Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
Strength of interaction between drug and its receptor
|
Affinity
|
|
Selectivity of a drug for its receptor
|
Specificity
|
|
Amount of drug necessary to elicit a biologic effect
|
Potency
|
|
Ability of drug to produce a biologic effect
|
Efficacy
|
|
Ability of a drug to produce 100% of the maximum response regardless of the potency
|
Full agonist
|
|
Ability to produce less than 100% of the response
|
Partial agonist
|
|
Ability to bind reversibly to the same site as the drug and without activating the effector system
|
Competitive antagonist
|
|
Ability to bind to either the same or different site as the drug
|
Noncompetitive antagonist
|
|
Mechanism of action (MOA) utilizes intracellular receptors
|
Thyroid and steroid hormones
|
|
MOA utilizes transmembrane receptors
|
Insulin
|
|
MOA utilizes ligand gated ion channels
|
Benzodiazepines and calcium channel blockers
|
|
Median effective dose required for an effect in 50% of the population
|
ED50
|
|
Median toxic dose required for a toxic effect in 50% of the population
|
TD50
|
|
Dose which is lethal to 50% of the population
|
LD50
|
|
Window between therapeutic effect and toxic effect
|
Therapeutic index
|
|
Drug with a high margin of safety
|
High therapeutic index
|
|
Drug with a narrow margin of safety
|
Low therapeutic index
|