Pharm Neurotransmission

Front 1

chemical cellular communication

Back 1

neurotransmitter

Front 2

electrical cellular communication

Back 2

1) passive conduction
2) active conduction

Front 3

Boutons

Back 3

nerve terminals

Front 4

cellular charges

Back 4

due to differential ionic concentrations

Front 5

normal resting potential

Back 5

-80 mv (most cells)

Front 6

Na

Back 6

IC: 15 mM EC: 145 mM

Front 7

K

Back 7

IC: 145 mM EC: 5 mM

Front 8

Cl

Back 8

IC: 10 mM EC: 150 mM

Front 9

Ca

Back 9

IC: 0.0001 mM EC: 2 mM

Front 10

primary contribution to resting charge

Back 10

K channels
(only channel open at rest)

Front 11

dendritic conduction

Back 11

passive electrical process

Front 12

axonal conduction

Back 12

1) active electrical process
2) involves voltage-gated Na and K channels (some Ca also)
3) Na-K ATPase to restore chemical equilibrium
4) signal initiated at axon hillock by internally ligand-gated Na channels
5) Myelinated vs Non-myelinated axons

Front 13

factors leading to increased conduction rates

Back 13

1) myelination
- decreased capacitance
- saltatory conduction
2) lower resting potential
3) increasing Na channel density
4) increasing axonal diameter

Front 14

synaptic transmission

Back 14

1) Ca channel stimulation
2) Ca released from storage in Sarcoplasm
3) increased Ca leads to biochemical change allowing fusion of vesicles with inner cell membrane
4) Ca rapidly removed back into sarcoplasm
5) fused vesicles open to synaptic space, releasing contents into synaptic cleft
6) vesicles reformed by endocytotic process, and can then be refilled

Front 15

vesicles

Back 15

contain 1 quanta of neurotransmitter
5,000-10,000 molecules neurotransmitter
other compounds also in vesicles