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9 Cards in this Set
- Front
- Back
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Where are esters and amide types metabolized?
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Esters in plasma via pseudocholinesterases. Amides by hepatic P450 cytochromes.
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Which type of LA is associated with more allerigic reactions?
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Amide types because degradation produces PABA.
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Which LA has the highest risk of hypotension and bradycardia?
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Bupivocaine
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What is the result of prilocaine or benzocaine OD and how do you Tx?
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Methemoglobinemia b/c the metabolite o-toluidine can oxidize hemoglobin to methemoglobin. Tx with methylene blue.
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What nerve fiber characteristics would encourage LA block?
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Rapidly and reptitively firing. Thin. Outer position in nerve bundle.
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What is the order in which nerves are blocked by an LA from first to last?
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Sympathetic, pain, sensory, proprioception, motor
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Which type of LA, ester or amide, has a longer duration of action?
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Amide type LAs b/c more resistent to metabolism
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Would you want to increase or decrease the pH of the LA solution to improve the speed of block onset?
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Want to increase the pH. Often administer the Rx with sodium bicarbonate.
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Does pregnancy increase to decrease the likelihood of LA toxicity?
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Pregnancy increases the risk of LA toxicity.
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