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102 Cards in this Set

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ANS Drugs
43
Origin of PNS
CN III, VII, IX, X; S2-S4
Origin of SNS
T1-L5
PNS preganglionic fiber length?
Long
PNS postganglionic fiber length?
Short
SNS preganglionic fiber length?
Short
SNS postganglionic fiber length?
Long
Cholinergic transmission
44
Ach is primary transmiter for? 2
Autonomic ganglia, PNS postganglionic
Synthesis of Ach by?
Choline acetyltranferase
RLS of transport Ach?
Choline acetyltranferase
Ach transported into vesicle for storage by?
VAT
Proteins important in release of Ach?
VAMPs, SNAPs
Blocked by?
Botox
Termination is carried out by?
AChE
Adrenergic transmission
45
Norepi = primary transmitter for?
SNS postganglionic
Exceptions that use Ach?
Sweat glands, skeletal muscle
Exceptions that use dopa?
Vasodilation of renal blood vessels
Synthesis of norepi by? 3
tyrosine hydroxylase, dopa decarboxylase, hydroxylase
RLS of norepi transport?
tyrosine hydroxylase
Inactivation in cytoplasm occurs by?
MAO
Vesicular transporter inh by?
reserpine
Termination is carried out by?
Diffusion & reuptake, esp by NET
Inactivation in synaptic cleft by?
MAO, COMT
Mnemonic for G-protein classes of R?
Qiss & qiq til ur siq of sqs (kiss and kick til ur sick of sex)
R it stands for?
a1, a2, b1, b2, M1, M2, M3, D1, D2, H1, H2, V1, V2
a1 fx? 4
vasoconstriction, mydriasis, incr intestinal sphincter tone, incr bladder sphincter tone
a2 fx? 2
dec symp outflow, dec insulin release
b1 fx? 3
incr HR, incr contractility, incr renin
b2 fx? 6
vasodilation, bronchodilation, incr HR, incr contractility, incr insulin release, dec uterine tone
M1 fx? 2
CNS, ENS
M2 fx? 2
Dec HR, Dec atrial contractility
M3 fx? 6
incr exocrine gland, incr peristalsis, bladder contraction, bronchoconstrition, miosis, accomodation
D1 fx? 1
relax renal SM
D2 fx? 1
modulate NT release, esp brain
H1 fx? 4
incr mucus production, bronchiolar contraction, pruritis, pain
H2 fx? 1
incr gastric acid
V1 fx? 1
SM contraction
V2 fx? 1
H2O perm & reabsorption in kidney collecting tubule
Cholinomimetics
57
Nicotinic toxicity: 2
CNS stim followed by depression, fasciculations and paralysis
2 classes that act as AChE-I
Carbamates, organophosphates
Which are direct cholinomimetics? 4
bethanechol, barbachol, pilocarpine, nicotine
Which is used for postop/neurogenic ileus or urinary retention
neostigmine, bethanechol
which is used for myasthenia gravis 3
neostigmine, edrophonium, pyridostigmine
which is used for glaucoma 3
physostigmine, carbachol, pilocarpine
which is used for Sjogren's syndrome
pilocarpine
what is the prototype for carbamate?
neostigmine
what is the prototype for organophosphate?
parathion
Cholinergic blockers
65
Prototype?
Atropine
Mnemonic for atropine tox? 6
hot as hare, dry as bone, red as beet, full as flask, blind as bat, mad as hatter
Which is used for Parkinsons? 2
benztropine, biperiden
Which is used for motion sickness?
Scopolamine
Which is used to produce mydriasis and cycloplegia? 3
atropine, cyclopentolate, tropicamide
Which is used to reduce asthma/COPD Sx? 2
ipratropium, tiotropium
Which is used to reduce transient hypermotility? 3
clycopyrrolate, dicyclomine, methscopolamine
What reduces urgency, spasm, incontinence? 3
oxybutynin, tolterodine, darifenacin
Sympathomimetic
73
Direct general agonists 1
epinephrine
indrect general agonists, releasers 3
amphetamine, ephedrine, tyramine
indirect general agonsists, uptake inh 2
Cocaine, TCA
Selective for a1, a2, b1
norepinephrine
selective a1 > a2 2
midodrine, phenylephrine
selective a2 > a1 2
clonidine, oxymetazoline
selective for b1 = b2 1
isoproterenol
selective for b1 > b2 1
dobutamine
selective for b2 > b1 3
albuterol, metaproterenol, terbutaline
dopa agonists 2
dopamine, bromocriptine
which is used for ADHD? 2
amphetamine, methylphenidate
which is used for anaphylaxis? 1
epinephrine
which is used for asthma? 5
epi, isoproterenol, albuterol, metaproterenol, terbutaline
which is used for decongestion? 2
phenylephrine, oxymetazoline
which is used for glaucoma? 1
epi
which is used for narcolepsy? 2
amphetamine, methylphenidate
which is used for neurogenic hypotension? 1
ephedrine
which is used for obesity? 2
amphetamine, methylphenidate
which is used for shock, HF? 2
dopamine, dobutamine
which is used for urinary incontinence? 1
ephedrine
which is used to cause mydriasis? 1
phenylephrine
which is used to cause vasoconstriction? 3
epi, phenylephrine, cocaine
Adrenoreceptor blockers
83
nonselective alpha-blockers? 2
phentolamine, phenoxybenzamine
a1 selective 3
prazosin, terazosin, doxazosin
a2 selective 1
yohimbine
nonselective beta-blocker 5
propanolol, carvedilol, labetalol, nadolol, timolol
b1 selective 3
metoprolol, atenolol, esmolol
which is used for mastocytosis?
phenoxybenzamine
which is occasionally used for carcinoid tumor?
phenoxybenzamine
which is used for ED by direct injection? 2
phentolamine, yohimbine
which is used for HTN? 7
prazosin, doxazosin, terazosin, atenolol, propanolol, metoprolol, timolol
which is used for urinary retention? 4
prazosin, doxazosin, terazosin, tamsulosin
which is used for angina pectoris? 2
propanolol, metaprolol
which is used for arrythmia prophylaxis after MI? 3
propanolol, metaprolol, timolol
which is used for SVT? 3
propanolol, esmolol, acebutolol
which is used for HF? 3
carvedilol, labetalol, metoprolol
which is used for HCM? 1
propanolol
which is used for migraine prophylaxis? 1
propanolol
which is used for tremors? 1
propanolol
which is used for thyroid storm? 2
propanolol, esmolol
which is used for glaucoma? 1
timolol