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20 Cards in this Set

  • Front
  • Back
True or False
The FDA regulates medical devices like intrauterine contraceptive systesms (Para Guard, Mirena) and biologic agents such as vaccines.
TRUE
(VARNEY Pg. 252)
The FDA does not develop, manufacture, or test drugs.
TRUE OR FALSE
TRUE
(Varney4-p252)
High potential for abuse and no current accepted medical use.
WHAT FDA CLASSIFICATION OF CONTROLLED SUBSTANCES IS THIS? (give examples)
I II III IV V
schedule I
Ex: Heroin and LSD
(Varney4-254)
Many agents are metabolized through the cytochrome P-450 pathway.
What does this pathway do?
This pathway tends to affect the metabolism of drugs by slowing or accerlerating drug clearance
(Varney4-256)
Protein binding initially buffers the action of a drug but also has the effect of prolonging its half-life.
IS THIS STATEMENT TRUE
YES!
(Varney4-258)
The more advance the pregnancy, the lower the serum concentration of protein
(True or False)
True
(Varney4-258)
Most drugs transfer across the placenta by WHAT KIND OF DIFFUSION?
(simple or facilitated)
Most drugs transfer across the placenta by simple diffusion, although some are carrier midiated, or use facilictated diffusion.
(Varney4 259)
Due to an increase in the GFR of a pregnant woman, water-soluble drugs clear more rapidly.
True or False
True
(Varney4-259)
Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in preg. women clearly outweights any possible benefit.
WHAT CATEGORY IS THIS?
A B C D or X
X
The drug is contraindicated in women who are or may become pregnant.
(Varney 260)
The period of organogenesis- between __ to __ weeks
postfertilization or __ to __ gestational weeks- is the most ____period for exposure to _________.
FILL IN THE BLANKS
The period of organogenesis- between 3 TO 8 weeks
postfertilization or 5 TO 10 Gest.weeks - is the most CRITICAL period for exposure to TERATOGENS.
(Varney4-p 260)
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk.
WHAT CATEGORY IS THIS?
A B C D or X
D
Varney4-260
Either studies in animals have revealed adverse effects on the fetus (teratogenicor embryocidal or other) or there are no controlled studies in women and animals are not available. Drugs should be given only if the potential benefit justifiesthe potential risk to the fetus.
WHAT CATAGORY IS THIS?
A B C D or X ?
C
(Varney4-260)
Too much Vitamin A can cause WHAT?
Too much vitamin A can cause spontanous Abortion, CNS defects, Cardiovascular, facial dysmorphia, mental retardation and cleft lip;palate
(Varney4-263)
TRUE OR FALSE:
Once organogenesis has been completed, drugs still remain a potential problem
True
(Varney4-264)
Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause premature closure of the ductus arteriosus and Necrotizing enterocolitis of the fetus (True or False)
True
(Varney 263)
When giving Magnesium during labor and the 2nd stage, what must you be aware of about the NB?
Magnesium sulfate, as a tocolytic or treatment for preeclampsia, may result in an infant who is lethargic and hypotonic at birth.
(Also need to be aware of this when using it for Pre term births and neuro benefits)
(Varney4-268)
So if you get a client who has been managing her gestational diabetes with oral hypoglycemics What must you watch out for in the NB?
Oral hypoglycemics have been implicated with profound neonatal hypoglycemia since placental transfer is relatively easy. (A NB who is jitter, irritable and has a low DFS)
IU fetal death has also been reported.
(Varney4-268)
As a Midwife, when prescribing drugs to the breastfeeding mom, What Must you keep in Mind?
Use the lowest dose for the shortest time that is therapeutic
When ever possible choice an agent that:
Is used in peds
Has a short half-life
Has a milk plasma ratio of 1 or less
Is not sustained released
(Varney4-271)
Movement of drug from site of entry into the body
Affected by cell membranes, blood flow, drug solubility, pH, drug concentration, dosage form
WHAT PHARMACOKINETICS DOES THIS FOLLOW? (Absorption-Distribution or Metabolism)
ABSORPTION

MW/WHNP certification review guide pg 57
What is this?:

percentage of active drug that is absorbed and available to the target tissue
BIOAVAILABILITY

MW/WHP Certification Review Guide pg 57