps pancreas make insuilin after we eat
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exenatide and pramlintide are ____Drugs. Exenatide is a ____analog, and Pramlintide is a ____analog, which is co-secreted with____.
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incretin mimetic
incretin analog amylin insulin |