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7 Cards in this Set
- Front
- Back
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rationale for using folate + B12 + B6 |
homocysteinuria the "homocystein hypothesis" -high plasma HCY associated w graded increase risk of MI, angina, CAD, stroke, PVD, ISH, carotid occlusion, mortality, depression -folic acid, B12, B6 said to lower homocysteine |
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evidence for folate + B12 + B6 |
there is no benefit (even post-MI) may do more harm than good |
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rationale for using vitamin E |
inhibition of LDL oxidation epidemiologic studies -high vit E intake associated w lower CV disease risk expected effect size small to moderate (10-50% CV risk reduction) -RCTs required |
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evidence for Vit E |
not useful (there is evidence that it does not prevent CVD) vit E increases risk of hemorrhagic stroke (it is not neutral, it can cause harm) |
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evidence for calcium |
supplementing with calcium (solely) seems to cause MI the risks greatly outweigh the benefits in an elderly popn -calcium supplementation as monotherapy in elderly people not justified -reasonable to continue supplementation in people taking bisphosphonates |
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evidence for vit D |
correlation between vit D and heart benefits -does not mean causation giving Vit D does not benefit CV disease do not recommend prescribing vit D supplementation beyond recommended daily needs for purpose of preventing CVD or death or improving QoL |
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evidence for multivitamin |
bad association between all components of multivitamin and mortality (iron, zinc, etc) vit supplementation has no effect on CV health possible overall reduction in incidence of cancer |
