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25 Cards in this Set
- Front
- Back
Prostaglandins role 3 things |
1. turn off cAMP pathway to turn off proton pump 2. turn on EP3 for mucous and bicarbonate (cytoprotective) 3. Vasodilation to flush out toxins |
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Somatostatin analog drug is |
Octreotide |
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effects of octreotide |
decrease gastrin release, decrease gastric motility. For Zollinger Ellison syndrome and severe diarrhea. for supressing growth hormone and for actromegaly. |
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Pirenzepine MOA |
M1 selective antagonist used in other countries. In US we use hyoscamine. |
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Cimetidine MOA |
H2 blocker decreasese both basal and H ion secretion |
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H2 blockers are best for |
nocturnal dyspepsia |
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H2 blockers side effects with cimetidine |
effeccts of CYP 3a4, 2d6, 1a2 and aldehyde oxidase. Anti androgenic effects like gynecomastia. CONFUSION and CNS HA, fatigue. Needs dosing adjustments if bad kidneys. |
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Omeprazole inhibits what enzymes |
2C19, 3A4 |
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omeprazole SE's |
diarrhea,nasuea, HA, rash |
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Omeprazole affects absorption of what drugs |
antifungals because they like acidic environment. Clopidogrel |
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Omeprazole used chronically may decrease the |
absorption of iron calcium magnesium. |
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Onset of omeprazole |
full efficacy delayed 3-4 days. give 30 to 60 min before food. Not with food. due to 1/2 bioavail. |
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Risks with PPI and H2's |
-Reflex increased gastrin -Increased infections of C Diff with long term use Pneumonia with short term use, not long term. |
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Risk with PPI only, and how many days not to exceed |
Hip fracture; 60 days. |
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Misoprostol MOA |
Prostaglandin pg 1 analog. Action to inhibit cAMP dependent pump activation, increase secretion of mucous and bicarbonate. |
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Misoprostol indication |
NSAID induced dyspepsia or ulceration |
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Misoprostol SE's |
significant diarrhea and abdominal cramping |
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How sucralfate works |
When in presence of pH less than 4, turns into a gel. Will bind to exposed tissues and forms a protective barrier. But doesn't stay long. So need to QID. |
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sucralfate is ideal for treating |
duodenal ulcers |
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Sucralfate main SE: |
constipation |
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If renally compromised, sucralfate can cause |
Aluminum toxicity. |
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Bismuth how it works |
reacts with exposed tissue and creates a barrier and ALSO increase proudction of mucous and bicarbonate. ALSO antibacterial action. |
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Bismuth SE's |
black hairy tongue. Dark stools. Bismuth toxicity with renally impaired. |
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Primary contributor to peptic ulcer disease |
H Pylori |
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H Pylori is a bacterium.. |
gram negative athat produce enzymes and bicarbonate that protects it from environment. The inflammatory response is what makes for gastric ulcerations. Some people generate greater inflammatory. |