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11 Cards in this Set
- Front
- Back
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Neurotransmitters |
carry signals to other neurons -- can cause excitation or inhibition |
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Mechanism of CNS Drugs |
work by modifying the synaptic transmission -- increase or decrease transmission at a specific synapse |
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Sedative-hypnotics and antianxiety drugs |
Both have a calming and relaxing effect on a patient -- depress the CNS -- larger doses can produce drowsiness or sleep |
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Benzodiazepines |
Most commonly used for anxiety but can also promote sleep -- safer than barbituates -- can cause dependence if used for extended period of time |
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Benzodiazepines - MOA |
Increase inhibition at the CNS synapses that use GABA which causes inhibition at the neurons throughout the brain and SC |
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Benzodiazapines - pharmacokinetics |
Very lipid soluble, 1 oral dose at bedtime, absorbed from the GI tract, dist. uniformly throughout the body, metabolized in the liver, excreted through the liver |
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Beta Blockers |
Decrease anxiety without causing anxiety -- decrease anxiety by blocking the SNS |
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Affective Disorders |
Mental disorders characterized by a disturbance in pt's mood -- ie depression, bipolar syndrome |
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depression |
neurochemical imbalance may be underlying cause -- many patients undergoing rehab will be depressed |
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Antidepressant pharacokinetics |
Admin. orally, initial dosages start out small and increased slowly until beneficial effects seen, metabolized in liver |
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Bipolar disorder |
manic-depressive, mood swings from one extreme (mania) to the other (depression) -- imbalance between inhibitory and excitatory neurotransmitters |
