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14 Cards in this Set
- Front
- Back
Bicalutamide
Nilutamide Flutamide MOA |
block androgen rec.
-always give w/ GnRH analog to prevent (+) testosterone |
|
effects blood
Bicalutamide |
(+) testosterone and LH
-give w/ GnRH analog to prevent |
|
prefer Bicalutamide for androgen rec. block
|
-less hepatic toxicity
-taken 1qd |
|
Spirinolactone MOA
|
aldosterone rec. antagonist
(-) testosterone synthesis (+) partial estrogen and progesterone rec. treat hirsituism in females |
|
GnRH rec. agonists
|
Lupron (depot i.m.)
Gosrelin acetate (implant 3mo.) Nafarelin acetate (intranasal bid) Gonadorelin- i.v. or s.c. |
|
GnRH effects
|
-initial (+) testosterone, LH, FSH
-continuous = (-) due to GnRH rec. non-pulsatile |
|
GnRH analog uses
|
-prostatic carcinoma
-precocious puberty -endometriosis/ fibroid tumors |
|
Cetrolix
Degarlix |
GnRH antagonists
Tx: advanced prostatic cancer |
|
a1-rec. antagonists
|
-terazoin
-doxazoin -tamsulosin |
|
a1-rec. antagonists MOA
|
-terazoin/ tansulodin/ doxazoin
reversible relaxation of sm muscle decrease R to flow |
|
Tx HTN and BPH
|
terazoin (T50= 12h)
doxazoin (T50= 22h) |
|
Tamsulosin
|
a1-rec. antagonist
-better to avoid orthostatic hypotension and dizziness -worse for impotence |
|
5a-reductase (-)
|
finisteride
dutasteride prevent conversion of testosterone to 5-DHT |
|
Finasteride
|
(-) both types of 5a-reductase
plasma LH no change |