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102 Cards in this Set
- Front
- Back
ANS Drugs
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43
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Origin of PNS
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CN III, VII, IX, X; S2-S4
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Origin of SNS
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T1-L5
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PNS preganglionic fiber length?
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Long
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PNS postganglionic fiber length?
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Short
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SNS preganglionic fiber length?
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Short
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SNS postganglionic fiber length?
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Long
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Cholinergic transmission
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44
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Ach is primary transmiter for? 2
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Autonomic ganglia, PNS postganglionic
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Synthesis of Ach by?
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Choline acetyltranferase
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RLS of transport Ach?
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Choline acetyltranferase
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Ach transported into vesicle for storage by?
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VAT
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Proteins important in release of Ach?
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VAMPs, SNAPs
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Blocked by?
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Botox
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Termination is carried out by?
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AChE
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Adrenergic transmission
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45
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Norepi = primary transmitter for?
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SNS postganglionic
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Exceptions that use Ach?
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Sweat glands, skeletal muscle
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Exceptions that use dopa?
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Vasodilation of renal blood vessels
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Synthesis of norepi by? 3
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tyrosine hydroxylase, dopa decarboxylase, hydroxylase
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RLS of norepi transport?
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tyrosine hydroxylase
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Inactivation in cytoplasm occurs by?
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MAO
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Vesicular transporter inh by?
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reserpine
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Termination is carried out by?
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Diffusion & reuptake, esp by NET
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Inactivation in synaptic cleft by?
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MAO, COMT
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Mnemonic for G-protein classes of R?
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Qiss & qiq til ur siq of sqs (kiss and kick til ur sick of sex)
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R it stands for?
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a1, a2, b1, b2, M1, M2, M3, D1, D2, H1, H2, V1, V2
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a1 fx? 4
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vasoconstriction, mydriasis, incr intestinal sphincter tone, incr bladder sphincter tone
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a2 fx? 2
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dec symp outflow, dec insulin release
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b1 fx? 3
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incr HR, incr contractility, incr renin
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b2 fx? 6
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vasodilation, bronchodilation, incr HR, incr contractility, incr insulin release, dec uterine tone
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M1 fx? 2
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CNS, ENS
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M2 fx? 2
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Dec HR, Dec atrial contractility
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M3 fx? 6
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incr exocrine gland, incr peristalsis, bladder contraction, bronchoconstrition, miosis, accomodation
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D1 fx? 1
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relax renal SM
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D2 fx? 1
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modulate NT release, esp brain
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H1 fx? 4
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incr mucus production, bronchiolar contraction, pruritis, pain
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H2 fx? 1
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incr gastric acid
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V1 fx? 1
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SM contraction
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V2 fx? 1
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H2O perm & reabsorption in kidney collecting tubule
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Cholinomimetics
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57
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Nicotinic toxicity: 2
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CNS stim followed by depression, fasciculations and paralysis
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2 classes that act as AChE-I
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Carbamates, organophosphates
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Which are direct cholinomimetics? 4
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bethanechol, barbachol, pilocarpine, nicotine
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Which is used for postop/neurogenic ileus or urinary retention
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neostigmine, bethanechol
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which is used for myasthenia gravis 3
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neostigmine, edrophonium, pyridostigmine
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which is used for glaucoma 3
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physostigmine, carbachol, pilocarpine
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which is used for Sjogren's syndrome
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pilocarpine
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what is the prototype for carbamate?
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neostigmine
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what is the prototype for organophosphate?
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parathion
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Cholinergic blockers
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65
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Prototype?
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Atropine
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Mnemonic for atropine tox? 6
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hot as hare, dry as bone, red as beet, full as flask, blind as bat, mad as hatter
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Which is used for Parkinsons? 2
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benztropine, biperiden
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Which is used for motion sickness?
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Scopolamine
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Which is used to produce mydriasis and cycloplegia? 3
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atropine, cyclopentolate, tropicamide
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Which is used to reduce asthma/COPD Sx? 2
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ipratropium, tiotropium
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Which is used to reduce transient hypermotility? 3
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clycopyrrolate, dicyclomine, methscopolamine
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What reduces urgency, spasm, incontinence? 3
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oxybutynin, tolterodine, darifenacin
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Sympathomimetic
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73
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Direct general agonists 1
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epinephrine
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indrect general agonists, releasers 3
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amphetamine, ephedrine, tyramine
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indirect general agonsists, uptake inh 2
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Cocaine, TCA
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Selective for a1, a2, b1
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norepinephrine
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selective a1 > a2 2
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midodrine, phenylephrine
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selective a2 > a1 2
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clonidine, oxymetazoline
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selective for b1 = b2 1
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isoproterenol
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selective for b1 > b2 1
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dobutamine
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selective for b2 > b1 3
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albuterol, metaproterenol, terbutaline
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dopa agonists 2
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dopamine, bromocriptine
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which is used for ADHD? 2
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amphetamine, methylphenidate
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which is used for anaphylaxis? 1
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epinephrine
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which is used for asthma? 5
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epi, isoproterenol, albuterol, metaproterenol, terbutaline
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which is used for decongestion? 2
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phenylephrine, oxymetazoline
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which is used for glaucoma? 1
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epi
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which is used for narcolepsy? 2
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amphetamine, methylphenidate
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which is used for neurogenic hypotension? 1
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ephedrine
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which is used for obesity? 2
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amphetamine, methylphenidate
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which is used for shock, HF? 2
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dopamine, dobutamine
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which is used for urinary incontinence? 1
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ephedrine
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which is used to cause mydriasis? 1
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phenylephrine
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which is used to cause vasoconstriction? 3
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epi, phenylephrine, cocaine
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Adrenoreceptor blockers
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83
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nonselective alpha-blockers? 2
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phentolamine, phenoxybenzamine
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a1 selective 3
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prazosin, terazosin, doxazosin
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a2 selective 1
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yohimbine
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nonselective beta-blocker 5
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propanolol, carvedilol, labetalol, nadolol, timolol
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b1 selective 3
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metoprolol, atenolol, esmolol
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which is used for mastocytosis?
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phenoxybenzamine
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which is occasionally used for carcinoid tumor?
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phenoxybenzamine
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which is used for ED by direct injection? 2
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phentolamine, yohimbine
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which is used for HTN? 7
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prazosin, doxazosin, terazosin, atenolol, propanolol, metoprolol, timolol
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which is used for urinary retention? 4
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prazosin, doxazosin, terazosin, tamsulosin
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which is used for angina pectoris? 2
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propanolol, metaprolol
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which is used for arrythmia prophylaxis after MI? 3
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propanolol, metaprolol, timolol
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which is used for SVT? 3
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propanolol, esmolol, acebutolol
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which is used for HF? 3
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carvedilol, labetalol, metoprolol
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which is used for HCM? 1
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propanolol
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which is used for migraine prophylaxis? 1
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propanolol
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which is used for tremors? 1
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propanolol
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which is used for thyroid storm? 2
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propanolol, esmolol
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which is used for glaucoma? 1
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timolol
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