Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
glycoprotein rec IIb and IIIa
|
fibrinogen rec
inc bining of firbrinogen to rec which inc plt binding |
|
|
ASA
|
txa2 inhib
prevent mi and stroke irrev bind cox 1and2 antiplt and antiinf cause ulcer and blding |
|
|
Dipyridamole
|
inhib plt agg
and phosphodiesterase in high lvls prevents emblization of prosthetic valves |
|
|
Indomethacin
|
inhib cox 1,2, and lipooxygenase
use w. neonate to close PDA |
|
|
Clopidogrel(plavix)
Ticlopidine |
antiplt
inhib ADP rec use instead of ASA for mi and stroke cause TTP,leukopenia,hemorrage agranulocytosis w/ Tic combine asa w/ clop |
|
|
Cilostazol
|
antiplits
PDE3 inhib for tx of intermittant claudication or PAD |
|
|
Iv Abciximaba
Eptifibatide Tirofiban |
antiplts
inhib IIb/IIIa rec by keeping fibrinogen from binding=no plt agg use for acute coronary disease and angioplasty |
|
|
Antithrombin 3
|
inactivates factors 2,9,10,11,12
which are part of intrinsic and 2 is common so works vivo and vitro |
|
|
LMW Heparin
|
anticoag
works vivo and vitro b/c inc antithromb3 by enhancing the serine protease activity -safe in preg side effects: blding,thrombocytopenia,osteoperosis |
|
|
Protamine
|
antidote to heparin
|
|
|
Dalteparin
Enoxaparin Danaparoid |
anticoags
Enox-lovenox Dana-safe in hypersens to heparin |
|
|
Argatroban
Bivalirudin |
thrombin inhib
inhib directly biv-unstable angina w/ PTCA |
|
|
Warfarin
|
-po
-inhib vit k factor synth 1972 -blocks gamma carboxylation factors -works in liver -only works in vivo -no preg -side effects are blding skin nec-in ppl w/ protein C def purple toe synd bone defects |
|
|
protein c
|
activated by thrombomodulin and thrombin ->combines w/ protein S to inactivate factor 5 and 8
|
|
|
Enoxaparin
|
lovenox
LMWH works against factor 10 more than 2 works longer than hep prevents DVT cuases: hemmorage,thrombocytopenia,local irritation not for prosthetic heart valves |
|
|
anticoag side effects
|
spinal and epidural hematoma
thrombocyto hyperlipidemia |
|
|
Phytonadione
|
antidote to warfarin
vit k1 |
|
|
PT/INR
|
checks warfarin pthwy
is for extrisic >2.5 times norm |
|
|
PTT
|
monitors heparin
should be 1.5 -2.5 times norm |
|
|
Alteplse
Reteplase |
TPA
recomb DNA clot specific no allergy rxn |
|
|
Streptokinase
|
like TPA
non specific causes allergies and hypotn dec plasminogen and 5 and 8 in circ |
|
|
Amino caproic acid
|
antidote to fibrinolytics
|
