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32 Cards in this Set
- Front
- Back
True or False: dietary iron absorption is highly regulated
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True
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What is the average absorption of iron in an adult?
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1mg/day
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What is the rate of absorption of iron in women between puberty and menopause?
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2mg/day
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What increases iron absorption? Hint: there are 5
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heme iron
ethanol comsumption excessive consumption of ascrobic acid cigarette smoking hemochromatosis |
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Are sweat, tears, and sloughing of intestinal mucosa a major or minor route of iron elimination?
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minor
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What are the potential routes of iron elimination in women between puberty and menopause?
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menstruation
fetal growth lactation |
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True or False: ingestion of oral contraceptives do not reduce excretion of iron?
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Fals: oral contraceptives do reduce iron excretion via menstrual blood
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This enterocyte transports iron from the lumen through apical membrane
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DMT-1 (divalent metal transporter)
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This enterocyte mediates rion efflux through basal membrane
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Ferroportin
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What regulates ferroportin expression?
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Hepsidin
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True or False: dietary iron absorption is highly regulated
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True
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What is the average absorption of iron in an adult?
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1mg/day
|
|
What is the rate of absorption of iron in women between puberty and menopause?
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2mg/day
|
|
What increases iron absorption? Hint: there are 5
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heme iron
ethanol comsumption excessive consumption of ascrobic acid cigarette smoking hemochromatosis |
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Are sweat, tears, and sloughing of intestinal mucosa a major or minor route of iron elimination?
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minor
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This protein transports iron in the blood
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tranferrin
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How many extracellular domains do the transferrin receptor have?
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2
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What state does transferrin have to be in to be able to bind iron?
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monoferric or diferric state
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What protein stores iron?
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ferritin
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What part of ferritin incorporates iron into the core?
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heavy chain
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What part of ferritin chelates core iron?
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light chain
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Above what level does ferritin lose its efficiency to store iron?
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1200-1400 iron atoms
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how much iron atom can ferritin store?
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4200 iron atoms
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what iron storing protein is found in the exocrine gland and is excreted durig sweating, crying, lactation, pregnancy, and menstruation?
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lactoferrin
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In what state does IRP1 have aconitase activity?
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4Fe-4S state
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In what state does IRP1 bind to IRE?
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3Fe-4S state
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In what state does IRP2 have aconitase activity?
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IRP2 does not have aconitase activity period
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When IRP is bound to IRE, is ferritin made?
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no
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When IRP is bound to IRE, is transferrin made?
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yes
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When IRP is unbound to IRE, is ferritin made?
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yes
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When IRP is unbound to IRE, is transferrin made?
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no
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In malignant cells, is transferrin or ferritin increased?
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transferrin
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