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15 Cards in this Set
- Front
- Back
Irreversible condition resulting from the use of antipsychotics, reserpine at high doses, and MPTP (by-product of illicit meperidine analog) |
Drug induced Parkinsonism
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Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross the BBB
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L-dopa
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This is combined with L-dopa, inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L-dopa and allows for fewer SE's (GI distress, postural hypotension, and dyskinesias)
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Carbidopa
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Clinical response that may fluctuate in tx of Parkinson's dx
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"On-off-phenomenon"
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Anti-Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
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Levodopa
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Ergot alkaloid that is a partial agonist at D2 receptors in the brain, used for patients who are refractory or cannot tolerate levodopa, causes erythromelalgia
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Bromocriptine
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Non ergot agents used as first-line therapy in the initial management of Parkinson's
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Pramipexole and ropinirole
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Enhances dopaminergic neurotransmission SE's include CNS excitation, acute toxic psychosis and livedo reticularis
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Amantadine
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Inhibitor of MAO type B which metabolizes dopamine, used adjunct to levodopa or as sole agent in newly diagnosed patients
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Selegiline
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Inhibitors of catechol-O-methyltransferase (COMT), used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's)
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Entacapone and Tolcapone
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Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine-like side effects
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Benztropine
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Agent effective in physiologic and essential tremor
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Propranolol
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Agents used in Huntington's Disease
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Tetrabenazine (amine depleting drug), Haloperidol (antipsychotic)
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Agents used in Tourette's dx
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Haloperidol or pimozide
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Chelating agent used in Wilson's disease
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Penicillamine
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