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71 Cards in this Set
- Front
- Back
Epinephrine
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α1α2β1β2D1 agonist – does not penetrate BBB
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Norepinephrine
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α1α2β2 agonist – not used clinically
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Entacapone
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Inhibits peripheral COMT – prevents Parkinson tx “wearing off”
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Phenelzine
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Inhibits MAO; treats parkinson’s and severe depression
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Ephedrine
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α1β1 agonist indirectly; direct β2 agonist; CNS stimulation, long duration
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Pseudoephedrine
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α1β1 agonist; indirect only; CNS stimulation
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Phenylpropanolamine
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β1 agonist; Dietary aid, increases risk of stroke
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Amphetamines
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Releases NE, blocks reuptake; tx ADD and narcolepsy
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Methamphetamines
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Increased SNS; No clinical use; irritability, hallucinations; memory loss; permanent loss of DA and 5HT neurons
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Cocaine
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Blocks reuptake of DA in CNS/NE in PNS; used as local anesthetic and for vasoconstriction, fast acting
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Tyramine
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Competes w/ Dopamine; not used clinically, found in foods. Releases NE, MAO converts it to inactive products
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Reserpine
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Blocks NE release; used for CNS tranquilization and HTN; causes depression, suicide, increased GI tone, nasal stuffiness, weight gain
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Methyldopa
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Interferes with NE release; HTN; causes sedation, dry mouth; competes with dopamine for transport into vesicles to function as false transmitter
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α-methyltyrosine
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Inhibits NE synthesis
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α-methyldopa hydrazine
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Inhibits L-DOPA synthesis in the periphery; used with L-DOPA in treatment of parkinson’s
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Phenylephrine
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α1 agonist – reduces IOP
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Clonidine
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α2 agonist – CNS opiate withdrawal
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α-methyl NE
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α2 agonist - hypertension
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Phentolamine
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α1α2 antagonist – not used clinically - reversible
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Phenoxybenzamine
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α1α2 antagonist – not used clinically - irreversible
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Prazosin
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short acting α1 antagonist; tx HTN w/o tachycardia; causes dizziness
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Terazosin
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longer acting α1 antagonist; tx HTN w/o tachycardia; causes dizziness
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Tamsulosin
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α1a antagonist; treats BPH
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Isoproterenol
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β1 β2 agonist; very powerful
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Dopamine
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β1—some α1β2D1 agonist; cardiac stimulant; short acting; less likely to cause dysrhythmia
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Dobutamine
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β1 agonist—some α1β2 agonist
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Albuterol
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β2 agonist; tx tachycardia, tremor, hyperglycemia, hypokalemia
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Terbutaline
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β2 agonist; tx tachycardia, tremor, hyperglycemia, hypokalemia
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Salmeterol
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β2 agonist; tx tachycardia, tremor, hyperglycemia, hypokalemia
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Ritodrine
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β2 agonist
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Propranolol
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β1 β2 antagonist; can cause heart failure in diseased hearts; can cause bronchoconstriction in asthmatics
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Nadolol
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β1 β2 antagonist; trx HTN, long halflife, no CNS effects
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Timolol
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β1 β2 antagonist; trx Glaucoma and high IOP
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Pindolol
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β1 antagonist; HTN
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Labetalol
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β1 β2 and α1 antagonist; HTN
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Carvedilol
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β1 β2 and α1 antagonist; Post-MI
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Metoprolol
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β1, some β2 antagonist; HTN and angina
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Atenolol
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β1 antagonist; HTN and angina; longer acting, no CNS effect
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Esmolol
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β1 antagonist; Cardiac dysrhythmias; short acting
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Acetylcholine
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M and N agonist; not used clinically
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Carbachol
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M and N agonist – glaucoma, counteract atropine
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Bethanechol
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Mus agonist; tx urinary retention
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Pilocarpine
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Mus agonist; tx glaucoma
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Methacholine
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Mus agonist; dx of bronchial asthma
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Succinylcholine
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Nic agonist
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Edrophonium
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ChE Inhibitor Myasthenia Gravis
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Neostigmine
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ChE Inhibitor MG
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Physostigmine
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ChE Inhibitor Glaucoma
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Pyridostigmine
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ChE Inhibitor MG, long acting
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Malathion
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ChE Inhibitor Irr - pesticide
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Parathion
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ChE Inhibitor Irr - pesticide
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Echothiophate
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ChE Inhibitor Irr - Glaucoma
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Tacrine
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ChE Inhibitor Alz
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Donepezil
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ChE Inhibitor Alz
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Rivastigmine
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ChE Inhibitor Alz
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Atropine
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Mus antagonist; tx incontinence; CNS stimulator
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Scopolamine
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Mus antagonist; tx seasickness, vomiting, nausea
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Cyclopentolate
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Mus antagonist; shortacting mydriasis
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Tropicamide
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Mus antagonist, shortacting mydriasis
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Ipratropium bromide
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Mus antagonist; treats asthma by shutting down vagus
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Curare
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Nic antagonist Surgical anesthesia; no CNS
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Mivacurium
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Nic antagonist Settling fractures, short acting
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Trimethaphan
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Nic antagonist Controlled hypotension
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Pilocarpine + Carbachol
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Mus agonist
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Physostigmine + Echothiophate
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Mus agonist – increased outflow
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Timolol
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β2 (and beta1) antagonist – decreased humor production
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Epinephrine + Dipivefrin
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α1 α2 agonist – vasoconstriction, reduced production of aqueous humor
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Diazepam
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+GABA; sedation
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Benzodiazepines
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+GABA; sedation
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Baclofen
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+GABA; less sedative
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Dantrolene
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Blocks Ca release
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