Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
Oseltamivir use
|
Tx symptoms influenza
|
|
Oseltamivir MOA
|
NA inhibitor
prevents budding of HINI and H5NI |
|
Foscarnet uses
|
i.v. only
DOC CMA resistant to gancyclovir and cidofovir HSV, CMV, HIV |
|
RNA and DNA polymerase inhibitor
Tx CMV |
Foscarnet (i.v.)
|
|
Tx CMV resistant to cidofovir
not a prodrug |
Foscarnet (i.v.)
|
|
DOC CMV retinitis
(occular implant) |
Gancyclovir
prodrug guanosine |
|
Not a prodrug
Binds mRNA as terminator |
Fomivirsen
|
|
mRNA termination
CMV treatment |
Forivirsen
|
|
Fomivirsen
|
mRNA terminator
Tx CMV |
|
DOC Herpes Keratitis
|
Trifluridine
(opthalmic solution) |
|
Trifluridine
|
opthalmic solution
DOC Herpes Keratitis |
|
HIV
Fusion Inhibitors |
Enfurtide
(gp41, for last case decrease titer) Maraviroc (CCR5 only, gp120) |
|
Maraviroc
|
fusion inhibitor (HIV)
gp120 binds CCR5 tropic only |
|
Enfuvirtide
|
last resort drug to lower HIV titer
bind gp41 low T 1/2 |
|
CCR5 tropic drug only
|
Maravioc
fusion inhibitor (gp120) |
|
NRTIs
|
Lamividine
Abacavir Tenofovir Emtricitabine Zidovidine |
|
Zidovudine
|
NRTI
|
|
Lamivudine
|
NRTI
also HBV |
|
Abacavir
|
NRTI
|
|
Tenofovir
|
NRTI
|
|
Emtrictabine
|
NRTI
|
|
NRTI works even when resistant ot other NRTI
|
Tenofovir
|
|
NRTI resistance v. NNRTI resistance
|
NNRTI will all be resistant
NRTI have diff. mechanisms |
|
NNRTIs
|
Nevirapine
Efavirenz |
|
Integrase Inhibitors
|
Raltegravir
|
|
Ralegravir
|
Integrase Inhibitors
|
|
Nevirapine
|
NNRTI
|
|
Efavirenz
|
NNRTI
|
|
Protease Inhibitors
|
Ritonavir + Lopinavir
Atazanivir |
|
Ritonavir-Lopinavir
|
Protease Inhibitors
Rotonavir decreases CPY3A4 increase Lopinavir in plasma |
|
Atazanavir
|
Protease inhibitor
|