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5 Cards in this Set
- Front
- Back
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What are the functions of the pentose phosphate pathway?
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-produce NADPH to protect against oxidative damage
-produce NADPH for reductive biosynthesis -produce ribose 5-phosphate for RNA, DNA, and coenzyme factor synthesis; can also be recycled to make 6-C sugars |
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What is the first molecule that is reacted upon in the pentose phosphate pathway? What other pathway can this molecule undergo?
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-glucose 6-phosphate
-glycolysis |
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What regulates the pentose phosphate pathway, i.e. what determines whether or not glucose 6-phosphate will go through glycolysis or the pentose phosphate pathway?
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-high [NADPH], glucose 6-phosphate will go through glycolysis (PPP will make more NADPH)
-low [NADPH], glucose 6-phosphate will go through PPP (b/c need to make more NADPH) -Basically, when the cell needs more NADPH, it will undergo PPP |
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How does NADPH protect against oxidative damage?
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-NADPH reduces glutathione (to GSH) via glutathione reductase
-GSH has SH that can reduce free radicals -glutathione peroxidase will oxidize glutathione (GSH to GSSG) |
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Glutathione is a tripeptide molecule. What are the 3 peptides of glutathione?
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-cysteine
-glutamate -glycine |
