Pharm - Ch 12 - Drugs Used In The Treatment Of Angina Pectoris

Front 1

MOA of pFOXis

Back 1

shift heart metabolism for energy from FAs to glu

Front 2

ranolazine and trimetazidine are

Back 2

pFOXis

Front 3

reduce O2 requirement:

Back 3

nitrates, Ca Ch blockers, B blockers

Front 4

increase O2 delivery by reducing vasospasm

Back 4

nitrates and CCBs

Front 5

tx for unstable angina

Back 5

angioplasty and anti-clotting meds

Front 6

abciximab, eptifibatide and tirofiban are:

Back 6

platelet glycoprotein IIb/IIIa inhibitors used for unstable angina

Front 7

amyl nitrate, nitroglycerin, isosorbide dinitrate

Back 7

nitrates

Front 8

MOA of nitrates

Back 8

dinitration in smooth muscle cells causes release of NO; stimulates guanylyl cyclase to increase cGMP - smooth muscle relaxation

Front 9

effect of nitrates on CV system

Back 9

venodilation, reduced CO and preload; relaxed arteries causes increased coronary flow, reduced afterload; reversal of spasm

Front 10

compensatory effect of nitrates

Back 10

reflex tachycardia and increased contraction force

Front 11

nitrate effect on other organs (not CV)

Back 11

relax smooth muscle, reduce platelet aggregation (IV form)

Front 12

tolerance of nitrates develop after how long?

Back 12

8-10 hr

Front 13

combo of nitrates with what drug can cause increased hypotension and hypoperfusion of organs?

Back 13

sildenafil and other ED drugs

Front 14

MOA of ED drugs (sildenafil):

Back 14

inhibit phosphodiesterase that metabolizes cGMP, increases amount of cGMP available which increases relaxation of erectile smooth muscle, this allows inflow of blood and erection

Front 15

at high blood concentrations, what is an important nitrate toxicity

Back 15

methemoglobinemia (can be used to tx cyanide poisoning)

Front 16

diltiazem, nifedipine and verapamil are:

Back 16

CCBs

Front 17

MOA of CCBs

Back 17

block voltage gates L-type Ca channels (most impt in heart and smooth muscle); decreases contractility

Front 18

these can be used to treat AV node arrythmias

Back 18

diltiazem and verapamil; block Ca-dep conduction in AV node

Front 19

CCBs are effective against which types of angina?

Back 19

effort and vasospastic

Front 20

for atherosclerotic angina what drug combo do you use?

Back 20

CCBs and nitrates

Front 21

nimodipine is a CCB that is also approved to tx ___

Back 21

hemorrhagic stroke

Front 22

SE of CCBs

Back 22

constipation, pretibial edema, nausea, flushing, dizziness, heart failure, AV block, SA depression

Front 23

prophylactic tx of atherosclerotic and exercise-induced angina is by ___

Back 23

B blockers

Front 24

SE of beta blockers

Back 24

increased heart size, longer ejection period

Front 25

compensatory response of nitroglycerin

Back 25

increased cardiac force

Front 26

this drug is most likely to cause methemoglobinemia

Back 26

amyl nitrate

Front 27

drugs that cause ____ generally precipitate angina

Back 27

HTN or tachycardia

Front 28

SE of nitrates

Back 28

Postural hypotension, reflex tachycardia, hot flashes, and throbbing headache due to meningeal artery dilation

Front 29

Beta blockers are used for which type of anginal attack

Back 29

Classic

Front 30

Toxicity caused by nitroprusside and treatment

Back 30

Cyanide toxicity treated with sodium thiosulfate

Front 31

SE of beta blockers

Back 31

Bradycardia, SEXUAL DYSFUNCTION, decrease in HDL, and increase in Triglycerols (TG)

Front 32

CCBs block what type of Ca channels?

Back 32

L-type

Front 33

CCB contraindicated in CHF

Back 33

Verapamil

Front 34

CCB with predominate effect on arteriole dilation

Back 34

Nifedipine

Front 35

SE of CCB

Back 35

Constipation, edema, and headache

Front 36

Drugs used in the management of angina

Back 36

Aspirin, Nitrates, CCB, and Beta blockers

Front 37

Aspirin reduces mortality in unstable angina by

Back 37

Platelet aggregation inhibition

Front 38

Nitrate used for acute anginal attacks

Back 38

Nitroglycerin sublingual tablets

Front 39

Nitrate used to prevent further attacks

Back 39

Oral and transdermal forms of nitroglycerin

Front 40

Nitrate free intervals are needed due to

Back 40

Tolerance