Phar 641 Histamine, Serotonin, Ergot Alkaloids

Front 1

What am I:
biological factors which act like hormones, have a brief duration, act near the site of synthesis, and are not blood borne

Back 1

autacoids

Front 2

Histamine and serotonin fall under what class of autacoids?

Back 2

amine autacoids

Front 3

prostaglandins, thromboxanes, and leukotriens fall under what class of autacoids?

Back 3

eicosanoids

Front 4

kinins, renin, and angiotensins fall under what class of autacoids?

Back 4

peptide autacoids

Front 5

What am I:
bio-amine derived from the decarboxylation of aminoacid histidine

Back 5

histamine

Front 6

This type of histamine receptor is located on smooth muscle, endothelium, and sensory nerves

Back 6

H1

Front 7

This type of histamine receptor causes:
bronchoconstriction by smooth muscle contraction
vasodilation by nitric oxide release
pain and itching via neuronal stimulation

Back 7

H1

Front 8

This type of histamine receptor is located on the gastric mucosa

Back 8

H2

Front 9

What generation antihistamine am I:
small, lipophilic molecules that can cross the BBB
not highly selective to histamine receptors - also blocks cholinergic, adrenergic, and serotonin receptors

Back 9

first generation

Front 10

sedation, dry mouth, urinary retention, and tachcardia are adverse effects of 1st generation antihistamines due to which receptor blockade?

Back 10

cholinergic

Front 11

postural hypotension is an adverse effect of first generation antihistamine due to what receptor blockade?

Back 11

adregergic

Front 12

increased appetite is an adverse effect of first generation antihistamine due t owhat receptor blockade?

Back 12

serotonin

Front 13

Which antihistamines have marked sedation?

Back 13

dimenhydrinate
diphenhydramine
hydroxyzine
promethazine

Front 14

Which antihistamines are also used for motion sickness?

Back 14

cyclizine
meclizine
dimenhydrinate
diphenhydramine

Front 15

What are the clincal uses of first generation antihistamines?

Back 15

symptomatic relief of seasonal allergic rhinitis and urticaria where histamine is the primary mediator

Front 16

Which antihistamine also has antiemetic activity?

Back 16

promethazine

Front 17

what generation antihistamine am I:
Does not readily cross BBB
more selective for H1 receptors

Back 17

second generation

Front 18

These drugs are metabolite derivatives or active enantiomers of existing drugs. They are safer, faster acting, and/or more potent than 2nd generation antihistamines

Back 18

fexofenadine
desloratadine
levoceterizine

Front 19

What receptor am I:
monoamine neurotransmitter synthesized from the amino acid tryptophan

Back 19

serotonin

Front 20

Drugs that end in ______ are selective serotonin agonist.

Back 20

triptan

Front 21

What are selective serotonin agonists indicated for?

Back 21

abortive therapy in the treatment of migraine and cluster headaches

Front 22

What class of drug am I:
selective agonist for serotonin in the cranial arteries.
cause vasoconstriction and reduce release of pro-inflammatory neuropeptides

Back 22

selective serotonin agonist

Front 23

concurrent use of triptans with these drugs can predispose patients to serotonin syndrome

Back 23

MAOI
SSRI
SNRA

Front 24

What is contraindicated in triptans?

Back 24

patients with CAD

Front 25

What is the common adverse effect of triptans

Back 25

paresthesia

Front 26

ergotamine and dihydroergotamine have this selectivity

Back 26

vasoselectivity

Front 27

ergonovine has this selectivity

Back 27

uteroselectivity

Front 28

lysergic acid and diethyamide has this selectivity

Back 28

CNS selectivity

Front 29

which serotonin receptors are triptans selective for?

Back 29

5HT-1B
5HT-1D

Front 30

Which serotonin receptors are ergotamine and dihydroergotamine selective for?

Back 30

5HT-1A
5HT-1D

Front 31

Which serotonin receptor is ergonovine selective for?

Back 31

5HT-1A
5HT-1D

Front 32

Which receptor are lysergic acid and diethyamide selective for?

Back 32

DA
5HT-2

Front 33

What substance facilitates the oral bioavailability of ergotamine?

Back 33

caffeine

Front 34

What drug am I:
semisynthetic ergot alkaloid derivative
dopamine agonist
activates postsynaptic dopamine recetpros in tuberinfundibular and nigrostriatal pathways

Back 34

bromocriptine

Front 35

What is bromocriptine indicated for?

Back 35

hyperprolactinemia associated with amenorrhea with or without galactorrhea, infertilibity or hypogonadism
prolactin-secreting adenomas
acromegaly
parkinson's disease