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46 Cards in this Set
- Front
- Back
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NO MOA
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Ø NMDA
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NO
+ |
low lambda
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NO
- |
no surg anesthesia, only adjuvant
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HALOthane MOA
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↑ GABA binding
↑ Cl influx |
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HALOthane +
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non-irritating
mm relax |
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HALOthane -
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high lambda
Ø analgesia ASE-hypotn, tachyARR, HEPATOX, malig hypRtherm |
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ENflurane MOA
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↑GABA ↑Cl
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ENflurane +
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mod. analg
mm relax |
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ENflurane -
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↓CO
↑seizures, C/I for pt with siezure d/o |
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ISOflurane MOA
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↑GABA,
↑ Cl |
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ISOflurane +
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mod sk mm relax
no effect on CO,↑ coronary BF, ↓ myocardial O2 demand Prefered for neurosx |
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ISOflurane -
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bad smell
bronchoirritates- coughing, spasms |
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DESflurane MOA
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↑ GABA, ↑Cl
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DESflurane +
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lowest lambda--OP sx
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DESflurane -
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bronchospasm, have to use IV anesthetic for induction then use DESflurane for mantainence
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SEVOflurane MOA
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↑GABA ↑Cl
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SEVOflurane +
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low lamda
mm relax Bronchodilator pleasant odor |
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SEVOflurane -
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possible kidney tox via Compound A
possibly ↑ siezures |
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ultra short BARB MOA
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↑GABA, ↑Cl
prolong Cl channel openign |
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ultra short BARB +
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lipid sol
fast induct |
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ultra short BARB -
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hyperalgesia-if alone-tachyC, diaphoresis
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THIOPENTAL
methohexital, shorter t1/2 |
prolong Cl channel
opening |
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THIOPENTAL
methohexital, shorter t1/2 + |
10-30s induct
↓ ICP, used for induction and mantainence for short proced |
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Ketamine
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anesth- ØNMDA
analg- opiod |
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Ketamine +
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bronchodilator
No need for intubation as respiration is spontaneous |
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Ketamine -
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dysphoria(PCP related)
dilates cerebral vasc. ↑ICP ↑CO and BP, caution in cardiac pt, but useful for shock pt -recovery- PCP dysphoric halluc, etc admin BZ prior to ketamine can prevent these |
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Etomidate MOA
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ultra short acting
NON barb hypnotique |
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Etomidate +
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INDUCTION
miminal CV/ Resp, ideal for CV dz pt |
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Etomidate -
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post-op N/V
not rec. for maintenance or in critcally ill pt |
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PROPOFOL MOA
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Unknown
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PROPOFOL +
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rapid recovery
antiemetic-no postop N/V |
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PROPOFOL -
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mild hypotn, mild neg INOtropic
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ADJUNCTS TO GENERAL ANESTHESIA
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--
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BZs MOA
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↑GABA, ↑Cl channel frequency
(end in lam or pam) |
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MIDazolam
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short acting
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DIAzepam
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long acting
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LORazepam
|
intermed acting
pre op anxiolytic |
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TRIazolam
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PO only
pre op anxiolytic amnesia |
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FLUMAZENIL
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BZ blocker to reverse post-op sedation
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OPIOIDS MOA, ending, SE
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usu MU receptor
(usually end in TANIL, except morphine & demerol) SE: resp. depr, ↑ ICP |
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SUFENtanil
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MOST POTENT
used for pre, during, post-op analgesia |
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AFENtanil
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shorter 1/2 life
used for pre, during, post-op analgesia |
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REMIFENtanil
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t ½ = 10-15 min
analgesia during anesthesia |
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FENTanyl
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80-100 x potent than morphine
NO HISTAMINE release quick onset, short duration |
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MEPERidine
(Demerol) |
shorter act than morphine
vagolytic- ↓ secretions C/I w2 week/in 2wk s of MAOI-- serotonin syndrome |
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Morphine
|
histamine release
supresses cough reflex ↓cough-choke on ↑secretions vasodilation – reflex TachC |
