Pharm Exam 2 - ß-Adrenergic Receptor Agonists/antagonists

Front 1

norepinephrine

Back 1

mixed α & ß agonist; selective, α-1/α-2, only ß-1

clinical use: ↑BP

Front 2

epinephrine

Back 2

mixed α & ß agonist; non-selective, acts on ß-1 and ß-2

clinical use: asthma, cardiac stimulant, anaphylactic shock

Front 3

ephedrine

Back 3

mixed α & ß agonist; non-selective partial agonist, acts on ß-1 and ß-2

not a catechol - resists degradation

clinical use in anesthesia for drug induced HYPOtension

Front 4

ß-1 acts on...

Back 4

acts on heart, kidney

Front 5

ß-2 acts on...

Back 5

acts on respiratory, uterine and vascular smooth muscle, liver, skeletal muscle, pancreas

Front 6

ß-3 acts on...

Back 6

acts on adipose tissue

Front 7

all ß receptors couple to ____ and ↑____

Back 7

Gs, cAMP

Front 8

ß-1 stimulation causes...

Back 8

heart - increased HR and force of contraction
kidney - stimulates renin release

Front 9

ß-2 stimulation causes...

Back 9

smooth muscle - bronchial, vascular, and uterine smooth muscle
liver - glycogenolysis, gluconeogenesis (↑blood glucose)
skeletal muscle - ↑K+ uptake = ↑firing of motor neuron at NMJ
pancreas - release insulin

Front 10

ß-3 stimulation causes...

Back 10

breakdown of triglycerides, ↑free fatty acids

Front 11

specific effect of ß-1 agonists on heart

Back 11

SA node - ↑HR
atria/ventricle - ↑contractility
av node - ↑conduction velocity

his-purkinje system NOT INCREASED

beta blockers: ↓all of the above

Front 12

specific effect of ß-1 agonists on kidney

Back 12

activates renin-angiotensis-aldosterone system at juxtaglomerular apparatus (JGA)

renin is released when:
renal perfusion is low, ↓plasma Na+, SANS activates ß-1

Front 13

dobutamine

Back 13

selective agonist; activates ß-1 receptors in heart

clinical use: cardiogenic shock/acute heart failure

Front 14

isoproterenol

Back 14

non-selective ß-1 & ß-2 agonist

ß-1: ↑HR and force of contraction
ß-2: ↓PVR, vasodilation

clinical use: bronchodilator (ß-2)

Front 15

dopamine

Back 15

mixed-acting agonist

D1: vasodilates renal arteries
ß-1: cardiac stimulant
α-1: ↑BP

clinical use: ↑cardiac output during congestive heart failure

Front 16

-olol family

Back 16

ß blockers

Front 17

non-selective ß blockers

Back 17

blocks ß-1 and ß-2

Front 18

cardioselective ß blockers

Back 18

blocks ß-1 only

Front 19

clinical effects of ß blockers

Back 19

heart - ↓HR and force of contraction = ↓CO
kidney - ↓renin
eye - ↓AQUEOUS HUMOR SECRETION

Front 20

propanolol

Back 20

prototype of non-selective ß blockers

clinical uses: hypertension, angina, arrhythmias

Front 21

diabetics and ß-2 blockers

Back 21

avoid combination

Front 22

labetolol

Back 22

mixed α/ß blocker

clinical use: hypertensive crisis, pheochromocytoma

Front 23

carvedilol

Back 23

mixed α/ß blocker

clincal use: blocks SANS and compensatory SANS effects in heart failure