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13 Cards in this Set
- Front
- Back
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Hemicholinium, Triethylcholine |
Inhibitors of ACh synthesis. Pre-junctional acting agent (Inhibit transmission). |
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Vesamicol |
inhibitor of ACh storage. Pre-junctional acting agent (Inhibits transmission). |
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Botulinum toxin |
(lethal dose: 1 μg/kg) produced by Clostridium botulinum. Inhibits the binding of Ach vesicles with the cell membrane. Pre-junctional acting agent (Inhibits transmission). Acts for several months.Given into the muscle in cosmetic surgery, blepharospasm, strabism, spasticity. Also used in hyperhidrosis and overactive bladder. (Aminoglycosides and Mg++ions have the same effect) |
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D-tubocurarine |
active molecule of curare toxin. Non-depolarizing blocking agent (muscle relaxant) – long duration of action. So it’s a reversible NM-ACh receptor antagonist. Benzyl isochinoline compound. Eliminated by kidneys and liver. It’s side effects make it unfit for clinical use. |
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Doxacurium |
long duration of action, non-depolarising NMJ blocker (Nm-Ach receptors). Eliminated by the kidneys. Benzyl isochinoline compound. |
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Atracurium |
Non-depolarizing blocking agent (Reversible Nm-Ach receptors antagonist) – Intermediate DoA. Benzyl isochinoline compound. Causes unwanted histamine release and siezures. Not used clinically. |
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Cisatracurium |
Replaced atracurium clinically. Is a stereoisomer |
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Mivacurium |
Non-depolarizing blocking agent (Reversible Nm-Ach receptors antagonist) – Short DoA. Benzyl isochinoline compound. Causes some unwanted histamine release. Not preferred clinically |
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Vecuronium, Rocuronium |
Non-depolarizing blocking agent (Reversible Nm-Ach receptors antagonist). Ammonio-steroidal compound. Intermediate duration of action. |
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Sugammadex Sugondese nuuuuts |
binds steroidal relaxants (Vecuronium and Rocuronium) in the plasma, inhibiting the effect of non-depolarizing muscle relaxants by chemical antagonism. Used for decurarization. |
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The only depolarising blocking agent? |
Suxamethonium (= succinylcholine) Nicotinic R agonist. It keeps the inotropic receptor open, leading Phase I and Phase II blocks. Short DoA (5-10m).*Can cause malignant hyperthermia! (treated with: dantrolene, NaHCO3, physical cooling) |
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What else can block release of Ach from presynaptic neuron expect Botulinum Toxin? |
Aminoglycosides and Mg2+ |
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What is the side effect of the non-depolarising muscle relaxants? |
Ganglion-blocking effects |
