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12 Cards in this Set
- Front
- Back
5 factors affecting the dose-response relationship of a toxin
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1. route
2. biotransformation 3. health/nutritional status 4. age 5. genetics |
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Basic mechanism of chemical carcinogenesis
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--bind DNA
--misreading when making daughter cells --mutations passed down |
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Describe category A teratogens
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no teratogenicity in animals & humans
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Describe category B teratogens
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Either:
1. no teratogenicity in animals, no data for humans 2. teratogenicity in animals, non-teratogenic in humans |
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Describe category C teratogens
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either:
1. teratogenic in animals, no human data 2. no data for animals or humans *give when benefit justifies risk |
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Describe category D teratogens
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human risk present, benefits to mom may be acceptable in life-threatening/serious ds
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Describe category X teratogens
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risk clearly outweighs possible benefit
contraindicated in preg women/those who might become preg |
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Ach-ase (cholinergic) syndromes:
1. Common cause 2. 5 Muscarinic sxs 3. 3 Nicotinic sxs 4. 2 CNS sxs |
1. insecticides inhibit Ach-ase (organophosphate/carbamate)
2. sweating, miosis/blurred vision, wheezing, GI cramps/diarrhea, bradycardia/hypoTN 3. fasiculations/cramps, weakness/paralysis, respiratory compromise 4. anxiety, seizures |
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Anticholinergic syndrome:
1. 5 causative agents 2. 5 Peripheral effects 3. 3 Central effects |
1. atropin, scopolamine, TCADs, antihistamines, jimson weeds
2. dry mouth, tachycardia, dry skin, flushing, dilated pupils 3. lethargy, seizures, confusion |
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List 2 Hb-opathies and their causes
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1. carboxyhemoglobinemia from CO
2. methemoglobinemia from sulfonamides |
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triad of narcotic overdose
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1. pinpoint pupils
2. respiratory depression 3. hypoTN |
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4 methods of removal of toxin from GI tract
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1. vomiting
2. gastric lavage 3. activated charcoal 4. whole bowel irrigation |