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42 Cards in this Set
- Front
- Back
what are the 4 main classes of ART?
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Fusion Inhibitors
NRTI's NNRTI's PI's |
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what is the MOA of Fuzeon?
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to prevent GP120 from binding to CD4 cells
90mg SC BID. refrigerate. |
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what are some AE of fuzeon?
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local site reactions, induration, nodules or cysts, itching, redness, bruising, pain
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what is the only NRTI that does not require renal dose adjusting?
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abacavir ABC
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what is the MOA of NRTI's?
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to inhibit RT by competatively incorporating themselves into DNA thereby causing chain termination
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what is truvada?
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an NRTI combo:
emtriva + Viread 1 tablet QD |
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what major side effect does DDI cause?
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N/V/D stomach pain
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what two NRTI's are associated with pancreatitis??
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didanosine DDI and stavudine D14
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which ART's are associated with peripheral neuropathy?
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Didanosine: DDI
Stavudine: D14 Hydroxyurea Isoniazide |
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how can you prevent peripheral neuropathies in HIV patients?
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give vitamin B6 complexes
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lactic acidosis w/ hepatic steatosis, SOB, fatigue, N/V are especially associate with which NRTI's?
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Didanosine DDI
Stavudine D14 |
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which NRTI's esp. cause Lipoatrophy?
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Didanosine: DDI
Stavudine: D14 |
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which NRTI is contraindicated in p who have extremely elevated TC and TRG's?
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stavudine: D14
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which NRTI causes anemia and neutropenia?
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zidovudine
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which NRTI causes a hypersensitivity reaction?
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abacavir
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what is the MOA of NNRTI's?
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to inhibit RT by non competitively attaching to and inhibiting the enzyme itself
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name two NNRTI's?
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nevirapine NVP
Efavirenz: sustiva: EFV |
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what is the only ART with CNS toxicity?
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sustiva: EFV
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which NNRTI has the greatest potential for liver toxicity?
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nevirapine
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which NNRIT most commonly causes a rash?
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nevirapine
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what is the MOA of Protease Inhibitors?
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prevent HIV from being successfully assembled and released from infected CD4 cells
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name 4 ART's that are inducers of drug metabolism
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amprenavir, efavirenz, tipranavir, nevirapine
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name a class of ART's that inhibit drug metabolism?
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PI's
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which ART is a potent inhibitor of the CYP450 3A and is used to reduce clearance of other PI's?
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Ritonavir
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which Two ART's are absolutely contraindicated to use together because they antagonize each other's metabolism?
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zidovudine and stavudine D14
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which natural OTC supplement/depression treatment is contraindicated in the use of PI's and NRTI's because it is a powerful inducer of metab?
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st. john's wart
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what is the preferred NRTI based regimen according to our text?
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efavirenz: EFV
lamivudine: 3TC zidovudine:AZT |
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what is the preferred PI based regimen according to our text?
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Ritonivir
lamivudine zidovudine |
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which ART do you associate the most with diarrhea?
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nelfinavir
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which PI's are associated with diarrhea?
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Nelfinavir
Saquinavir Kaletra |
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which class of ART's causes lipodystrophy: symptoms of increased abdominal girth, breast size and/or buffalo hump?
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PI's
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which ART is the only "cholesterol friendly" ?
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atazanavir
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which class of ART's is notorious for increasing the cholesterol?
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PI's esp TRG Ritonivir containing regimens
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which class is known to increase GLUCOSE?
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PI's especially indinavir
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which PI's causes an increase in bilirubin?
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indinavir
atazanavir |
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which ART causes numbness around the mouth?
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ritonivir
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which PI's cause rash?
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F-amprenavir
Amprenavir Tipranavir |
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which ART is contraindicated to use with didanosine?
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tenofovir.
must decrease DDI dose. if < 60kg: 200mg if > 60kg: 250mg |
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which two drugs need to be separated by two hours if given together if using the EC formulation?
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didanosine decreases tipranavir levels
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when should didanosine be taken in relation to meal time?
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30 minutes before or 2 hours after except with tenofovir
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when should efavirenz be taken in relation to meal time?
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on an empty stomach
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which ART, when taken with food increases the bioavailabilty ?
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atazanavir
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